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STAT3-IN-39 (compound 10K) 是一种具有口服活性的STAT3抑制剂,能有效抑制STAT3磷酸化,在NIH-3T3细胞中的IC50值为0.47 μM。它能够抑制TGF-β1诱导的纤维化反应,并阻止A549细胞的上皮-间质转化。STAT3-IN-39 可用于研究特发性肺纤维化。
STAT3-IN-39 (compound 10K) 是一种具有口服活性的STAT3抑制剂,能有效抑制STAT3磷酸化,在NIH-3T3细胞中的IC50值为0.47 μM。它能够抑制TGF-β1诱导的纤维化反应,并阻止A549细胞的上皮-间质转化。STAT3-IN-39 可用于研究特发性肺纤维化。
产品描述 | STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis. |
分子量 | 422.42 |
分子式 | C20H17F3N2O3S |
CAS No. | 3037596-35-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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