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CCR2 antagonist 4 hydrochloride
还可以产品编号 T19230Cas号 1313730-14-1
别名 Teijin compound 1 hydrochloride
CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).
CCR2 antagonist 4 hydrochloride
还可以产品编号 T19230 别名 Teijin compound 1 hydrochlorideCas号 1313730-14-1
CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 542 | 5日内发货 | |
| 5 mg | ¥ 913 | 5日内发货 | |
| 25 mg | ¥ 4,150 | 1-2周 | |
| 50 mg | ¥ 5,400 | 1-2周 | |
| 100 mg | ¥ 8,320 | 1-2周 | |
| 1 mL x 10 mM (in DMSO) | ¥ 1,130 | 5日内发货 |
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生物活性
化学信息
| 产品描述 | CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM). |
| 靶点活性 | CCR2b:180 nM |
| 体外活性 | Ile263 and Thr292 in CCR2 contribute significantly to the binding of CCR2 antagonist 4 in CCR2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride. Residue Glu291 in TM7 contributes substantially to the binding of the protonated CCR2 antagonist 4 hydrochloride, and CCL2 [2]. |
| 体内活性 | In ApoE-deficient mice, CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta [3]. |
| 别名 | Teijin compound 1 hydrochloride |
| 分子量 | 476.32 |
| 分子式 | C21H22Cl2F3N3O2 |
| CAS No. | 1313730-14-1 |
| 密度 | no data available |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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