6,7,4'-Trihydroxyflavanone possesses various pharmacological activities, including anti-rheumatic, anti-ischemic, anti-inflammatory, anti-osteoclastogenic, and protective effects against METH-induced deactivation of T cells. 6,7,4'-Trihydroxyflavanone can be used for studies about the treatment of METH-addicts suffering from neurodegenerative diseases.

6,7,4'-Trihydroxyflavanone（40 μM）未引起细胞毒性，但通过调节凋亡相关蛋白的表达、METH引起的氧化应激，以及在METH暴露的SH-SY5y细胞中的PI3K/Akt/mTOR磷酸化作用，减轻了METH引起的神经毒性。6,7,4'-Trihydroxyflavanone诱导了Nrf2的核内转移和HO-1的表达。6,7,4'-Trihydroxyflavanone对HO-1的诱导，减轻了METH引起的神经毒性[1]。

6,7,4'-Trihydroxyflavanone（20及50 mg/kg；口服）通过调节T细胞和结肠细胞的活性，减轻了由dextran sulfate sodium (DSS)引起的结肠炎症状，包括减轻体重、结肠缩短，以及结肠和肠系膜淋巴结中促炎性细胞因子表达的增强[2]。