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CB-1158 dihydrochloride (2095732-06-0 free base)

CB-1158 dihydrochloride is an effective and orally active inhibitor of arginase (IC50s: 86 nM and 296 nM for recombinant human arginase 1 and 2).

产品编号 T10692

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CB-1158 dihydrochloride (2095732-06-0 free base)

产品编号 T10692别名 INCB01158 dihydrochloride, CB-1158 dihydrochloride

CB-1158 dihydrochloride is an effective and orally active inhibitor of arginase (IC50s: 86 nM and 296 nM for recombinant human arginase 1 and 2).

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

规格	价格	库存
5 mg	¥ 2,075	期货
10 mg	¥ 3,605	期货
25 mg	¥ 7,005	期货

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产品介绍

生物活性

产品描述	CB-1158 dihydrochloride is an effective and orally active inhibitor of arginase (IC50s: 86 nM and 296 nM for recombinant human arginase 1 and 2).
靶点活性	Arginases II:296 nM , Arginases I:86 nM
体外活性	CB-1158 inhibits native arginase 1 (Arg1) in human granulocyte, erythrocyte, and hepatocyte lysate (IC50s: 178 nM, 116 nM, and 158 nM), and blocks Arg1 in cancer patient plasma (IC50: 122 nM). CB-1158 also exhibits potent inhibitory activity against arginase in human HepG2, K562 cell lines, and primary human hepatocytes (IC50s: 32, 139, 210 μM). CB-1158 shows no effect on NOS and not directly cytotoxic to murine cancer cell lines.
体内活性	CB-1158 (100 mg/kg, p.o., twice per day) decreases the number of myeloid cells and increases tumor-infiltrating cytotoxic cells in mice. CB-1158 in combination with LY 188011 inhibits tumor growth in mice bearing CT26 cancer cells.
别名	INCB01158 dihydrochloride, CB-1158 dihydrochloride

化学信息

分子量	360.04
分子式	C₁₁H₂₄BCl₂N₃O₅
CAS No.

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 50 mg/mL (138.87 mM)

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7775 mL	13.8873 mL	27.7747 mL	138.8735 mL
5 mM	0.5555 mL	2.7775 mL	5.5549 mL	27.7747 mL
10 mM	0.2777 mL	1.3887 mL	2.7775 mL	13.8873 mL
20 mM	0.1389 mL	0.6944 mL	1.3887 mL	6.9437 mL
50 mM	0.0555 mL	0.2777 mL	0.5555 mL	2.7775 mL
100 mM	0.0278 mL	0.1389 mL	0.2777 mL	1.3887 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLddH2O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

CB 1158 dihydrochloride (2095732 06 0 free base)CB 1158INCB01158 DihydrochlorideCB-1158CB1158INCB-011582095732-06-0 free baseINCB 01158 DihydrochlorideINCB 01158CB 1158 DihydrochlorideCB1158 DihydrochlorideINCB-01158 DihydrochlorideCB-1158 Dihydrochloride2095732-06-0CB1158 dihydrochloride (2095732060 free base)INCB01158

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