AP 811 acetate is a selective antagonist of the atrial natriuretic peptide clearance receptor (ANP-CR, NPR3), demonstrating high affinity with a K_i value of 0.48 nM and exhibiting over 20,000-fold selectivity for NPR3 compared to NPR1. It effectively inhibits ANP-induced pump stimulation [1] [2].

在心肌细胞增殖过程中，AP 811 acetate（浓度范围10-500 nM）能够完全抑制低浓度ANP（10 nM）诱导的心肌细胞增殖增强效应[3]。