4
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11490 |
GSK2945
|
Others | Others |
GSK2945 is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism. | |||
T11490L |
GSK2945 hydrochloride (1438071-12-5 free base)
GSK2945 hydrochloride |
Others | Others |
GSK2945 hydrochloride is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism. | |||
T62852 |
GSK2945 hydrochloride
|
Others | Others |
GSK2945 hydrochloride 是一种叔胺,是一种高特异性的 Rev-erbα/REV-ERBα(小鼠/人反向成红细胞病病毒α) 拮抗剂,他们的 EC50 值分别为 21.5 μM 和 20.8 μM。GSK2945 hydrochloride 能够提高胆固醇 7α-羟化酶 (CYP7A1) 水平和胆固醇代谢。 | |||
T84963 |
5α-Androstan-3β-ol
NSC 50887 |
Others | Others |
5α-Androstan-3β-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 µM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 µM. It selectively inhibits the hydroxylase activities of 16α- and 6β-hydroxylase over 16β- or 7α-hydroxylase, with IC50 values of 70 and 110 µM, compared to >150 µM for the latter enzymes, indicating a specificity in its enzyme inhibition profil... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8153 |
glycohyodeoxycholic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Glycohyodeoxycholic acid 是一种人体次级胆汁酸猪去氧胆酸的主要代谢物,能够预防胆结石的形成。 |