Exicorilant

Name: Exicorilant
Brand: TargetMol
SKU: T15264
Rating: 4.5 (1 reviews)

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产品编号 T15264Cas号 1781244-77-6

别名 CORT 125281

Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.

Exicorilant

还可以

产品编号 T15264 别名 CORT 125281Cas号 1781244-77-6

Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.

规格	价格	库存
25 mg	¥ 16,100	3-6月
50 mg	¥ 21,300	3-6月
100 mg	¥ 27,500	3-6月

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产品介绍

生物活性

产品描述	Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.
靶点活性	GR:（ki）7 nM
体外活性	Exicorilant reverses corticosterone-mediated GR activity in murine brown adipocytes [1].
体内活性	Exicorilant decreases fat mass, body weight, and plasma lipids in HFD-fed mice. Exicorilant (6, 20, or 60 mg/kg/d, for 3 weeks in mice) at different dosages reduce fat mass, body weight, plasma TG, cholesterol, and FFA in a dose-dependent manner. But it has no effect on lean mass [2].
别名	CORT 125281

化学信息

分子量	589.56
分子式	C₂₆H₂₃F₄N₇O₃S
CAS No.	1781244-77-6
密度	1.59 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 250 mg/mL (424.05 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6962 mL	8.4809 mL	16.9618 mL	84.8090 mL
5 mM	0.3392 mL	1.6962 mL	3.3924 mL	16.9618 mL
10 mM	0.1696 mL	0.8481 mL	1.6962 mL	8.4809 mL
20 mM	0.0848 mL	0.4240 mL	0.8481 mL	4.2405 mL
50 mM	0.0339 mL	0.1696 mL	0.3392 mL	1.6962 mL
100 mM	0.0170 mL	0.0848 mL	0.1696 mL	0.8481 mL