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Dalfopristin (mesylate) (112362-50-2 free base)
产品编号 T22707
别名 Dalfopristin (mesylate)
Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Streptogramin is often combined with type B streptogramin antibiotic, quinupristin, to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. The ribosome is composed of two ribonucleoprotein subunits, the 50S, and 30S. The 50S ribosome inhibitors inhibited protein synthesis.
Dalfopristin (mesylate) (112362-50-2 free base)
产品编号 T22707 别名 Dalfopristin (mesylate)
Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Streptogramin is often combined with type B streptogramin antibiotic, quinupristin, to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. The ribosome is composed of two ribonucleoprotein subunits, the 50S, and 30S. The 50S ribosome inhibitors inhibited protein synthesis.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 4,610 | 期货 | |
| 5 mg | ¥ 14,990 | 期货 |
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产品介绍
生物活性
化学信息
| 产品描述 | Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Streptogramin is often combined with type B streptogramin antibiotic, quinupristin, to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. The ribosome is composed of two ribonucleoprotein subunits, the 50S, and 30S. The 50S ribosome inhibitors inhibited protein synthesis. |
| 体外活性 | Dalfopristin is a cyclic polyunsaturated macrolactone that interferes with the binding of tRNA substrates to both A- and P-sites [2]. Dalfopristin blocked the access of peptidyl-tRNAs to the ribosome and peptidyltransferase elongation reaction in bacteria [1]. quinupristin and dalfopristin acted synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria [2][3]. Dalfopristin hydrolyzed rapidly to virginiamycin M under physiological conditions. |
| 别名 | Dalfopristin (mesylate) |
| 分子量 | 787 |
| 分子式 | C34H51N4O9S·CH3SO3 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度信息 | Ethanol: Soluble DMSO: Soluble |
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