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HedgehogIN-7 (Compound 8g),这是一种针对Hedgehog通路的嘌呤衍生抑制剂,可有效抑制Hedgehog信号传导并降低其基因表达。在胰腺癌细胞线Mia-PaCa-2中,HedgehogIN-7 显示出了显著的细胞毒性和高度选择性,因此适用于胰腺癌的相关研究。
HedgehogIN-7 (Compound 8g),这是一种针对Hedgehog通路的嘌呤衍生抑制剂,可有效抑制Hedgehog信号传导并降低其基因表达。在胰腺癌细胞线Mia-PaCa-2中,HedgehogIN-7 显示出了显著的细胞毒性和高度选择性,因此适用于胰腺癌的相关研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | HedgehogIN-7 (Compound 8g), a purine derivative, acts as an inhibitor of the Hedgehog signaling pathway by reducing the expression of Hedgehog genes and inhibiting signal transmission. This compound exhibits significant cytotoxicity and selectivity towards Mia-PaCa-2 pancreatic cancer cells that are dependent on the Hedgehog pathway, making it useful for research in pancreatic cancer. |
体外活性 | Hedgehog IN-7(Compound 8g)在MIA-PaCa-2细胞中展示出显著的细胞毒性(IC 50 = 4.11 μM),而在HEK293细胞中则表现出较低的细胞毒性(IC 50 > 50 μM)。此外,Hedgehog IN-7在NIH3T3 SHh-Light II细胞中能有效抑制Hedgehog信号传递,其IC 50 值达到6.4 μM。 |
分子量 | 482.56 |
分子式 | C27H27FN8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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