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4-Octylphenol 是一种环境激素干扰物,影响男性生殖细胞的性别特异功能,具体表现为显著降低有丝分裂指数与前精原细胞的数量。此外,4-Octylphenol 会导致鲤鱼出现鳃炎症,这一过程涉及补体系统的激活,包括补体成分 3a/补体成分 3a受体 (C3a/C3aR) 轴和补体成分 5a/补体成分 5a受体 1 (C5a/C5aR1) 轴。此化合物还通过调节 T 辅助细胞 (Th) 1/Th2 细胞平衡与调节性 T 细胞 (Treg)/Th17 细胞比例影响免疫系统。4-Octylphenol 亦可通过 Toll 样受体 7 (Toll-like Receptor (TLR))/抑制因子 κBα/核因子 κB (TLR7/IκBα/NF-κB) 路径产生炎症损伤。
4-Octylphenol 是一种环境激素干扰物,影响男性生殖细胞的性别特异功能,具体表现为显著降低有丝分裂指数与前精原细胞的数量。此外,4-Octylphenol 会导致鲤鱼出现鳃炎症,这一过程涉及补体系统的激活,包括补体成分 3a/补体成分 3a受体 (C3a/C3aR) 轴和补体成分 5a/补体成分 5a受体 1 (C5a/C5aR1) 轴。此化合物还通过调节 T 辅助细胞 (Th) 1/Th2 细胞平衡与调节性 T 细胞 (Treg)/Th17 细胞比例影响免疫系统。4-Octylphenol 亦可通过 Toll 样受体 7 (Toll-like Receptor (TLR))/抑制因子 κBα/核因子 κB (TLR7/IκBα/NF-κB) 路径产生炎症损伤。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | 4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway. |
分子量 | 206.32 |
分子式 | C14H22O |
CAS No. | 1806-26-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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