CCR7 Ligand 1

Name: CCR7 Ligand 1
Brand: TargetMol
SKU: T10716
Price: 597 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T10716Cas号 681514-83-0

别名 CCR7-Cmp2105

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.

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CCR7 Ligand 1

纯度: 无数据

产品编号 T10716 别名 CCR7-Cmp2105Cas号 681514-83-0

规格	价格	库存
2 mg	¥ 3,290	5日内发货
5 mg	¥ 5,390	5日内发货
25 mg	¥ 18,900	10-14周
50 mg	¥ 24,600	10-14周
100 mg	¥ 35,500	10-14周

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产品介绍

生物活性

产品描述	CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.
靶点活性	CCR7 (human):3 nM (kd)
体外活性	CCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8[1]. CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM[1]. CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7[1].
别名	CCR7-Cmp2105

化学信息

分子量	475.56
分子式	C₂₂H₂₉N₅O₅S
CAS No.	681514-83-0

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 12.5 mg/mL (26.28 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1028 mL	10.5139 mL	21.0278 mL	105.1392 mL
5 mM	0.4206 mL	2.1028 mL	4.2056 mL	21.0278 mL
10 mM	0.2103 mL	1.0514 mL	2.1028 mL	10.5139 mL
20 mM	0.1051 mL	0.5257 mL	1.0514 mL	5.2570 mL