TLR7 agonist 2

TLR7 agonist 2 (TLR7-IN-1) 是选择性 Toll 样受体 7 激动剂，LEC 值为 0.4 μM。

产品编号 T4258Cas号 1642857-69-9

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纯度:98.98%

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产品编号 T4258别名 TLR7-agonist-1, TLR7-IN-1Cas号 1642857-69-9

TLR7 agonist 2 (TLR7-IN-1) 是选择性 Toll 样受体 7 激动剂，LEC 值为 0.4 μM。

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生物活性

产品描述	TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
靶点活性	TLR7:LEC: 0.4 μM
细胞实验	The ability of TLR7-agonist-1 to activate human TLR7 and/or TLR8 is assessed by using HEK293 cells. Briefly, HEK293 cells are grown in culture medium (DMEM supplemented with 10% FCS and 2 mM Glutamine). Transfected cells are then detached with Trypsin-EDTA, washed in PBS and resuspended in medium to a density of 1.67×105 cells/mL. Thirty microliters of cells are then dispensed into each well in 384-well plates, where 10 μL of TLR7-agonist-1 in 4% DMSO is already present. Following 6 hours incubation at 37°C, 5% CO2, the luciferase activity is determined by adding 15 μL of Steady Lite Plus substrate to each well and readout performed on a microplate imager. Lowest effective concentrations (LEC) values are determined for TLR7-agonist-1.
动物实验	In C57Bl/6 mice model,Single oral administration of 0.3, 1, 3, and 10 mg/kg doses of TLR7-agonist-1.
别名	TLR7-agonist-1, TLR7-IN-1

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 45 mg/mL (133.79 mM)

溶液配制表

DMSO