1400W

Name: 1400W
Brand: TargetMol
SKU: T85385
Price: 2890 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T85385Cas号 180001-34-7

别名 W1400

1400W is a slow, tight-binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells and reduces the generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation [1] [2].

1400W

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产品编号 T85385 别名 W1400Cas号 180001-34-7

规格	价格	库存	数量
10 mg	询价	10-14周
50 mg	询价	10-14周

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产品介绍

生物活性

产品描述	1400W is a slow, tight-binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells and reduces the generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation [1] [2].
体外活性	1400W (60 μM, 1 h) 在原代成体小胶质细胞中降低了NO、3-NT与MDA的生成，并有效抑制了大脑皮层神经元的细胞凋亡 [2]。
体内活性	The compound 1400W (0.1-10 mg/kg, 皮下注射, 一次) inhibits ileal leakage in rats, with an EC50 of 0.16 mg/kg [1].
别名	W1400