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GSK163929 (compound 122) 是一种口服活性强的抗HIV CCR5拮抗剂,对hEGR的抑制效力较低。在 2000 mg/kg/day (i.v., 7 d) 的剂量下对大鼠无明显毒性,在 250 mg/kg/day (i.v., 7 d) 的剂量下对狗也未见不良反应。
GSK163929 (compound 122) 是一种口服活性强的抗HIV CCR5拮抗剂,对hEGR的抑制效力较低。在 2000 mg/kg/day (i.v., 7 d) 的剂量下对大鼠无明显毒性,在 250 mg/kg/day (i.v., 7 d) 的剂量下对狗也未见不良反应。
产品描述 | GSK163929 (compound 122) is an orally active CCR5 antagonist with anti-HIV properties and demonstrates low inhibitory potency against hEGR. Administered at a dosage of 2000 mg/kg/day (i.v., 7 d), it shows no adverse effects in rats, and at 250 mg/kg/day (i.v., 7 d), it is similarly non-toxic in dogs. |
分子量 | 696.25 |
分子式 | C36H40ClF2N5O3S |
CAS No. | 716354-04-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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