DS-437

Name: DS-437
Brand: TargetMol
SKU: T15169
Rating: 4.5 (1 reviews)

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产品编号 T15169Cas号 1674364-87-4

DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.

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DS-437

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产品编号 T15169Cas号 1674364-87-4

DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.

规格	价格	库存
2 mg	¥ 397	5日内发货
5 mg	¥ 663	5日内发货
10 mg	¥ 1,280	5日内发货
100 mg	¥ 5,820	6-8周
1 mL x 10 mM (in DMSO)	¥ 728	5日内发货

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产品描述	DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.
体外活性	DS-437 increased total CD8+?and CD8+ PD-1+ T cells [2]. DS-437 was able to inhibit the methylation of an H4[1–24] peptide by the PRMT5–MEP50 complex under balanced conditions (cofactor and substrate concentrations set at their respective?Km?values) in a dose-dependent manner (IC50: 5.9 μM) [1].
体内活性	The combination of DS-437 and the anti-p185erbB2/neu?antibody 4D5 had even more dramatic effects. DS-437 (10 mg/kg; i.p.; 5 times a week) has some beneficial effects on inhibiting tumor growth [1].