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Search Results for " dna "

Targets Recommended: DNA/RNA Synthesis DNA Methyltransferase DNA DNA Alkylation DNA Alkylator/Crosslinker DNA gyrase DNA-PK Antiviral DNA/RNA Synthesis

1633

抑制剂 & 化合物

297

天然产物

15

化合物库

3

TargetMol 试剂盒

345

重组蛋白

38

同位素标记化合物

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Cat. No.	Product Name
L3900	DNA 损伤和修复分子库		910 compounds
	910 个与 DNA 损伤和修复紧密相关的化合物集合，是高通量筛选，高内涵筛选的良好载体；
L3980	DNA损伤/修复库Plus		667 compounds
	667 种 DNA 损伤/修复靶向、结构新颖的化合物；
L3510	甲基化化合物库		128 compounds
	128 种甲基化相关的化合物，可以用于高通量和高内涵筛选；
L1200	表观遗传库		953 compounds
	953 种表观遗传学研究相关的生物活性小分子的特有集合，用于表观遗传学研究及其相关的检测和高通量、高内涵筛选；
L5500	毒性化合物库		262 compounds
	262 个细胞毒性化合物的特有集合，可用于高通量、高内涵筛选。
L1380	转录因子库		695 compounds
	695 种转录因子靶向、结构新颖的化合物；
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L8100	细胞周期化合物库		677 compounds
	677 种细胞周期相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L8300	染色质修饰分子库		250 compounds
	250 种染色质化学修饰相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L1510	核受体化合物库		531 compounds
	531 个核受体作用化合物的独特集合，可用于高通量筛选和高内涵筛选；
L3500	组蛋白修饰化合物库		469 compounds
	469 个组蛋白修饰相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L8600	泛素化化合物库		210 compounds
	210 种泛素化相关的小分子，用于高通量和高内涵筛选；
L5300	线粒体靶向库		812 compounds
	812 种具有潜在或确定线粒体靶向活性的化合物，以促进针对线粒体的药物研究；
L2910	抗氧化化合物库		1314 compounds
	氧化应激（Oxidative Stress，OS）是指体内氧化与抗氧化作用失衡的一种状态。氧化应激导致活性氧（ROS）大量积累，氧化程度超出抗氧化物的清除能力，从而引起氧化损伤，氧化应激损伤是许多疾病发生的基础，不同程度的氧化应激造成的细胞效应与心脑血管疾病、神经退行性病变、炎症和肿瘤密切相关。抗氧化剂是一类能够对抗氧化应激，降低氧化损伤的一类化合物。 TargetMol 抗氧化化合物库是1314 种对氧化应激具有抑制作用的小分子特有集合，是研究氧化应激的有用工具，可以用于高通量筛选和高内涵筛选。
L6120	黄酮类天然产物库		514 compounds
	514 种黄酮类天然产物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

DNA 损伤和修复分子库

Cat.No: L3900

Compounds: 910

DNA损伤/修复库Plus

Cat.No: L3980

Compounds: 667

甲基化化合物库

Cat.No: L3510

Compounds: 128

表观遗传库

Cat.No: L1200

Compounds: 953

毒性化合物库

Cat.No: L5500

Compounds: 262

转录因子库

Cat.No: L1380

Compounds: 695

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

细胞周期化合物库

Cat.No: L8100

Compounds: 677

染色质修饰分子库

Cat.No: L8300

Compounds: 250

核受体化合物库

Cat.No: L1510

Compounds: 531

组蛋白修饰化合物库

Cat.No: L3500

Compounds: 469

泛素化化合物库

Cat.No: L8600

Compounds: 210

线粒体靶向库

Cat.No: L5300

Compounds: 812

抗氧化化合物库

Cat.No: L2910

Compounds: 1314

黄酮类天然产物库

Cat.No: L6120

Compounds: 514

Cat. No.	Product Name	Form	Specificity Of Inhibition
C0008	SYBR Green qPCR Master Mix (Low ROX) SYBR Green qPCR Master Mix (Low ROX)	Solution in bottle
C0006	SYBR Green qPCR Master Mix (No ROX) SYBR Green qPCR Master Mix (No ROX)	Solution in bottle
C0007	SYBR Green qPCR Master Mix (High ROX) SYBR Green qPCR Master Mix (High ROX)	Solution in bottle

TargetMol 试剂盒

SYBR Green qPCR Master Mix (Low ROX)

Cat.No: C0008

SYBR Green qPCR Master Mix (No ROX)

Cat.No: C0006

SYBR Green qPCR Master Mix (High ROX)

Cat.No: C0007

Cat. No.	Product Name	Target	Signaling Pathways
T80644	DNA polymerase-IN-1	Antiviral; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation
	DNA polymerase-IN-1 作为DNA聚合酶抑制剂，展现出对肿瘤细胞的抗增殖活性，其半抑制浓度（IC50）为20.7 μM。DNA polymerase-IN-1 抑制 Taq DNA 聚合酶，IC 值低于 250μM。DNA polymerase-IN-1 通过RT-PCR检测在体外显示出抗逆转录病毒活性，可用于研究氧化损伤和结直肠癌。
T3103	L67 DNA Ligase Inhibitor	DNA; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	L67 (DNA Ligase Inhibitor) 是一种竞争性人类 DNA 连接酶抑制剂，抑制 DNA 连接酶 I 和 III，IC50为10μM。
T31554	DNA-Spermidine DA-51,DA 51,DA51,DNA Spermidine	Others	Others
	DNA-spermidine influences the activity of restricted endonuclease from several bacterial species.
T1904	SGI-1027 DNA Methyltransferase Inhibitor II,SGI1027	Apoptosis; DNA Methyltransferase	Apoptosis; Chromatin/Epigenetic
	SGI-1027 (DNA Methyltransferase Inhibitor II) 是一种 DNA 甲基转移酶(DNMT)抑制剂，对以 poly(dI-dC) 为底物的 DNMT3B，DNMT3A 和 DNMT1 的IC50值分别为 7.5 μM，8 μM 和 12.5 μM。
T2433	NU 7026 NU7026,DNA-PK Inhibitor II,LY293646	Apoptosis; ATM/ATR; DNA-PK; PI3K	Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	NU 7026 (DNA-PK Inhibitor II) 是一种新型特异性的DNA-PK 抑制剂，IC50为 0.23 μM，也抑制PI3K，IC50为 13 μM。
T15146	DNA2 inhibitor C5	Others	Others
	DNA2 inhibitor C5 是竞争性特异性的DNA2 核酸酶活性抑制剂(IC50:20 μM)。它能够抑制DNA 依赖性 ATPase、 DNA2 的核酸酶、解旋酶和 DNA 结合活性。它可用于研究奥正癌症。
T27194	DNA Primase Inhibitor-13	Others	Others
	DNA Primase Inhibitor-13 is a novel inhibitor of DNA primase.
T63442	DNA Gyrase-IN-2	Others	Others
	DNA Gyrase-IN-2 是细菌 DNA 促旋酶 B 抑制剂，能作用于大肠杆菌 DNA 促旋酶(IC50: 3.29-10.49 μM)和结核分枝杆菌 DNA 促旋酶(IC50: 4.41-5.61 μM)，表现出抗菌和抗结核作用。
T60961	LANA-DNA-IN-1	Others	Others
	LANA-DNA-IN-1 是 LANA-DNA 的有效抑制剂，对 LBS2、LBS1 和 LBS3 的 IC50值分别为 8 μM、9μM 和 8μM。 LANA-DNA-IN-1 对野生型 LANA 显示出 53 μM 的 IC50值。LANA-DNA-IN-1 可用于研究感染。
T74340	DNA crosslinker 4 dihydrochloride	Others	Others
	DNA crosslinker 4 (dihydrochloride) 作为高效的DNA小沟结合剂，对NCI-H460、A2780和MCF-7癌细胞表现出显著抑制活性，适用于抗癌研究。
T74338	DNA crosslinker 2 dihydrochloride	Others	Others
	DNA crosslinker 2 (dihydrochloride)为一种高效DNA小沟结合剂，其结合亲和力(ΔTm)达1.2°C。该化合物对NCI-H460、A2780及MCF-7癌细胞展示出抑制活性，适用于抗癌研究。
T79922	Taq DNA polymerase	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Taq DNA 聚合酶是一种在PCR过程中广泛使用的耐热性酶，由Thermus aquaticus细菌产生，其功能是在高温下合成DNA链。
T79240	DNA gyrase B-IN-2	Others	Others
	DNA gyrase B-IN-2 (Compound E) 是一款基于2-aminobenzothiazole的DNA gyrase B抑制剂，针对ESKAPE病原体显示出强效活性。该化合物在低纳摩尔浓度下表现出优异的DNA gyrase B抑制能力(IC50< 10 nM)，具备对多种ESKAPE病原体的广谱抗菌作用。对于大部分革兰氏阳性菌，最低抑菌浓度(MIC)低于0.03 μg/mL；针对革兰氏阴性病原体如E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa和Klebsiella pneumoniae，MIC为4 - 16 μg/mL。此化合物适用于感染性疾病的研究应用。
T63681	DNA Gyrase-IN-1	Others	Others
	DNA Gyrase-IN-1 是有效的、选择性的 DNA 促旋酶抑制剂 (IC50: 2.6 μM)。DNA Gyrase-IN-1 能够较好的抑制结核分枝杆菌 (Mtb) 的活性 (MIC: 0.49 μM)。DNA Gyrase-IN-1 能够用于研究结核病。
T74337	DNA crosslinker 1 dihydrochloride	Others	Others
	DNA crosslinker 1 (dihydrochloride)作为有效DNA小沟结合剂,具有1.1°C的结合亲和力（ΔTm），适用于抗癌研究。
T79308	DNA polymerase-IN-3	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA polymerase-IN-3 (Compd 5b) 为香豆素衍生物，对 Taq DNA聚合酶具有抑制活性，适用于增值性疾病研究。
T61828	DNA-PK-IN-8	Others	Others
	DNA-PK-IN-8（化合物DK1）是一种高效、选择性且口服活性的DNA依赖蛋白激酶 (DNA-PK) 抑制剂，其IC50值为0.8 nM。与Doxorubicin联合应用时，该化合物能在多种癌细胞中展现出协同的抗增殖效应，并能显著地抑制HL-60肿瘤生长。
T81953	LANA-DNA-IN-2	Others	Others
	LANA-DNA-IN-2 (Compound 20) 是抑制潜伏期相关核抗原 (LANA) 与 DNA 相互作用的化合物。它适用于研究卡波西肉瘤相关疱疹病毒 (KSHV) 感染。
T74848	DNA Gyrase-IN-6	Others	Others
	Antibacterial agent 138 是细菌 DNA 促旋酶和拓扑异构酶 IV 的苯并噻唑抑制剂。Antibacterial agent 138 表现出良好的溶解度和血浆蛋白结合。Antibacterial agent 138 对革兰氏阳性和革兰氏阴性菌株具有抗菌活性。Antibacterial agent 138 是一种双重 GyrB 和 ParE 抑制剂。
T62191	DNA-PK-IN-5	Others	Others
	DNA-PK-IN-5 是一种 DNA-PK 的有效抑制剂。DNA-PK-IN-5 能够抑制 DNA-PKcs 活性，明显降低肿瘤 DNA 修复，并诱导细胞凋亡。DNA-PK-IN-5 能够提高肿瘤组织对放疗的敏感性，克服耐药问题，提高对多种实体瘤和血液肿瘤的抑制效果。
T62034	DNA-PK-IN-7	Others	Others
	DNA-PK-IN-7 是有效的 DNA-PK 抑制剂，IC50为 1 nM (WO2021104277A1, compound 5)。
T78712	DNA Gyrase-IN-8	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA Gyrase-IN-8是一种高效的DNA gyrase抑制剂，其IC50为8.45 µM，同时展现出了抗菌活性。
T63395	DNA Gyrase-IN-5	Others	Others
	DNA Gyrase-IN-5 是 DNA gyrase 的有效抑制剂 (IC50: 0.10 μM)，对野生型和耐药株均有抗细菌（antibacterial）作用。
T62895	DNA Gyrase-IN-4	Others	Others
	DNA Gyrase-IN-4 (compound 8p) 是一种 DNA 促旋酶的有效抑制剂 (IC50: 0.13 μM)。DNA Gyrase-IN-4 对金黄色葡萄球菌 (MIC: 0.05 μg/ml)、单核增生李斯特菌 (MIC: 0.05 μg/ml)、沙门氏菌 (MIC: 0.05 μg/ml) 和大肠杆菌 (MIC: 8 μg/ml) 具有较好的抗菌作用。
T82536	DNA polymerase-IN-4	Others	Others
	DNA polymerase-IN-4 (Compd 5c)，香豆素衍生物，显示出抗逆转录病毒活性，IC50为134.22 μM。
T61857	DNA-PK-IN-4	Others	Others
	DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly impairs tumor DNA repair mechanisms and triggers apoptosis in cells. With its potential application in cancer research, DNA-PK-IN-4 holds promise for further investigation [1].
T61533	DNA-PK-IN-9	Others	Others
	DNA-PK-IN-9 (also known as compound YK6) is a highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), displaying an IC50 value of 10.47 nM. DNA-PK-IN-9 holds significant potential in anticancer research [1].
T61370	DNA-PK-IN-6	Others	Others
	DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 amplifies the responsiveness of tumor tissues to radiotherapy, overcomes the challenge of drug resistance, and augments its inhibitory impact on a diverse range of solid and hematological tumors[1].
T79165	DNA-PK-IN-10	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	DNA-PK-IN-10是一种DNA-PK抑制剂, 主要应用于乳腺癌与非小细胞肺癌的研究。
T78866	DNA Gyrase-IN-9	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA Gyrase-IN-9 (compound 4j) 是一款抗细菌剂，作用于 DNA gyrase。该化合物对抑制革兰氏阳性菌的最小抑菌浓度（MIC）范围为 0.5-2 μg/mL，最小杀菌浓度（MBC）为 2-8 μg/mL。在金黄色葡萄球菌中，DNA Gyrase-IN-9 的 DNA gyrase 抑制半数有效浓度（IC50）为 6.29 μg/mL。
T85267	DNA-PK Inhibitor IV	Others	Others

T61937	DNA Gyrase-IN-3	Others	Others
	DNA Gyrase-IN-3 (Compound 28) 是细菌DNA 旋转酶 B (bacterial DNA gyrase B) 抑制剂。DNA Gyrase-IN-3抑制大肠杆菌DNA 旋转酶的 IC50为5.41-15.64 μM。DNA Gyrase-IN-3显示出抗结核和抗菌活性。
T61633	DNA-PK-IN-2	Others	Others
	DNA-PK-IN-2 is a highly effective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a complex enzyme composed of Ku70/Ku80 heterodimer and DNA-PK catalytic subunit (DNA-PKcs). With its potential applications in cancer research, DNA-PK-IN-2 demonstrates promise as a valuable tool for studying cancer diseases [1].
T62648	DNA-PK-IN-1	Others	Others
	DNA-PK-IN-1 是一种 DNA-PK 的有效抑制剂。DNA 依赖性蛋白激酶 (DNA-PK) 是一种由 Ku70/Ku80 异二聚体和 DNA 依赖性蛋白激酶催化亚基 (DNA-PKcs) 组成的 DNA-PK 酶复合物。DNA-PK-IN-1 具有潜力进行癌症疾病的研究。
T61751	DNA-PK-IN-3	Others	Others
	DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tumor growth. Furthermore, DNA-PK-IN-3 demonstrates remarkable efficacy in reducing damage to normal cells, effectively minimizing adverse side effects. Due to these compelling properties, DNA-PK-IN-3 holds great potential for cancer research applications[1].
T74339	DNA crosslinker 3 dihydrochloride	Others	Others
	DNA crosslinker 3 (dihydrochloride) (compound 1) 为一种与DNA结合的小沟结合剂，其结合亲和力(ΔTm)达1.4°C，常用于抗癌研究。
T79307	DNA polymerase-IN-2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA polymerase-IN-2 (Compd 3c)为香豆素衍生物，对Taq DNA聚合酶具有抑制作用，IC50为48.25 μM，适用于增殖性疾病研究。
T12019	Methylproamine	Others	Others
	Methylproamine是一种与DNA结合的辐射保护剂，可以修复辐射诱导的短暂活性氧。
T4517	L189	DNA; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	L189 是一种人类 DNA 连接酶抑制剂，抑制 hLigI/III/IV，IC50值分别为5、9 和 5 μM。
T8873	Bractoppin	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂，IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募，进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。
T63360	DNA topoisomerase II inhibitor 1	Others	Others
	DNA topoisomerase II inhibitor 1 是 DNA 拓扑异构酶 II 的有效抑制剂，能够将细胞周期停滞在亚 G1 期，并诱导细胞凋亡 (apoptosis) ，具有抗增值作用。
T64012	DNA gyrase B-IN-1	Others	Others
	DNA gyrase B-IN-1 是 DNA gyrase B 的有效抑制剂，表现出良好的结合亲和力和稳定性。DNA gyrase B-IN-1 能够抑制 P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM)。
T78776	DNA gyrase B-IN-3	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA gyrase B-IN-3（Compound A），作为一种细菌DNA gyrase B抑制剂（IC50: <10 nM），针对革兰氏阳性菌株表现出抗菌活性。
T11469	GSK-3484862	DNA Methyltransferase	Chromatin/Epigenetic
	GSK-3484862 是有效的 DNA 甲基转移酶 Dnmt1的非共价抑制剂。GSK-3484862 通过诱导 DNA 低甲基化起抗癌作用。GSK-3484862 介导小鼠胚胎干细胞的整体去甲基化。
T15080	DC-05	DNA Methyltransferase; Histone Methyltransferase	Chromatin/Epigenetic
	DC-05 是一种DNMT1的抑制剂，IC50和Kd 值分别为 10.3 和 1.09 μM。
T36757	DMT-dU-CE Phosphoramidite	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DMT-dU-CE Phosphoramidite 是一个核苷分子，通常用于合成 DNA 和 DNA 测序试验。
T62389	14α-Demethylase/DNA Gyrase-IN-2	Others	Others
	14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂，具有抗菌作用。
T0164	Oxaliplatin L-OHP,奥沙利铂	DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Oxaliplatin (L-OHP) 是一种 DNA 烷化剂，一种 DNA 合成抑制剂。Oxaliplatin 会导致 DNA 交联损伤，阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 可以诱导细胞自噬。
T4339	YU238259	DNA-PK; Others	DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
	YU238259 是一种新型的同源依赖性 DNA 修复 (HDR) 抑制剂，在基于细胞的 GFP 报告基因检测中不抑制非同源末端连接 (NHEJ)，可研究癌症。
T62792	14α-Demethylase/DNA Gyrase-IN-1	Others	Others
	14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂，具有抗菌作用。

化合物

DNA polymerase-IN-1

Cat.No: T80644

Target: Antiviral, DNA/RNA Synthesis

Cat.No: T3103

Synonym: DNA Ligase Inhibitor

Target: DNA, DNA/RNA Synthesis

DNA-Spermidine

Cat.No: T31554

Synonym: DA-51,DA 51,DA51,DNA Spermidine

Target: Others

Cat.No: T1904

Synonym: DNA Methyltransferase Inhibitor II,SGI1027

Target: Apoptosis, DNA Methyltransferase

Cat.No: T2433

Synonym: NU7026,DNA-PK Inhibitor II,LY293646

Target: Apoptosis, ATM/ATR, DNA-PK, PI3K

DNA2 inhibitor C5

Cat.No: T15146

Target: Others

DNA Primase Inhibitor-13

Cat.No: T27194

Target: Others

DNA Gyrase-IN-2

Cat.No: T63442

Target: Others

LANA-DNA-IN-1

Cat.No: T60961

Target: Others

DNA crosslinker 4 dihydrochloride

Cat.No: T74340

Target: Others

DNA crosslinker 2 dihydrochloride

Cat.No: T74338

Target: Others

Taq DNA polymerase

Cat.No: T79922

Target: DNA/RNA Synthesis

DNA gyrase B-IN-2

Cat.No: T79240

Target: Others

DNA Gyrase-IN-1

Cat.No: T63681

Target: Others

DNA crosslinker 1 dihydrochloride

Cat.No: T74337

Target: Others

DNA polymerase-IN-3

Cat.No: T79308

Target: DNA/RNA Synthesis

Cat.No: T61828

Target: Others

LANA-DNA-IN-2

Cat.No: T81953

Target: Others

DNA Gyrase-IN-6

Cat.No: T74848

Target: Others

Cat.No: T62191

Target: Others

Cat.No: T62034

Target: Others

DNA Gyrase-IN-8

Cat.No: T78712

Target: DNA/RNA Synthesis

DNA Gyrase-IN-5

Cat.No: T63395

Target: Others

DNA Gyrase-IN-4

Cat.No: T62895

Target: Others

DNA polymerase-IN-4

Cat.No: T82536

Target: Others

Cat.No: T61857

Target: Others

Cat.No: T61533

Target: Others

Cat.No: T61370

Target: Others

Cat.No: T79165

Target: DNA-PK

DNA Gyrase-IN-9

Cat.No: T78866

Target: DNA/RNA Synthesis

DNA-PK Inhibitor IV

Cat.No: T85267

Target: Others

DNA Gyrase-IN-3

Cat.No: T61937

Target: Others

Cat.No: T61633

Target: Others

Cat.No: T62648

Target: Others

Cat.No: T61751

Target: Others

DNA crosslinker 3 dihydrochloride

Cat.No: T74339

Target: Others

DNA polymerase-IN-2

Cat.No: T79307

Target: DNA/RNA Synthesis

Cat.No: T12019

Target: Others

Cat.No: T4517

Target: DNA, DNA/RNA Synthesis

Cat.No: T8873

Target: Others, DNA/RNA Synthesis

DNA topoisomerase II inhibitor 1

Cat.No: T63360

Target: Others

DNA gyrase B-IN-1

Cat.No: T64012

Target: Others

DNA gyrase B-IN-3

Cat.No: T78776

Target: DNA/RNA Synthesis

Cat.No: T11469

Target: DNA Methyltransferase

Cat.No: T15080

Target: DNA Methyltransferase, Histone Methyltransferase

DMT-dU-CE Phosphoramidite

Cat.No: T36757

Target: DNA/RNA Synthesis

14α-Demethylase/DNA Gyrase-IN-2

Cat.No: T62389

Target: Others

Cat.No: T0164

Synonym: L-OHP,奥沙利铂

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

Cat.No: T4339

Target: DNA-PK, Others

14α-Demethylase/DNA Gyrase-IN-1

Cat.No: T62792

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T13592	Calf thymus DNA DNA from calf thymus, Thymonucleic acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Calf thymus DNA (DNA from calf thymus, Thymonucleic acid) 是一种从牛胸腺中提取出来的高质量双链模板DNA，可广泛应用于DNA 结合抗癌剂和调节DNA 结构和功能的DNA 结合剂的研究。
T21498	Phleomycin	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Phleomycin 是在链霉菌中发现的，引起 DNA 切割的抗癌糖肽抗生素之一。它类似于博来霉素，它结合并插入 DNA 以破坏双螺旋的完整性。
T1068	Dithranol 1,8,9-trihydroxyanthracene,cignoline,蒽林,Anthralin	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Dithranol (cignoline) 是蒽醌衍生物，可破坏线粒体功能和结构，用于治疗皮肤病。
T37101	1-Hydroxyanthraquinone	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	1-Hydroxyanthraquinone 是口服有效的天然产物，来源于植物 Tabebuia avellanedae，显示出致癌活性。
T7520	Deoxycytidine triphosphate	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Deoxycytidine triphosphate 是一种核苷三磷酸，是合成 DNA 的原料，可用于实时荧光定量 PCR、cDNA 合成和 DNA 测序。
T6S0139	Neobavaisoflavone	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎，抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶，也可抑制血小板聚集。
T13969	Xanthopterin (hydrate)	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Xanthopterin hydrate 是东方大黄蜂翅膀中黄色颗粒的主要成分，是一种非共轭的蝶啶天然产物，在 386/456 nm 处产生特征性的激发光。它可抑制 RNA 合成，引起大鼠肾脏生长和肥大。
TN2132	Quinizarin 1,4-Dihydroxyanthraquinone,1,4-二羟基蒽醌	Others; DNA/RNA Synthesis; Antifungal	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Quinizarin (1,4-Dihydroxyanthraquinone) 是一种杀菌剂和杀虫剂，可抑制肿瘤细胞生长。
T40179	Sodium Camptothecin	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Sodium Camptothecin 是一种植物生物碱，具有抗肿瘤活性。它是可逆 RNA 合成抑制剂，可以抑制腺病毒的复制。它能抑制 DNA 合成，并引起细胞内预形成的病毒 DNA 断裂。
T12651	Rabdosiin (+)-Rabdosiin	Others	Others
	Rabdosiin ((+)-Rabdosiin) 是一种分离自 Rabdosia japonicaHara 中的咖啡酸四聚体，具有抗过敏、抗 HIV 和抑制 DNA 拓扑异构酶作用。
T0064	Adenine Vitamin B4,腺嘌呤,6-Aminopurine	DNA/RNA Synthesis; Endogenous Metabolite; AChR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Neuroscience
	Adenine (6-Aminopurine) 是一种嘌呤衍生物，是一种核碱基。它在细胞呼吸、以富含能量的 ATP 和 NAD 和 FAD 的形式和蛋白质合成作用，作为 DNA 和 RNA 的化学成分。
TWP2911	Thymidine beta-胸苷,5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Thymidine (DThyd) 是一种细胞同步剂，是脱氧核糖核酸的特殊前体。它可在 DNA 复制前在 G1/S 边界阻滞细胞，是DNA 合成抑制因子。
T2S1635	3-Isomangostin	MTH1	DNA Damage/DNA Repair
	3-Isomangostin 可从莽吉柿壳中提取的一种天然产物，是一种乙酰胆碱酯酶选择性抑制剂，也是一种有效的人醛糖还原酶抑制剂，IC50 为 3.48 uM。它抑制 MutT 同源物 1 (MTH1)，IC50 为 52 nM。它具有清除自由基、抗疟原虫和抗癌的活性。
T5270	5-Methylcytosine	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	5-Methylcytosine 是一种存在于真核 DNA 中的甲基化核苷酸碱基。它是由 DNA 甲基转移酶作用形成的表观遗传修饰。
TN1134	Euscaphic acid	Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
	Euscaphic acid 是来源于枣的一种三萜，是DNA 聚合酶抑制剂，可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。
T3606	γ-Oryzanol 谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza	DNA Methyltransferase	Chromatin/Epigenetic
	γ-Oryzanol (Gamma-Oryzanol) 是一种从米糠油中分离出来的营养提取物，是含有甾醇和阿魏酸的混合物，有助于破坏皮肤中的自由基。它有效抑制小鼠纹状体中的 DNA 甲基转移酶(DNMTs)。它抑制DNMT1和DNMT3a，IC50分别为 3.2 和 22.3 μM。
T3717	Hinokitiol 4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇	DNA Methyltransferase; Virus Protease; Estrogen/progestogen Receptor; Nrf2	Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
	Hinokitiol (4-Isopropyltropolone) 是从日本扁柏中分离到的一种挥发油成分，可抑制紫外线 B 诱导的角质形成细胞凋亡，可调节雌激素受体信号传导并抑制人乳腺癌细胞的增殖。它具有抗感染、抗氧化及抗肿瘤等活性。
T5901	3-Hydroxy-2-methylpyridine	Others	Others
	3-Hydroxy-2-methylpyridine 是分离自可可碱提取物，可用于合成嘧啶。
T7457	5-Methyl-2'-deoxycytidine 5-Methyldeoxycytidine,5-甲基-2'-脱氧胞苷,5MedCyd	DNA Methyltransferase; Endogenous Metabolite	Chromatin/Epigenetic; Metabolism
	5-Methyl-2'-deoxycytidine (5MedCyd) 是嘧啶核苷，当掺入到单链 DNA 中时，可以顺式作用以从头发出信号。
T6567	Levofloxacin Levaquin,Cravit,Tavanic,Fluoroquinolone,左氧氟沙星,(-)-Ofloxacin	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Levofloxacin (Fluoroquinolone) 是合成的氟喹诺酮类抗生素，有抑制细菌DNA 旋转酶的超螺旋活性的作用，能阻止DNA 复制。
T35455	N-Nitrosodiethylamine Diethylnitrosamine,NDEA	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	N-Nitrosodiethylamine (NDEA) 是致癌物质二烷基硝胺。它主要存在于水、烟草烟雾、腌制食品、油炸食品以及许多酒精饮料中。它与 DNA 修复/复制相关的核酶的变化相关。
T6225	Adenine hydrochloride Adenine HCl,腺嘌呤盐酸盐,6-Aminopurine hydrochloride	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Adenine hydrochloride (6-Aminopurine hydrochloride) 是一种嘌呤，是一种核碱基。它在细胞呼吸、以富含能量的 ATP 和 NAD 和 FAD 的形式和蛋白质合成作用，作为 DNA 和 RNA 的化学成分。
TN3110	5-Geranoxy-7-methoxycoumarin	Anti-infection; Antibacterial; Antifungal	Microbiology/Virology
	5-Geranoxy-7-methoxycoumarin 是一种香豆素。它诱导细胞凋亡，具有抗癌、抗真菌和抗菌活性。
TQ0184	Chebulinic acid	ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells
	Chebulinic acid 是从诃子果中提取的一种天然产物，结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。
T6S0232	Eriodictyol 圣草酚,Huazhongilexone	Influenza Virus; DNA/RNA Synthesis; Nrf2; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Eriodictyol (Huazhongilexone) 是从中草药中得到的一种黄酮类天然产物，具有抗氧化、抗炎和抗糖尿病作用。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂，IC50为 18 nM。它可诱导Nrf2信号通路。
T1339	5-Azacytidine 阿托胞苷,Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-氮杂胞苷,5-AzaC	Nucleoside Antimetabolite/Analog; DNA Methyltransferase; Antibacterial; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	5-Azacytidine (Ladakamycin) 是一种胞苷核苷类似物，一种 DNA 甲基化抑制剂，具有特异性。5-Azacytidine 通过降低 DNA 甲基化水平调节基因表达。5-Azacytidine 可以诱导细胞自噬，具有抗肿瘤活性。
T1508	Decitabine Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA Methyltransferase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Decitabine (Deoxycytidine) 是脱氧胞苷类似物，一种 DNA 甲基转移酶抑制剂，具有口服活性。Decitabine 具有抗肿瘤活性和抗代谢活性。Decitabine 诱导细胞周期阻滞和凋亡。
T13229	Tunicamycin	Influenza Virus; Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Tunicamycin 是一种抗生素的混合物，通过阻断 GlcNAc 磷酸转移酶 (GPT)，抑制 N-连接糖基化。Tunicamycin 具有抗肿瘤活性，还具有抗细菌、抗真菌和抗病毒活性。
T3332	Isosteviol 异甜菊醇,(-)-Isosteviol	IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。
T0974	Novobiocin Sodium Albamycinsodium,新生霉素钠,Cathomycin,Albamycin	Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology
	Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。
T1507	Streptozocin STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889	DNA Alkylator/Crosslinker; DNA Alkylation; DNA/RNA Synthesis; Antibacterial; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Streptozocin (NSC-85998) 是一种抗生素，可诱导 DNA 甲基化。Streptozocin 对产生胰岛素的胰岛 B 细胞具有毒性，常用于构建 1 型糖尿病的动物模型。该产品在溶液中不稳定，建议现配现用。
T6369	Adenine hemisulfate 硫酸腺嘌呤,Diadenine sulphate,Adenine sulfate,Adeninsulfat,1H-嘌呤-6-胺硫酸盐	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Adenine hemisulfate (Diadenine sulphate) 是一种嘌呤，是一种核碱基。它在细胞呼吸、以富含能量的 ATP 和 NAD 和 FAD 的形式和蛋白质合成作用，作为 DNA 和 RNA 的化学成分。
T16674	Pseudouridine	Endogenous Metabolite	Metabolism
	Pseudouridine 是非编码 RNA 中丰富的修饰核苷，通过稳定 RNA 结构增强核糖体 RNA 和的转移 RNA 功能。
T4593	ISOPIMPINELLIN 5,8-Dimethoxypsoralen,异茴芹内酯,4,9-Dimethoxypsoralen	Antiviral; DNA/RNA Synthesis; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology
	Isopimpinellin (4,9-Dimethoxypsoralen) 是从 Pimpinella saxifrage 根部分离得到的一种天然产物，具有抗病毒和抗利什曼病活性。
TN1637	Eurycomalactone	Anti-infection; NF-κB	Microbiology/Virology; NF-κB
	Eurycomalactone 是一种NF-κB 抑制剂，IC50=0.5 μM，是一种天然产物。它可抑制蛋白合成，降低 cyclin D1 蛋白水平，但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。
T9715	Aplidine	SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性，抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤，晚期癌症及 COVID-19 领域有研究的价值。
TWS1977	Kamebakaurin 尾叶香茶菜丙素,Kamebakaurine	NF-κB	NF-κB
	Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物，是一种NF-κB 的抑制剂，能够抑制 p50 的 DNA 结合活性。
T2998	Dihydromyricetin Ampelopsin,Ampeloptin,二氢杨梅素	Influenza Virus; GABA Receptor; DNA/RNA Synthesis; mTOR; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Dihydromyricetin (Ampelopsin) 是一种来自 Ampelopsis Grossedentata 的天然抗氧化剂类黄酮，是二氢嘧啶酶抑制剂，IC50 为 48 μM。它通过抑制mTOR 信号从而激活自噬。它还是流感依赖 RNA 的RNA 聚合酶抑制剂，IC50为 22 μM。
T6995	Ochromycinone STA 21,STA21,STA-21	Antibacterial; STAT	JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Ochromycinone (STA 21) 是一种天然抗生素，也是一种 STAT3抑制剂。它可抑制 STAT3DNA 结合活性，STAT3二聚化。它具有抗癌和抗菌活性。
T4558	Trioxsalen 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen	DNA Alkylator/Crosslinker; DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Trioxsalen (Trioxysalen) 是一种呋喃香豆素和补骨脂素衍生物，与 UV-A 一起用于光疗治疗白癜风和手部湿疹。它是一种光化学 DNA 交联剂，可用于激光激活定位的基因组链间交联可视化。
T13791	N2-methylguanine 6-羟基-2-氨甲基嘌呤	DNA/RNA Synthesis; Endogenous Metabolite; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	N2-methylguanine (N2-methylguanine) 是一种在人体体液中发现的内源性甲基化核苷，是一种修饰的核苷。
T7004	Tubercidin 结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine	Influenza Virus; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Tubercidin (Sparsomycin A) 是从Streptomyces tubercidicus 得到的抗生素，抑制粪链球菌生长的IC50值为 0.02 μM。它是腺苷磷酸化酶的弱抑制剂，并干扰腺苷和 AMP 的磷酸化。它有抗病毒作用。
T5368	Eicosapentaenoic Acid	Histone Demethylase; Others; Endogenous Metabolite	Chromatin/Epigenetic; Metabolism; Others
	Eicosapentaenoic Acid 是一种 ω-3 脂肪酸。
T6116	Bleomycin Sulfate Blenoxane,硫酸博来霉素,硫酸博莱霉素,NSC125066	DNA/RNA Synthesis; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Bleomycin Sulfate (Blenoxane) 是一种糖肽抗生素，一种 DNA 合成抑制剂。Bleomycin Sulfate 可以引起 DNA 链断裂而不引起 RNA 链断裂。Bleomycin Sulfate 具有抗肿瘤活性。
TN1097	β-Boswellic acid Beta-boswellic acid,β-乳香酸	Lipoxygenase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	β-Boswellic acid (Beta-boswellic acid) 是从乳香的树胶脂中分离出来的一种天然产物。它是 5-脂氧合酶(5-LO) 产物形成的非还原型抑制剂，其直接与 5-LO 相互作用或阻断其易位。具有抗癌、抗肿瘤和抗高血脂活性。
T8130	Ciprofloxacin hydrochloride monohydrate Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,环丙沙星盐酸盐一水合物,Ceprimax,盐酸环丙沙星(一水物),Ciloxan	Antibacterial; Antibiotic	Microbiology/Virology
	Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) 是一种具有高效抗菌活性的氟喹诺酮类抗生素。
T6758	Anisomycin 茴香霉素,Flagecidin,NSC 76712,Wuningmeisu C	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK; Microbiology/Virology
	Anisomycin (Flagecidin) 属于细菌抗生素，是一种蛋白合成抑制剂和一种 JNK 激活剂。Anisomycin 通过抑制肽基转移酶或 80S 核糖体系统来干扰蛋白质和 DNA 的合成。
T0909	Nalidixic acid 萘啶酸,NSC-82174	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Nalidixic acid (NSC-82174) 是一种喹诺酮类抗生素，对革兰氏阳性和革兰氏阴性细菌有效。它在较低浓度下有抑菌作用，而在较高浓度下有杀菌作用。它抑制 DNA 促旋酶和拓扑异构酶 IV 的亚基，并可逆地阻止易感细菌中的 DNA 复制。
T3343	5-methoxyflavone 5-methoxy-2-phenylchromen-4-one,5-甲氧基黄酮	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	5-methoxyflavone (5-methoxy-2-phenylchromen-4-one) 是一种类黄酮，是DNA 聚合酶 β 的抑制剂和 β-淀粉样蛋白毒性的神经保护剂。它通过调控嗜离子 GABAA 受体，起到镇静中枢神经系统的作用。
T40426	Cytidine 5'-diphosphate trisodium salt CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐	Others	Others
	Cytidine 5'-diphosphate trisodium salt (CDP) 可通过尿苷单磷酸激酶 (UMPK) 催化将磷酸基从 ATP 转移到胞苷一磷酸 (CMP) 生成用于合成 DNA 和 RNA 的胞苷三磷酸。
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天然产物

Calf thymus DNA

Cat.No: T13592

Synonym: DNA from calf thymus, Thymonucleic acid

Target: DNA/RNA Synthesis

Cat.No: T21498

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T1068

Synonym: 1,8,9-trihydroxyanthracene,cignoline,蒽林,Anthralin

Target: Others, DNA/RNA Synthesis

1-Hydroxyanthraquinone

Cat.No: T37101

Target: DNA/RNA Synthesis

Deoxycytidine triphosphate

Cat.No: T7520

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite

Neobavaisoflavone

Cat.No: T6S0139

Target: Apoptosis, DNA/RNA Synthesis

Xanthopterin (hydrate)

Cat.No: T13969

Target: Others, DNA/RNA Synthesis

Cat.No: TN2132

Synonym: 1,4-Dihydroxyanthraquinone,1,4-二羟基蒽醌

Target: Others, DNA/RNA Synthesis, Antifungal

Sodium Camptothecin

Cat.No: T40179

Target: DNA/RNA Synthesis

Cat.No: T12651

Synonym: (+)-Rabdosiin

Target: Others

Cat.No: T0064

Synonym: Vitamin B4,腺嘌呤,6-Aminopurine

Target: DNA/RNA Synthesis, Endogenous Metabolite, AChR

Cat.No: TWP2911

Synonym: beta-胸苷,5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T2S1635

Target: MTH1

5-Methylcytosine

Cat.No: T5270

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: TN1134

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Cat.No: T3606

Synonym: 谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza

Target: DNA Methyltransferase

Cat.No: T3717

Synonym: 4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇

Target: DNA Methyltransferase, Virus Protease, Estrogen/progestogen Receptor, Nrf2

3-Hydroxy-2-methylpyridine

Cat.No: T5901

Target: Others

5-Methyl-2'-deoxycytidine

Cat.No: T7457

Synonym: 5-Methyldeoxycytidine,5-甲基-2'-脱氧胞苷,5MedCyd

Target: DNA Methyltransferase, Endogenous Metabolite

Cat.No: T6567

Synonym: Levaquin,Cravit,Tavanic,Fluoroquinolone,左氧氟沙星,(-)-Ofloxacin

Target: Topoisomerase, Antibacterial, Antibiotic

N-Nitrosodiethylamine

Cat.No: T35455

Synonym: Diethylnitrosamine,NDEA

Target: DNA/RNA Synthesis

Adenine hydrochloride

Cat.No: T6225

Synonym: Adenine HCl,腺嘌呤盐酸盐,6-Aminopurine hydrochloride

Target: DNA/RNA Synthesis, Endogenous Metabolite

5-Geranoxy-7-methoxycoumarin

Cat.No: TN3110

Target: Anti-infection, Antibacterial, Antifungal

Chebulinic acid

Cat.No: TQ0184

Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad

Cat.No: T6S0232

Synonym: 圣草酚,Huazhongilexone

Target: Influenza Virus, DNA/RNA Synthesis, Nrf2, Endogenous Metabolite

Cat.No: T1339

Synonym: 阿托胞苷,Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-氮杂胞苷,5-AzaC

Target: Nucleoside Antimetabolite/Analog, DNA Methyltransferase, Antibacterial, Antibiotic, Autophagy

Cat.No: T1508

Synonym: Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA Methyltransferase

Cat.No: T13229

Target: Influenza Virus, Antibacterial, Antibiotic, Antifungal

Cat.No: T3332

Synonym: 异甜菊醇,(-)-Isosteviol

Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase

Novobiocin Sodium

Cat.No: T0974

Synonym: Albamycinsodium,新生霉素钠,Cathomycin,Albamycin

Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy

Cat.No: T1507

Synonym: STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889

Target: DNA Alkylator/Crosslinker, DNA Alkylation, DNA/RNA Synthesis, Antibacterial, Antibiotic, Autophagy

Adenine hemisulfate

Cat.No: T6369

Synonym: 硫酸腺嘌呤,Diadenine sulphate,Adenine sulfate,Adeninsulfat,1H-嘌呤-6-胺硫酸盐

Target: DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T16674

Target: Endogenous Metabolite

Cat.No: T4593

Synonym: 5,8-Dimethoxypsoralen,异茴芹内酯,4,9-Dimethoxypsoralen

Target: Antiviral, DNA/RNA Synthesis, Parasite

Eurycomalactone

Cat.No: TN1637

Target: Anti-infection, NF-κB

Cat.No: T9715

Target: SARS-CoV, DNA/RNA Synthesis

Cat.No: TWS1977

Synonym: 尾叶香茶菜丙素,Kamebakaurine

Target: NF-κB

Dihydromyricetin

Cat.No: T2998

Synonym: Ampelopsin,Ampeloptin,二氢杨梅素

Target: Influenza Virus, GABA Receptor, DNA/RNA Synthesis, mTOR, Autophagy

Cat.No: T6995

Synonym: STA 21,STA21,STA-21

Target: Antibacterial, STAT

Cat.No: T4558

Synonym: 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen

Target: DNA Alkylator/Crosslinker, DHFR

N2-methylguanine

Cat.No: T13791

Synonym: 6-羟基-2-氨甲基嘌呤

Target: DNA/RNA Synthesis, Endogenous Metabolite, Antibacterial

Cat.No: T7004

Synonym: 结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine

Target: Influenza Virus, DNA/RNA Synthesis, Antibacterial, Antibiotic

Eicosapentaenoic Acid

Cat.No: T5368

Target: Histone Demethylase, Others, Endogenous Metabolite

Bleomycin Sulfate

Cat.No: T6116

Synonym: Blenoxane,硫酸博来霉素,硫酸博莱霉素,NSC125066

Target: DNA/RNA Synthesis, Antibiotic

β-Boswellic acid

Cat.No: TN1097

Synonym: Beta-boswellic acid,β-乳香酸

Target: Lipoxygenase, DNA/RNA Synthesis

Ciprofloxacin hydrochloride monohydrate

Cat.No: T8130

Synonym: Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,环丙沙星盐酸盐一水合物,Ceprimax,盐酸环丙沙星(一水物),Ciloxan

Target: Antibacterial, Antibiotic

Cat.No: T6758

Synonym: 茴香霉素,Flagecidin,NSC 76712,Wuningmeisu C

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, JNK

Cat.No: T0909

Synonym: 萘啶酸,NSC-82174

Target: Topoisomerase, Antibacterial, Antibiotic

5-methoxyflavone

Cat.No: T3343

Synonym: 5-methoxy-2-phenylchromen-4-one,5-甲氧基黄酮

Target: DNA/RNA Synthesis

Cytidine 5'-diphosphate trisodium salt

Cat.No: T40426

Synonym: CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐

Target: Others

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00523	DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc) Gp43,DNA-directed DNA polymerase	Escherichia phage RB69	E. coli
	Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction for proofreading purpose. DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.4 kDa and the accession number is Q38087.
TMPJ-00792	DNA PolymeraseBeta Protein, Human, Recombinant (His) DNA Polymeraseβ,POLB,DNA Polymerase Beta,<...	Human	E. coli
	Human DNA polymerase β is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. It conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a proce...
TMPH-00476	DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) DNA-PKcs,DNA-PK catalytic subunit,dna<...	Dictyostelium discoideum	E. coli
	DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) is expressed in E. coli.
TMPH-00611	DNA helicase II Protein, E. coli, Recombinant mutU,DNA 3'-5' helicase II,DNA helicase II...	E. coli	E. coli
	A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA. DNA helicase II Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 82.0 kDa and the acce...
TMPH-00475	DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His) Polydeoxyribonucleotide synthase [NAD(+)],ligA,DNA ...	Desulfotalea psychrophila	E. coli
	DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His) is expressed in E. coli.
TMPH-00427	DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant DNA polymerase IV,dinB,Pol IV	Colwellia psychrerythraea	E. coli
	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant is expressed in E. coli expression syste...
TMPH-00425	DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His) ligA,DNA ligase,Polydeoxyribonucleotide synthase [N...	Colwellia psychrerythraea	E. coli
	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 42.1 kDa and the accession number is Q47YI0.
TMPH-00426	DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) dinB,DNA polymerase IV,Pol IV	Colwellia psychrerythraea	E. coli
	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression...
TMPH-00896	Human adenovirus C serotype 2 DNA-binding protein (His) DNA-binding protein,Early 2A protein,Early E2A ...	HAdV-2	E. coli
	Human adenovirus C serotype 2 DNA-binding protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.8 kDa and the accession number is P03264.
TMPH-00898	Human adenovirus C serotype 5 DNA-binding protein (His) DNA-binding protein,Early 2A protein,DBP,Early E2A ...	HAdV-5	Baculovirus Insect Cells
	Human adenovirus C serotype 5 DNA-binding protein (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 42.3 kDa and the accession number is P03265.
TMPH-00613	DNA polymerase II Protein, E. coli, Recombinant (His & Myc) DNA polymerase II,polB,dinA,Pol II	E. coli	E. coli
	Thought to be involved in DNA repair and/or mutagenesis. Its processivity is enhanced by the beta sliding clamp (dnaN) and clamp loader.
TMPH-03614	DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO) DNA photolyase,Deoxyribodipyrimidine photo-lyase,ph...	Synechococcus	E. coli
	Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 74.3 kDa and the accession number is P05...
TMPH-00360	DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant Exodeoxyribonuclease large subunit,DNA polymerase I...	Cenarchaeum symbiosum	E. coli
	Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 59.0 kDa and the accession number is A0RYM0.
TMPH-00524	ATP-dependent DNA helicase dda Protein, Enterobacteria phage T4, Recombinant (His) ATP-dependent DNA helicase dda,dda,sud	Enterobacteria phage T4	E. coli
	DNA helicase that stimulates viral DNA replication and recombination. Plays a role in T4 DNA replication initiation by selecting and activating DNA origins. Acts by dissociating and reassociating with the DNA molecule being unwound. Unwinds DNA as a monomer in a 5'-to-3' direction at a rate of 250 bp/s and can efficiently displace proteins from the DNA. ATP-dependent DNA helicase dda Protein, Enterobacteria phage T4, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. T...
TMPH-03487	DNA-binding protein H-NS Protein, SerRatia marcescens, Recombinant (His) hnsA,hns,Histone-like protein HLP-II,DNA-binding pr...	Serratia marcescens	E. coli
	A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins. DNA-binding protein H-NS Protein, SerRatia marcescens, Recombinant (His) is expre...
TMPH-00039	Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc) Single-strand DNA-binding protein,63.5 kDa virulenc...	Agrobacterium fabrum	E. coli
	Involved in DNA transformation; mediates the nuclear uptake of single-stranded DNA copies of the transferred DNA (T-DNA) element. Binds single-stranded but not double-stranded DNA regardless of nucleotide sequence composition. Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 70.3 kDa and the accession number is P08062.
TMPH-00616	DNA-binding protein H-NS Protein, E. coli, Recombinant (His) hns,DNA-binding protein H-NS,Protein B1,Protein H1,...	E. coli	E. coli
	A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription. Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. Many of these loci were horizontally transfe...
TMPH-00668	DNA-binding protein HU-alpha Protein, E. coli O157:H7, Recombinant (His & SUMO) HU-2,hupA,DNA-binding protein HU-alpha,NS2	E. coli	E. coli
	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. DNA-binding protein HU-alpha Protein, E. coli O157:H7, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 25.5 kDa and the accession number is P0ACF2.
TMPH-01450	Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His) Phosphoprotein P41,U27,DNA polymerase processivity ...	HHV-6A	P. pastoris (Yeast)
	Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His) is expressed in Yeast.
TMPH-01238	POLQ Protein, Human, Recombinant (His) DNA polymerase eta,POLQ,DNA polymerase the...	Human	Baculovirus Insect Cells
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPH-01241	TOP1 Protein, Human, Recombinant (His & Myc) DNA topoisomerase 1,TOP1,DNA topoisomerase...	Human	Baculovirus Insect Cells
	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates a...
TMPH-01237	POLQ Protein, Human, Recombinant (E. coli, His) DNA polymerase eta,POLQ,DNA polymerase the...	Human	E. coli
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPH-01245	POLM Protein, Human, Recombinant (His & Myc) DNA-directed DNA/RNA polymerase mu,POLM,Te...	Human	Baculovirus Insect Cells
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPH-00583	Rep Protein, E. coli, Recombinant (GST) ATP-dependent DNA helicase Rep,rep,DNA 3'-...	E. coli	E. coli
	Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.
TMPH-00971	RECQL Protein, Human, Recombinant (His) DNA 3'-5' helicase Q1,ATP-dependent DNA he...	Human	Baculovirus Insect Cells
	RECQL Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPH-00972	RECQL Protein, Human, Recombinant RECQL,DNA helicase, RecQ-like type 1,DNA 3...	Human	E. coli
	RECQL Protein, Human, Recombinant is expressed in E. coli.
TMPH-01244	POLM Protein, Human, Recombinant (His) DNA-directed DNA/RNA polymerase mu,Termina...	Human	E. coli
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPH-03611	Sso7d Protein, Sulfolobus solfataricus, Recombinant (His & SUMO) sso7d,Sso7d,DNA-binding protein 7d,7 kDa DNA	Sulfolobus solfataricus	E. coli
	Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature. Stimulates the Holliday junction cleavage activity of Hjc. Sso7d Protein, Sulfolobus solfataricus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.1 kDa and the accession number is P39476.
TMPJ-00872	MGMT Protein, Human, Recombinant (His) MGMT,6-O-methylguanine-DNAmethyltransferase,O-6-met...	Human	E. coli
	MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-met...
TMPH-03656	Vaccinia virus (strain Copenhagen) TopIB Protein (His) Late protein H6,DNA topoisomerase 1B,DNA t...	VACV	E. coli
	Vaccinia virus (strain Copenhagen) TopIB Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40.7 kDa and the accession number is P68697.
TMPJ-00457	OGG1 Protein, Human, Recombinant OGH1,N-Glycosylase/DNA Lyase,DNA-(Apurinic...	Human	E. coli
	Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.
TMPH-01774	OGG1 Protein, Human, Recombinant (His) N-glycosylase/DNA lyase,OGG1	Human	E. coli
	DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. OGG1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 42.8 kDa and the accession number is O15527.
TMPH-03193	Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO) DNA/RNA-binding protein Alba	Pyrococcus furiosus	E. coli
	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes. Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molec...
TMPH-00610	gyrA Protein, E. coli, Recombinant (His) DNA gyrase subunit A,gyrA	E. coli	E. coli
	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli. Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Relaxes negatively supercoiled DNA in an ATP-independent manner. E.coli gyrase has hig...
TMPH-03470	GyrB Protein, Salmonella typhi, Recombinant (His & Myc) gyrB,DNA gyrase subunit B	Salmonella typhi	E. coli
	GyrB Protein, Salmonella typhi, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 51.8 kDa and the accession number is P0A2I4.
TMPJ-00483	DFF45 Protein, Human, Recombinant (His) DNA Fragmentation Factor Subunit Alpha,DFF45,H13,IC...	Human	E. coli
	DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.
TMPH-00665	RecG Protein, E. coli O157:H7, Recombinant (His & SUMO) ATP-dependent DNA helicase RecG,recG	E. coli	E. coli
	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (CsdR) and R-loop formation.
TMPH-02178	TARDBP Protein, Human, Recombinant TAR DNA-binding protein 43,TARDBP	Human	E. coli
	TARDBP Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 44.9 kDa and the accession number is Q13148.
TMPH-00612	MutL Protein, E. coli, Recombinant (His) DNA mismatch repair protein MutL,mutL	E. coli	E. coli
	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA. MutL Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag...
TMPH-02179	TARDBP Protein, Human, Recombinant (His) TAR DNA-binding protein 43,TARDBP	Human	P. pastoris (Yeast)
	TARDBP Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 44.9 kDa and the accession number is Q13148.
TMPY-03601	PDRG1 Protein, Human, Recombinant (His) PDRG,p53 and DNA-damage regulated 1,C20orf126	Human	E. coli
	PDRG1, also known as C2orf126, belongs to the prefoldin subunit beta family. It is predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs. PDRG1 may play a role in chaperone-mediated protein folding. PDRG1 is overexpressed in tumors relative to normal tissues. Its expression is upregulated in multiple malignancies including cancers of the colon, rectum, ovary, lung, stomach, breast and uterus when compared to their respective matched normal tissue...
TMPY-02150	GADD45A Protein, Human, Recombinant (His & GST) GADD45,growth arrest and DNA-damage-inducible, alph...	Human	Baculovirus Insect Cells
	GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulation, DNA repair and genomic stability, apoptosis, and immune responses. The GADD45 Family of genes is rapidly induced by different stressors, including differentiation-inducing cytokines, and there is a large body of evidence that their cognate proteins are key players in cellular ...
TMPH-02026	RPA1 Protein, Human, Recombinant (His & SUMO) Replication factor A protein 1,RPA1,Replication protein A 70...	Human	E. coli
	RPA1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 84.0 kDa and the accession number is P27694.
TMPH-00533	T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc) T7 RNA polymerase,DNA-directed RNA polymerase	Escherichia phage T7	E. coli
	Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short transcripts are synthesized and released before proceeding to the processive transcription of long RNA chains. Unwinds the double-stranded DNA to expose the coding strand for templating. Participates in the initiation of viral DNA replication presumably by making primers accessible...
TMPH-03440	RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) RAD52,DNA repair and recombination protein RAD52	Saccharomyces cerevisiae	E. coli
	Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.1 kDa and the accession number is P06778.
TMPJ-00907	GADD45A Protein, Human, Recombinant (His) GADD45,DDIT1,Growth Arrest and DNA Damage-Inducible...	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some kinases other than PKC. GADD45A can interact with MAPK14, GADD45GIP1, PCNA. In T-cells, GADD45A functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. GADD45A may affect PCNA interaction with some cell division protein kinase complexes, stimulating ...
TMPH-03040	HupB Protein, MenB, Recombinant (His) DNA-binding protein HU-beta,hupB	MenB	E. coli
	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
TMPH-02550	BLM Protein, Mouse, Recombinant (His & Myc) BLM,Bloom syndrome protein,RecQ-like DNA helicase B...	Mouse	E. coli
	BLM Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.7 kDa and the accession number is O88700.
TMPH-03622	PolA Protein, Thermus aquaticus, Recombinant (M747K, His) DNA polymerase I, thermostable,Taq polymerase 1,pol...	Thermus aquaticus	E. coli
	N/A. PolA Protein, Thermus aquaticus, Recombinant (M747K, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 64.9 kDa and the accession number is P19821.
TMPH-00505	RPB1 Protein, Drosophila melanogaster, Recombinant (His) RNA polymerase II subunit A,DNA-directed RNA polyme...	Fruit fly	P. pastoris (Yeast)
	RPB1 Protein, Drosophila melanogaster, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 33.6 kDa and the accession number is P04052.
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重组蛋白

DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc)

Cat.No: TMPH-00523

Species: Escherichia phage RB69

Expression System: E. coli

DNA PolymeraseBeta Protein, Human, Recombinant (His)

Cat.No: TMPJ-00792

Species: Human

Expression System: E. coli

DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc)

Cat.No: TMPH-00476

Species: Dictyostelium discoideum

Expression System: E. coli

DNA helicase II Protein, E. coli, Recombinant

Cat.No: TMPH-00611

Species: E. coli

Expression System: E. coli

DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His)

Cat.No: TMPH-00475

Species: Desulfotalea psychrophila

Expression System: E. coli

DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant

Cat.No: TMPH-00427

Species: Colwellia psychrerythraea

Expression System: E. coli

DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His)

Cat.No: TMPH-00425

Species: Colwellia psychrerythraea

Expression System: E. coli

DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His)

Cat.No: TMPH-00426

Species: Colwellia psychrerythraea

Expression System: E. coli

Human adenovirus C serotype 2 DNA-binding protein (His)

Cat.No: TMPH-00896

Species: HAdV-2

Expression System: E. coli

Human adenovirus C serotype 5 DNA-binding protein (His)

Cat.No: TMPH-00898

Species: HAdV-5

Expression System: Baculovirus Insect Cells

DNA polymerase II Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00613

Species: E. coli

Expression System: E. coli

DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03614

Species: Synechococcus

Expression System: E. coli

DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant

Cat.No: TMPH-00360

Species: Cenarchaeum symbiosum

Expression System: E. coli

ATP-dependent DNA helicase dda Protein, Enterobacteria phage T4, Recombinant (His)

Cat.No: TMPH-00524

Species: Enterobacteria phage T4

Expression System: E. coli

DNA-binding protein H-NS Protein, SerRatia marcescens, Recombinant (His)

Cat.No: TMPH-03487

Species: Serratia marcescens

Expression System: E. coli

Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)

Cat.No: TMPH-00039

Species: Agrobacterium fabrum

Expression System: E. coli

DNA-binding protein H-NS Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00616

Species: E. coli

Expression System: E. coli

DNA-binding protein HU-alpha Protein, E. coli O157:H7, Recombinant (His & SUMO)

Cat.No: TMPH-00668

Species: E. coli

Expression System: E. coli

Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His)

Cat.No: TMPH-01450

Species: HHV-6A

Expression System: P. pastoris (Yeast)

POLQ Protein, Human, Recombinant (His)

Cat.No: TMPH-01238

Species: Human

Expression System: Baculovirus Insect Cells

TOP1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01241

Species: Human

Expression System: Baculovirus Insect Cells

POLQ Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01237

Species: Human

Expression System: E. coli

POLM Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01245

Species: Human

Expression System: Baculovirus Insect Cells

Rep Protein, E. coli, Recombinant (GST)

Cat.No: TMPH-00583

Species: E. coli

Expression System: E. coli

RECQL Protein, Human, Recombinant (His)

Cat.No: TMPH-00971

Species: Human

Expression System: Baculovirus Insect Cells

RECQL Protein, Human, Recombinant

Cat.No: TMPH-00972

Species: Human

Expression System: E. coli

POLM Protein, Human, Recombinant (His)

Cat.No: TMPH-01244

Species: Human

Expression System: E. coli

Sso7d Protein, Sulfolobus solfataricus, Recombinant (His & SUMO)

Cat.No: TMPH-03611

Species: Sulfolobus solfataricus

Expression System: E. coli

MGMT Protein, Human, Recombinant (His)

Cat.No: TMPJ-00872

Species: Human

Expression System: E. coli

Vaccinia virus (strain Copenhagen) TopIB Protein (His)

Cat.No: TMPH-03656

Species: VACV

Expression System: E. coli

OGG1 Protein, Human, Recombinant

Cat.No: TMPJ-00457

Species: Human

Expression System: E. coli

OGG1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01774

Species: Human

Expression System: E. coli

Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO)

Cat.No: TMPH-03193

Species: Pyrococcus furiosus

Expression System: E. coli

gyrA Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00610

Species: E. coli

Expression System: E. coli

GyrB Protein, Salmonella typhi, Recombinant (His & Myc)

Cat.No: TMPH-03470

Species: Salmonella typhi

Expression System: E. coli

DFF45 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00483

Species: Human

Expression System: E. coli

RecG Protein, E. coli O157:H7, Recombinant (His & SUMO)

Cat.No: TMPH-00665

Species: E. coli

Expression System: E. coli

TARDBP Protein, Human, Recombinant

Cat.No: TMPH-02178

Species: Human

Expression System: E. coli

MutL Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00612

Species: E. coli

Expression System: E. coli

TARDBP Protein, Human, Recombinant (His)

Cat.No: TMPH-02179

Species: Human

Expression System: P. pastoris (Yeast)

PDRG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03601

Species: Human

Expression System: E. coli

GADD45A Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02150

Species: Human

Expression System: Baculovirus Insect Cells

RPA1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02026

Species: Human

Expression System: E. coli

T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)

Cat.No: TMPH-00533

Species: Escherichia phage T7

Expression System: E. coli

RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO)

Cat.No: TMPH-03440

Species: Saccharomyces cerevisiae

Expression System: E. coli

GADD45A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00907

Species: Human

Expression System: E. coli

HupB Protein, MenB, Recombinant (His)

Cat.No: TMPH-03040

Species: MenB

Expression System: E. coli

BLM Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02550

Species: Mouse

Expression System: E. coli

PolA Protein, Thermus aquaticus, Recombinant (M747K, His)

Cat.No: TMPH-03622

Species: Thermus aquaticus

Expression System: E. coli

RPB1 Protein, Drosophila melanogaster, Recombinant (His)

Cat.No: TMPH-00505

Species: Fruit fly

Expression System: P. pastoris (Yeast)

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Cat. No.	Product Name	Target	Signaling Pathways
T11067	VX-984 M9831	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。
T19203	Bendamustine D4 SDX-105 D4	Others	Others
	Bendamustine D4 is the deuterium-labeled Bendamustine. Bendamustine is a DNA cross-linking compound with alkylating and antimetabolite properties. Bendamustine causes DNA breaks.
TMIH-0091	AOH-d3
	AOH-d3 是 AOH 的氘代化合物。AOH 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体，靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用，导致 DNA 复制应激，诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用，可抑制肿瘤细胞生长。
TMIH-0025	13C-d3-AOH1996
	13C-d3-AOH1996 是 AOH1996 的 13C 和氘代化合物。AOH1996 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体，靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用，导致 DNA 复制应激，诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用，可抑制肿瘤细胞生长。
TMID-0076	Busulfan-d8
	Busulfan-d8 是 Busulfan 的氘代化合物。Busulfan 的 CAS 号为 55-98-1。Busulfan 是二甲磺酸盐的合成衍生物，具有抗肿瘤和细胞毒特性。是一种烷化剂，对骨髓具有选择性免疫抑制作用。
TMID-0078	Irinotecan-d10 Hydrochloride
	Irinotecan-d10 Hydrochloride 是 Irinotecan Hydrochloride 的氘代化合物。Irinotecan Hydrochloride 的 CAS 号为 100286-90-6。Irinotecan Hydrochloride 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。
TMID-0194	Ofloxacin-d8
	Ofloxacin-d8 是 Ofloxacin 的氘代化合物。Ofloxacin 的 CAS 号为 82419-36-1。Ofloxacin是可抑制细菌DNA旋转酶的一种氟喹诺酮类抗生素。
T33410	MitoNeoD Mito Neo D,Mito-Neo-D,Mito Neo-D,Mito-NeoD
	MitoNeoD is a novel mitochondria-targeted O2(⋅−) probe that can be used in vivo. It prevents DNA intercalation. MitoNeoD incorporates a carbon-deuterium bond, and enhances O2(⋅−) selectivity.
T36895	5-Fluorouracil-13C,15N2 5-Fluorouracil-13C,15N2
	5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.
T19201	Banoxantrone-d12 dihydrochloride AQ4N D12 dihydrochloride	Others	Others
	Banoxantrone D12 (AQ4N D12) dihydrochloride is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.
T71401	Oxaliplatin-d10
	Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2....
T12648	(R)-VX-984 (R)-M9831	Others	Others
	(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.
T36021	Flumequine-13C3 Flumequine-13C3
	Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl...
T10458	Banoxantrone (D12) Banoxantrone D12,AQ4N D12	Others	Others
	Banoxantrone D12 (AQ4N D12) is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.
TMID-0227	Rifabutin-d7
	Rifabutin-d7 是 Rifabutin 的氘代化合物。Rifabutin 的 CAS 号为 72559-06-9。Rifabutin是半合成的安莎霉素抗生素，抑制 DNA 依赖性 RNA 聚合酶，有抗分枝杆菌作用。
TMID-0166	Thymine-d4
	Thymine-d4 是 Thymine 的氘代化合物。Thymine 的 CAS 号为 65-71-4。Thymine 是 DNA 的四个碱基之一，在动物癌症模型中，能够作为5-氟尿嘧啶的靶标，其 Km=2.3 μM。
TMID-0065	Adenine-2-d1
	Adenine-2-d1 是 Adenine 的氘代化合物。Adenine 的 CAS 号为 73-24-5。Adenine 是一种嘌呤衍生物，是一种核碱基。它在细胞呼吸、以富含能量的 ATP 和 NAD 和 FAD 的形式和蛋白质合成作用，作为 DNA 和 RNA 的化学成分。
TMID-0192	Procainamide-d10
	Procainamide-d10 是 Procainamide 的氘代化合物。Procainamide 的 CAS 号为 51-06-9。Procainamide 是一种特异性强效的 DNA 甲基转移酶 1 (DNMT1) 抑制剂。普鲁卡因胺是一种 1A 类抗心律失常药物。Procainamide 具有研究癌症和心律失常的潜力。
TMIJ-0404	Dibenz[a,h]anthracene-d14
	Dibenz[a,h]anthracene-d14 是 Dibenz[a,h]anthracene 的氘代化合物。Dibenz[a,h]anthracene 的 CAS 号为 53-70-3。Dibenz[a,h]anthracene诱导细菌DNA损伤和基因突变，并在几种哺乳动物细胞培养物中诱导基因突变和转化。
TMIH-0154	Ciprofloxacin-d8
	Ciprofloxacin-d8 是 Ciprofloxacin 的氘代化合物。Ciprofloxacin 的 CAS 号为 85721-33-1。Ciprofloxacin是一种有高抗菌活性的氟喹诺酮类抗生素。
TMID-0286	Rifaximin-d6
	Rifaximin-d6 是 Rifaximin 的氘代化合物。Rifaximin 的 CAS 号为 80621-81-4。Rifaximin是一种胃肠道选择性抗生素，与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合，抑制细菌 RNA 合成。与革兰氏阴性菌（MIC：8-50 毫克/毫升）相比，它对革兰氏阳性菌株（MIC：0.03-5 毫克/毫升）的敏感性更高。
TMID-0085	Carboplatin-d4
	Carboplatin-d4 是 Carboplatin 的氘代化合物。Carboplatin 的 CAS 号为 41575-94-4。Carboplatin 是一种具有抗肿瘤活性的顺铂衍生物。它是一种DNA 合成抑制剂，可与 DNA 结合，抑制复制和转录并诱导细胞死亡。
TMID-0195	Levofloxacin-d8
	Levofloxacin-d8 是 Levofloxacin 的氘代化合物。Levofloxacin 的 CAS 号为 100986-85-4。Levofloxacin是合成的氟喹诺酮类抗生素，有抑制细菌DNA旋转酶的超螺旋活性的作用，能阻止DNA复制。
TMIH-0300	Levofloxacin-d3
	Levofloxacin-d3 是 Levofloxacin 的氘代化合物。Levofloxacin 的 CAS 号为 100986-85-4。Levofloxacin是合成的氟喹诺酮类抗生素，有抑制细菌DNA旋转酶的超螺旋活性的作用，能阻止DNA复制。
TMIH-0368	Naringenin-d4
	Naringenin-d4 是 Naringenin 的氘代化合物。Naringenin 的 CAS 号为 480-41-1。Naringenin是葡萄柚中主要的黄烷酮，可作为抗氧化剂、自由基清除剂、抗炎剂、碳水化合物代谢促进剂、免疫系统调节剂。
TMIJ-0402	N-Nitrosodiethylamine-d10
	N-Nitrosodiethylamine-d10 是 N-Nitrosodiethylamine 的氘代化合物。N-Nitrosodiethylamine 的 CAS 号为 55-18-5。N-Nitrosodiethylamine 是致癌物质二烷基硝胺。它主要存在于水、烟草烟雾、腌制食品、油炸食品以及许多酒精饮料中。它与DNA修复/复制相关的核酶的变化相关。
T71984	Enrofloxacin-d5
	Enrofloxacin-d5 is intended for use as an internal standard for the quantification of enrofloxacin by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic. It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml). Enrofloxacin inhibits bacterial DNA gyrase. In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model...
TMIH-0457	Proguanil-d6 HCl
	Proguanil-d6 HCl 是 Proguanil HCl 的氘代化合物。Proguanil HCl 的 CAS 号为 637-32-1。Proguanil hydrochloride 是一种双胍类抗疟疾剂，在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。
TMIJ-0375	Levomefolic Acid-13C-d3
	Levomefolic Acid-13C-d3 是 Levomefolic Acid 的 13C 和氘代化合物。Levomefolic Acid 的 CAS 号为 31690-09-2。Levomefolic acid是一种具有口服活性、可穿过血脑屏障的天然活性叶酸，是广泛使用的叶酸食品补充剂。
TMIJ-0204	Betamethasone-d10 Dipropionate
	Betamethasone-d10 Dipropionate 是 Betamethasone Dipropionate 的氘代化合物。Betamethasone Dipropionate 的 CAS 号为 5593-20-4。Betamethasone dipropionate 是糖皮质激素类固醇，具有免疫抑制、抗炎作用。
T35778	Ochratoxin A-13C20 Ochratoxin A-13C20
	Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.2Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1phase, and apoptosis in mouse ...
TMID-0079	Norfloxacin-d8
	Norfloxacin-d8 是 Norfloxacin 的氘代化合物。Norfloxacin 的 CAS 号为 70458-96-7。Norfloxacin是广谱抗生素，能通过结合DNA旋转酶抑制革兰氏阳性和阴性菌。
TMID-0242	Capecitabine-d11
	Capecitabine-d11 是 Capecitabine 的氘代化合物。Capecitabine 的 CAS 号为 154361-50-9。Capecitabine 是一种可口服的前药，可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil。
T35775	HT-2 Toxin-13C22 HT-2 Toxin-13C22
	HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...
TMID-0266	Stavudine-α,α,α,6-d4
	Stavudine-α,α,α,6-d4 是 Stavudine 的氘代化合物。Stavudine 的 CAS 号为 3056-17-5。Stavudine 是一种口服活性核苷逆转录酶抑制剂，还抑制线粒体 DNA 的复制，具有抗HIV-1和HIV-2的活性。它降低 NLRP3 炎症小体激活，调节淀粉样 β 自噬，诱导细胞凋亡。
TMIJ-0288	Danofloxacin-d3
	Danofloxacin-d3 是 Danofloxacin 的氘代化合物。Danofloxacin 的 CAS 号为 112398-08-0。Danofloxacin free base 是一种具有口服活性第三代氟喹诺酮抗菌剂，对大多数革兰氏阴性和革兰氏阳性细菌，支原体和衣原体物种具有广谱的活性，并通过抑制细菌的 DNA 回转酶发挥抗菌作用。它可用于牛，猪和鸡呼吸道疾病的研究。
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...
TMID-0006	Budesonide-d8 mixture of diastereomers-d8
	Budesonide-d8 是 Budesonide 的氘代化合物。Budesonide 的 CAS 号为 51333-22-3。Budesonide 是吸入型糖皮质类固醇，是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积，逆转 DNA 低度甲基化，调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。

同位素标记化合物

Cat.No: T11067

Synonym: M9831

Target: DNA-PK

Bendamustine D4

Cat.No: T19203

Synonym: SDX-105 D4

Target: Others

Cat.No: TMIH-0091

Cat.No: TMIH-0025

Cat.No: TMID-0076

Irinotecan-d10 Hydrochloride

Cat.No: TMID-0078

Cat.No: TMID-0194

Cat.No: T33410

Synonym: Mito Neo D,Mito-Neo-D,Mito Neo-D,Mito-NeoD

5-Fluorouracil-13C,15N2

Cat.No: T36895

Synonym: 5-Fluorouracil-13C,15N2

Banoxantrone-d12 dihydrochloride

Cat.No: T19201

Synonym: AQ4N D12 dihydrochloride

Target: Others

Oxaliplatin-d10

Cat.No: T71401

Cat.No: T12648

Synonym: (R)-M9831

Target: Others

Flumequine-13C3

Cat.No: T36021

Synonym: Flumequine-13C3

Banoxantrone (D12)

Cat.No: T10458

Synonym: Banoxantrone D12,AQ4N D12

Target: Others

Cat.No: TMID-0227

Cat.No: TMID-0166

Cat.No: TMID-0065

Procainamide-d10

Cat.No: TMID-0192

Dibenz[a,h]anthracene-d14

Cat.No: TMIJ-0404

Ciprofloxacin-d8

Cat.No: TMIH-0154

Cat.No: TMID-0286

Cat.No: TMID-0085

Levofloxacin-d8

Cat.No: TMID-0195

Levofloxacin-d3

Cat.No: TMIH-0300

Cat.No: TMIH-0368

N-Nitrosodiethylamine-d10

Cat.No: TMIJ-0402

Enrofloxacin-d5

Cat.No: T71984

Proguanil-d6 HCl

Cat.No: TMIH-0457

Levomefolic Acid-13C-d3

Cat.No: TMIJ-0375

Betamethasone-d10 Dipropionate

Cat.No: TMIJ-0204

Ochratoxin A-13C20

Cat.No: T35778

Synonym: Ochratoxin A-13C20

Cat.No: TMID-0079

Capecitabine-d11

Cat.No: TMID-0242

HT-2 Toxin-13C22

Cat.No: T35775

Synonym: HT-2 Toxin-13C22

Stavudine-α,α,α,6-d4

Cat.No: TMID-0266

Danofloxacin-d3

Cat.No: TMIJ-0288

Cat.No: T38297

Synonym: Ribavirin-13C5

Cat.No: TMID-0006

Synonym: mixture of diastereomers-d8

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