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TargetMol | Compound Library

药物功能重定位化合物库现货

Drug Repurposing Compound Library

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产品编号 L9200

传统的药物开发涉及从头确认和验证新分子实体,这是一个耗时且成本高昂的过程,随着对药物安全性及有效性的要求不断提高,开发新药的成本还将持续上涨。由于时间和成本大幅降低,近年来药物功能重定位受到越来越多关注,高内涵筛选、新的生物标志物发现和生物信息学的快速发展为基于靶点或细胞的药物重定位创造了机会。 TargetMol 药物功能重定位化合物库收集了4921 种已上市和进入临床期的药物,这些化合物经过大量的临床前研究实验,具有活性高、毒性低和机制明确的特点,适用于药物筛选的同时,也是细胞诱导分化的有力工具。

TargetMol 的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。

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产品编号 L9200

药物功能重定位化合物库

规格

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
询价 & 定制

产品描述 产品描述

  • 4921种全球上市药物和临床药物的独特集合,可用于高通量筛选和高内涵筛选,是老药新用、新的药物靶点筛选和细胞诱导的有效工具。
  • 是整个行业规模领先的药物功能重定位化合物库;
  • 所有上市化合物得到FDA、EMA、NMPA等权威部门审批或收录在USP、EP、BP、JP、CP等药典文献中;
  • 涵盖多个研究领域:肿瘤、心血管药物、抗炎/免疫、神经系统药物、呼吸系统药物等;
  • 靶点多样,包括5-HT Receptor、Sodium Channel、p38 MAPK、PI3K、MEK等;
  • 详细的说明书,化合物结构、靶点信息、适应症信息、活性描述等;
  • 结构多样,药效显著,可渗透细胞;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

Packaging And Storage | TargetMol 包装和储存

  • 可选用DMSO耐受的96/384孔板或2D 条形码编码管;
  • 干粉蓝冰运输,DMSO溶液干冰运输;
  • 排布:96孔板:1st & 12th 空白对照,384孔板:1st & 2nd & 23th & 24th空白对照。

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Library Customization | TargetMol 化合物库组成

Autophagy
Antibacterial
Apoptosis
Antibiotic
Endogenous Metabolite
5-HT Receptor
Adrenergic Receptor
AChR
Dopamine Receptor
Histamine Receptor
COX
HIV Protease
Parasite
DNA/RNA Synthesis
Antifungal
Sodium Channel
Potassium Channel
Calcium Channel
VEGFR
EGFR
Topoisomerase
PDE
PI3K
Glucocorticoid Receptor
Reactive Oxygen Species
SARS-CoV
P450
CDK
Estrogen/progestogen Receptor
HCV Protease
Influenza Virus
FLT
Ferroptosis
GABA Receptor
Dehydrogenase
PPAR
NF-κB
JAK
Microtubule Associated
PDGFR
c-Kit
HDAC
FGFR
RAAS
Estrogen Receptor/ERR
c-Met/HGFR
Prostaglandin Receptor
Mitophagy
mTOR
HBV
Nucleoside Antimetabolite/Analog
Androgen Receptor
Src
Adenosine Receptor
Reverse Transcriptase
Tyrosine Kinases
Serotonin Transporter
iGluR
Bcr-Abl
NMDAR
GPR
HSV
Norepinephrine
AChE
Proteasome
TRP/TRPV Channel
GluR
MAO
Raf
BTK
HER
ATPase
ADC Cytotoxin
Virus Protease
ribosome
TNF
Phosphatase
Antiviral
Progesterone Receptor
PARP
Opioid Receptor
Epigenetic Reader Domain
HSP
ROS
Akt
Carbonic Anhydrase
Transferase
p38 MAPK
Antioxidant
Beta Amyloid
PKC
IL Receptor
Aurora Kinase
ALK
HIF/HIF Prolyl-Hydroxylase
Proton pump
Antifection
P-gp
MEK
MMP
Monoamine Oxidase
Thyroid hormone receptor(THR)
Histone Methyltransferase
DNA Alkylator/Crosslinker
Drug Metabolite
Mitochondrial Metabolism
DPP-4
CCR
Endothelin Receptor
TLR
c-RET
Thrombin
Interleukin
AMPK
ERK
Trk receptor
Phospholipase
GSK-3
CXCR
Retinoid Receptor
c-Fms
GNRH Receptor
MRP
Caspase
P2X Receptor
BCL
Lipoxygenase
SGLT
STAT
HMG-CoA Reductase
TAM Receptor
S1P Receptor
Integrin
Factor Xa
PKA
ROCK
Gamma-secretase
Chk
Neurokinin receptor
FAK
p53
NO Synthase
DNA-PK
NADPH
E1/E2/E3 Enzyme
Guanylate cyclase
DNA Alkylation
Vasopressin Receptor
HIF
Cannabinoid Receptor
Syk
CFTR
LPL Receptor
Reductase
Wnt/beta-catenin
DNA gyrase
TGF-beta/Smad
Kras
DHFR
Amino Acids and Derivatives
Glutathione Peroxidase
Antifolate
Serine Protease
FXR
Hedgehog/Smoothened
IGF-1R
Nrf2
RSV
ROS Kinase
P2Y Receptor
Histone Demethylase
CSF-1R
IAP
ATM/ATR
Hydroxylase
PLK
Sigma receptor
Tyrosinase
Mdm2
Chloride channel
NOS
CETP
ABC
Glucosidase
CaMK
Indoleamine 2,3-Dioxygenase (IDO)
DNA Methyltransferase
S6 Kinase
Kinesin
CAT
BACE
Cysteine Protease
Leukotriene Receptor
Vitamin
Smo
OX Receptor
Xanthine Oxidase
Sirtuin
Ligand for E3 Ligase
cholecystokinin
JNK
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RIP kinase
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Monoamine Transporter
DNA
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Casein Kinase
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NOD
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Pim
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Isocitrate Dehydrogenase (IDH)
Fatty Acid Synthase
PAK
Bradykinin Receptor
IκB/IKK
GHSR
IRAK
AhR
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IFNAR
Cell wall
Tie-2
Serine/threonin kinase
IDO
MT Receptor
FAAH
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MAPK
GPCR19
Ephrin Receptor
CRFR
Melanocortin Receptor
CGRP Receptor
Complement System
Gap Junction Protein
NADPH-oxidase
Imidazoline Receptor
CRM1
DprE1
YAP
Melatonin Receptor
CaSR
Liver X Receptor
Annexin A
UGT
Neuropeptide Y Receptor
Somatostatin
KSP
Lipid
Wee1
OAT
STING
Decarboxylase
Neprilysin
GST
Acetyl-CoA Carboxylase
LPA Receptor
PDK
Oxytocin Receptor
Anti-infection
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Protease-activated Receptor
NOD-like Receptor (NLR)
PD-1/PD-L1
PROTACs
Monocarboxylate transporter
Arginase
PERK
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PYK2
NAMPT
Glutaminase
Myosin
LDL
Na-K-Cl cotransporter
Hexokinase
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Mucin
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Telomerase
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transporter
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advanced glycation end products
Taste receptor
GSNOR
NEDD8
Ligands for Target Protein for PROTAC
Lipase
TOPK
VDA
Galectin
c-Myc
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IRE1
FLAP
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Integrase
HCN Channel
Stearoyl-CoA Desaturase (SCD)
Thrombopoietin Receptor
ATP Citrate Lyase
BCRP
Glutathione reductase
Porcupine
CD73
GluCls
PAI-1
Pyroptosis
Aquaporin
Discoidin Domain Receptor (DDR)
p97
MLK
PKM
Apelin receptor
Adenylyl cyclase
NPC1L1
Hydrogenase
MALT
Dynamin
Na+/Ca2+ Exchanger
Arrestin
RAR/RXR 
DYRK
gp120/CD4
GTPase
N-Acetylglucosaminyltransferase
VDAC
Hck
LIM Kinase
Neurotensin Receptor
Stemness kinase
Immunology/Inflammation related
SIK
Adiponectin receptor
PAFR
MTH1
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GRK
AAK1 (AP2 associated kinase 1)
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PROTAC Linker
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ASK
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SGK
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BMI-1