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DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
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DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,930 | 6-8周 | |
5 mg | ¥ 3,320 | 6-8周 | |
25 mg | ¥ 10,600 | 6-8周 | |
50 mg | ¥ 13,800 | 6-8周 | |
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM). |
靶点活性 | DNMT1:0.91 μM (kd), DNMT1:1.7 μM |
体外活性 | DC_517 (0, 0.75, 1.5, and 3 μM) also dose-dependently induces apoptotic cell death in HCT116 cells. DC_517 (1.25, 2.5, 5, and 10 μM) effectively inhibits Capan-1 (human pancreatic adenocarcinoma cells) and the proliferation of HCT116 (human colon cancer) after treatment for 24, 48, and 72 h. |
分子量 | 505.65 |
分子式 | C33H35N3O2 |
CAS No. | 500017-70-9 |
密度 | 1.20 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (98.88 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
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