- 全部删除
- 您的购物车当前为空
PARP1-IN-27 (Compound 9B),作为PARP1和PARP2的有效抑制剂,在SUM149PT细胞中的IC50分别达到2.53 nM和6.45 nM。此外,PARP1-IN-27对BRCA突变癌细胞系SUM149PT、HCC1937和Capan-1的增殖抑制效果显著,相应的IC50值为0.62、1.91和4.26 μM。该化合物能够加剧DNA双链断裂,促进ROS生成,并在G2/M期阻滞细胞周期,最终在SUM149PT细胞中触发细胞凋亡(apoptosis)。
PARP1-IN-27 (Compound 9B),作为PARP1和PARP2的有效抑制剂,在SUM149PT细胞中的IC50分别达到2.53 nM和6.45 nM。此外,PARP1-IN-27对BRCA突变癌细胞系SUM149PT、HCC1937和Capan-1的增殖抑制效果显著,相应的IC50值为0.62、1.91和4.26 μM。该化合物能够加剧DNA双链断裂,促进ROS生成,并在G2/M期阻滞细胞周期,最终在SUM149PT细胞中触发细胞凋亡(apoptosis)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 待询 | 待询 | |
50 mg | 待询 | 待询 |
产品描述 | PARP1-IN-27 (Compound 9B) serves as an inhibitor of both PARP1 and PARP2, exhibiting IC 50 values of 2.53 nM and 6.45 nM, respectively, in SUM149PT cells. This compound effectively suppresses the proliferation of BRCA-mutated cancer cell lines such as SUM149PT, HCC1937, and Capan-1, with respective IC 50 values of 0.62, 1.91, and 4.26 μM. Additionally, PARP1-IN-27 exacerbates DNA double-strand breaks, enhances ROS production, causes G2/M phase cell cycle arrest, and triggers apoptosis in SUM149PT cells. |
分子量 | 313.28 |
分子式 | C17H12FNO4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
评论内容