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ML-60218 是广谱 RNA pol III 抑制剂,对酿酒酵母和人类的 IC50 分别为 32 和 27 μM。 ML-60218 会破坏已组装的病毒质并阻碍新病毒质的形成。
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ML-60218 是广谱 RNA pol III 抑制剂,对酿酒酵母和人类的 IC50 分别为 32 和 27 μM。 ML-60218 会破坏已组装的病毒质并阻碍新病毒质的形成。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 497 | 现货 | |
2 mg | ¥ 729 | 现货 | |
5 mg | ¥ 1,230 | 现货 | |
10 mg | ¥ 1,980 | 现货 | |
25 mg | ¥ 3,370 | 现货 | |
50 mg | ¥ 4,890 | 现货 | |
100 mg | ¥ 6,860 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,330 | 现货 |
产品描述 | ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms. |
体外活性 | ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest. The combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis[1]. ML-60218 interferes with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage[2]. |
分子量 | 452.38 |
分子式 | C19H15Cl2N3O2S2 |
CAS No. | 577784-91-9 |
Smiles | Cc1c(sc2ccc(Cl)cc12)-c1cc(NS(=O)(=O)c2ccccc2Cl)n(C)n1 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 95 mg/mL (210.00 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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