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QKY-613 是一种通过靶向核酸修饰途径以提升免疫监视能力的前药。其作用机制为促进6mdA (N6-甲基脱氧腺苷) 在病毒 DNA 中的选择性掺入,增强 DNA 的相分离能力,从而提高 cGAS 的激活,强化宿主免疫监视。在病毒感染的小鼠模型中,它显著降低了老年小鼠的死亡率。QKY-613 有望用于研究基于核酸修饰的免疫监视机制。
QKY-613 是一种通过靶向核酸修饰途径以提升免疫监视能力的前药。其作用机制为促进6mdA (N6-甲基脱氧腺苷) 在病毒 DNA 中的选择性掺入,增强 DNA 的相分离能力,从而提高 cGAS 的激活,强化宿主免疫监视。在病毒感染的小鼠模型中,它显著降低了老年小鼠的死亡率。QKY-613 有望用于研究基于核酸修饰的免疫监视机制。
产品描述 | QKY-613 is a prodrug designed to enhance immune surveillance by targeting nucleic acid modification pathways. It selectively facilitates the incorporation of 6mdA (N6-methyl-deoxyadenosine) into viral DNA, boosting the DNA's phase separation potential and subsequently increasing cGAS activation levels to strengthen host immune surveillance. In mouse models of viral infection, QKY-613 significantly reduced mortality in aged mice. This compound holds promise for studying immune surveillance mechanisms based on nucleic acid modifications. |
分子量 | 582.55 |
分子式 | C27H31N6O7P |
CAS No. | 2484713-92-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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