PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC 50 of 36 μM. PIP-199 can be used for the study of the mechanisms underlying DNA crosslink repair and could serve as sensitizing chemoresistant tumors [1].

MM2 is a peptide which is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM) [1]. Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies [1]. Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents [1].