Aldoxorubicin

产品编号 T11090LCas号 1361644-26-9

别名 DOXO-EMCH|||INNO-206

Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).

Aldoxorubicin

产品编号 T11090L别名 DOXO-EMCH, INNO-206Cas号 1361644-26-9

Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).

规格	价格	库存	数量
100 mg	¥ 9,820	5日内发货

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产品介绍

生物活性

产品描述	Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).
体外活性	Aldoxorubicin (0.27 to 2.16 μM) suppresses blood vessel formation. Aldoxorubicin (0.27 to 2.16 μM) also reduces multiple myeloma cell growth in a pH-dependent fashion.
体内活性	Aldoxorubicin displays a good safety profile at doses up to 260 mg/mL doxorubicin equivalents and is able to cause tumor regressions in breast cancer, small cell lung cancer, and sarcoma in phase I study[2]. In a murine renal cell carcinoma model and in breast carcinoma xenograft models, Aldoxorubicin also shows superior activity over doxorubicin [3]. On days 28, Aldoxorubicin (10.8 mg/kg, i.v.) displays obviously smaller tumor volumes and IgG levels, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor[1].
别名	DOXO-EMCH, INNO-206

化学信息

分子量	750.75
分子式	C₃₇H₄₂N₄O₁₃
CAS No.	1361644-26-9

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 75 mg/mL (99.90 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3320 mL	6.6600 mL	13.3200 mL	66.6001 mL
5 mM	0.2664 mL	1.3320 mL	2.6640 mL	13.3200 mL
10 mM	0.1332 mL	0.6660 mL	1.3320 mL	6.6600 mL
20 mM	0.0666 mL	0.3330 mL	0.6660 mL	3.3300 mL
50 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3320 mL