SJG-136

Name: SJG-136
Brand: TargetMol
SKU: T16890
Rating: 4.5 (1 reviews)

还可以

产品编号 T16890Cas号 232931-57-6

别名 NSC-694501

SJG-136 is a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA).

还可以

产品编号 T16890 别名 NSC-694501Cas号 232931-57-6

SJG-136 is a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA).

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产品介绍

生物活性

产品描述	SJG-136 is a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA).
靶点活性	pBR322 DNA:（XL50）45 nM
体外活性	SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC50: 22.5 pM), A2780cisR (IC50: 24 pM), CH1 (IC50: 0.12 nM), CH1cisR (IC50: 0.6 nM), and SKOV-3 (IC50: 9.1 nM). SJG-136 also reduces the viability of a panel of canine cancer cells (GI50: ranging from 0.33 - >100 nM after a 1 h exposure, and <0.03 - 17.33 nM following continuous exposure) [1][2].
体内活性	SJG-136-induced H2AX phosphorylation shows good correspondence, but less sensitivity, than measurement of foci. SJG-136 displays a more potent antitumor effect against CMeC-1 tumor at 0.30 mg/kg than 0.15 mg/kg either as a single dose or administered once a week for three weeks via dosed intravenously in mice [2].
别名	NSC-694501

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (179.66 mM), Sonication is recommended.

溶液配制表

DMSO