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UNC-2170 (UNC2170 Maleate) 是53BP1(IC50=29 µM;Kd=22 µM) 选择性的、功能活性的片段状配体,对 53BP1 的选择性比其他九种甲基赖氨酸读取器蛋白质高出至少17倍。53BP1 是 Kme 结合蛋白,在 DNA 损伤修复途径中起核心作用,并被招募到双链断裂位点。
UNC-2170 (UNC2170 Maleate) 是53BP1(IC50=29 µM;Kd=22 µM) 选择性的、功能活性的片段状配体,对 53BP1 的选择性比其他九种甲基赖氨酸读取器蛋白质高出至少17倍。53BP1 是 Kme 结合蛋白,在 DNA 损伤修复途径中起核心作用,并被招募到双链断裂位点。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 296 | 现货 | |
2 mg | ¥ 428 | 现货 | |
5 mg | ¥ 696 | 现货 | |
10 mg | ¥ 1,120 | 现货 | |
25 mg | ¥ 1,910 | 现货 | |
50 mg | ¥ 2,800 | 现货 | |
100 mg | ¥ 3,990 | 现货 | |
200 mg | ¥ 5,380 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 750 | 现货 |
产品描述 | UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand. |
体外活性 | UNC-2170 (500 μM) results in a significant increase in soluble 53BP1 as compared to lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 μM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells[1]. |
别名 | UNC-2170, UNC2170, UNC 2170 |
分子量 | 313.23 |
分子式 | C14H21BrN2O |
CAS No. | 1648707-58-7 |
Smiles | CC(C)(C)NCCCNC(=O)c1cccc(Br)c1 |
密度 | 1.233 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 60 mg/ml (191.55 mM), Sonication is recommended. Methanol: 125 mg/mL (399.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO/Methanol
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