cGAMP

Name: cGAMP
Brand: TargetMol
SKU: T13606
Price: 262 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T13606Cas号 849214-04-6

别名 Cyclic GMP-AMP, 3',3'-cGAMP

cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.

还可以

产品编号 T13606 别名 Cyclic GMP-AMP, 3',3'-cGAMPCas号 849214-04-6

cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.

规格	价格	库存	数量
25 mg	¥ 10,600	期货

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产品介绍

生物活性

产品描述	cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.
体外活性	cGAMP directly activates murine and human dendritic cells in vitro. cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice [2]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding IL-1, IL-6, or TNF [3]. cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs [4].
体内活性	cGAMP stimulates the antigen-specific cytokine production by spleen cells of immunized mice [2].
别名	Cyclic GMP-AMP, 3',3'-cGAMP

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 20 mg/mL (29.66 mM), Sonication is recommended.

溶液配制表

H2O