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cGAMP
产品编号 T13606Cas号 849214-04-6
别名 Cyclic GMP-AMP, 3',3'-cGAMP
cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.
cGAMP
产品编号 T13606 别名 Cyclic GMP-AMP, 3',3'-cGAMPCas号 849214-04-6
cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 10,600 | 期货 |
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产品介绍
生物活性
化学信息
| 产品描述 | cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand. |
| 体外活性 | cGAMP directly activates murine and human dendritic cells in vitro. cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice [2]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding IL-1, IL-6, or TNF [3]. cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs [4]. |
| 体内活性 | cGAMP stimulates the antigen-specific cytokine production by spleen cells of immunized mice [2]. |
| 别名 | Cyclic GMP-AMP, 3',3'-cGAMP |
| 分子量 | 674.41 |
| 分子式 | C20H24N10O13P2 |
| CAS No. | 849214-04-6 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| 溶解度信息 | H2O: 20 mg/mL (29.66 mM), Sonication is recommended. | |||||||||||||||||||||||||
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体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
剂量转换
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