875
104
4
23
19
Cat. No. | Product Name | ||
---|---|---|---|
L9850 | 口服活性化合物库 | 2427 compounds | |
2427 种口服活性化合物独特集合,可用于高通量筛选和高内涵筛选 | |||
L9610 | 环肽库 | 80 compounds | |
80 种环肽分子,可用于高通量和高内涵筛选; | |||
L2170 | 肿瘤免疫治疗小分子化合物库 | 449 compounds | |
449 种靶向肿瘤免疫治疗靶点的小分子,可用于高通量和高内涵筛选,是研究肿瘤免疫治疗的有力工具; | |||
DO1200 | 药物靶点库 | 53200 compounds | |
数量多,含53200种小分子化合物,是高通量筛选的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12316 |
Oral antiplatelet agent 1
|
Others | Others |
Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro. | |||
T20764 |
Dienestrol diacetate
NSC 81279,NSC81279,Cycladiene,Retalon-oral,Oestrasid C,NSC-81279 |
Others | Others |
Dienestrol diacetate, a derivative of the synthetic non-steroid phenolic compound, DIENESTROL, exhibits estrogenic activities. | |||
T19858 |
Brodimoprim
|
DHFR; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Brodimoprim 是甲氧苄啶的一种类似物,是口服有效的二氢叶酸还原酶抑制剂,对广谱革兰氏阴性和革兰氏阳性细菌具有高度的抑制作用。 | |||
T22341 |
GSK-114
|
Others | Others |
GSK 114 是口服有活性的、高选择性的TNNI3K 抑制剂 (IC50= 25 nM)。其中TNNI3K (又称 CARK) 是酪氨酸样激酶家族的成员,选择性在心脏组织中表达。它对 TNNI3K 的选择性是 B-Raf 激酶的 40 倍 (IC50= 1 µM)。 | |||
T31976 |
Glymidine sodium
|
Others | Others |
Glymidine sodium 是口服有活性的抗糖尿病药物,也是肝脂肪分解的抑制剂。它通过抑制葡萄糖的形成,也对由于内源性脂质动员抑制而导致的丙酮酸氧化升高具有抑制作用。 | |||
T20525 |
Chloramphenicol palmitate
|
Antibacterial; Antibiotic | Microbiology/Virology |
Chloramphenicol palmitate 是一种广谱抗生素,对革兰氏阳性和革兰氏阴性细菌具有活性。 Chloramphenicol palmitate 可用于在含有氯霉素抗性基因的转化细胞中作为细菌选择剂的研究。 | |||
T9680 |
Irloxacin
|
Antibacterial | Microbiology/Virology |
Irloxacin 是一种口服活性的喹诺酮类抗菌剂,在酸性条件下具有更强大的活性。在体外,Irloxacin 对革兰氏阳性菌和革兰氏阴性菌都具有良好的抗菌谱。 | |||
T9706 |
BTK inhibitor 17
|
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
BTK inhibitor 17 是口服有效的、不可逆的BTK 抑制剂,IC50为 2.1 nM。BTK inhibitor 17在类风湿关节炎方面有研究的价值。 | |||
T9121 |
AG-636
|
Dehydrogenase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
AG-636 是一种选择性可逆和具有口服活性的二氢乳清酸脱氢酶(DHODH)抑制剂,IC50 为 17 nM,具有很强的抗癌作用。 | |||
T5477 |
ELQ-300
|
Parasite | Microbiology/Virology |
ELQ-300 是一种有口服生物活性的抗疟疾剂,可作为细胞色素 bc1 复合物的还原位点的抑制剂 | |||
T9452 |
PW0787
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
PW0787 是一种可透过血脑屏障的,口服具有活性的GPR52选择性激动剂 (EC50=135 nM)。它能够抑制精神刺激行为。 | |||
T7436 |
Cilofexor
|
FXR; Autophagy | Autophagy; Metabolism |
Cilofexor 是一种法尼醇 X 受体激动剂,EC50为 43 nM。它抑制合成肽的结合,具有抗炎和抗纤维化作用。它可用于原发性硬化性胆管炎和非酒精性脂肪性肝炎的研究。 | |||
T16777 |
ROC-325
|
Apoptosis; Autophagy | Apoptosis; Autophagy |
ROC-325 是一种有效的口服活性自噬抑制剂,具有抗癌活性。 ROC-325 诱导肾细胞癌凋亡并表现出良好的特异性。 | |||
T11689 |
ITI-214
ITI214 |
PDE | Metabolism |
ITI-214 是一种中枢神经系统活性抑制剂,具有口服生物活性的PDE1抑制剂 (Kiof 58 pM),对其他 PDE 家族成员和一系列酶、受体、转运体和离子通道具有良好的选择性,在各种运动和认知功能的动物模型中显示出有效性。 | |||
T8850 |
sbp-7455
|
Autophagy | Autophagy |
SBP-7455 是一种高亲和力,可口服的双重ULK1/ULK2自噬抑制剂,可有效抑制ULK1/2酶活性,可研究三阴性乳腺癌,在 ADP-Glo 分析中的IC50分别为 13 nM 和 476 nM。 | |||
T10423 |
AWZ1066S
|
Parasite | Microbiology/Virology |
AWZ1066S 是一种高度特异性抗Wolbachia 的候选药物,可短期研究丝虫病,其在细胞中测得的EC50值为 2.5 nM。 | |||
T2282 |
RPI-1
|
Others; Phospholipase; c-Met/HGFR; c-RET | Apoptosis; Metabolism; Others; Tyrosine Kinase/Adaptors |
RPI1 是特异性的、口服具有活力的 2-吲哚啉酮Ret 酪氨酸激酶抑制剂,具有抗肿瘤作用。它能够抑制人甲状腺髓样癌 TT 细胞增殖、Ret 酪氨酸磷酸化、Ret 蛋白表达及 PLCgamma、ERKs 和 AKT 的活化。 | |||
T10539 |
BIBO3304 TFA
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
BIBO3304 TFA 是一种可口服的、选择性的神经肽 Y(NPY) Y1受体高效拮抗剂,对人和大鼠 Y1 受体均具有高亲和力,IC50分别为 0.38 和 0.72 nM。 | |||
T5315 |
TCA1
TCA-1,TCA 1 |
Antibacterial; Antibiotic | Microbiology/Virology |
TCA1 (TCA 1) 是一种小分子,具有抗耐药性和持续性结核病的活性。 | |||
T41277 |
PACMA 31
|
Others | Others |
PACMA 31 是一种不可逆的共价蛋白二硫键异构酶 (PDI) 抑制剂,IC50 为 10 μM。 PACMA 31 显着抑制卵巢肿瘤生长并表现出肿瘤靶向能力。 | |||
T9020 |
GSK620
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
GSK620 是一种有口服活性的泛BD2抑制剂,在人全血中表现出抗炎表型,有良好的广谱选择性、可开发性和体内口服药代动力学。它对 BET-BD2 家族蛋白具有高度选择性,其选择性超过所有其他 BET 溴结构域 200 倍以上。 | |||
T14358 |
Avoralstat
BCX4161 |
Others | Others |
Avoralstat (BCX4161) 是血浆激肽释放酶(PKK)抑制剂,具有口服活性,可用于遗传性血管性水肿的研究。 | |||
T9021 |
Ro0711401
Ro-0711401,Ro 0711401 |
GluR | Neuroscience |
Ro0711401 是一种可口服的 mGlu1受体选择性正变构调节剂,EC50为 56 nM。 | |||
T11723L |
JNJ-39758979
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
JNJ-39758979是一种选择性的、高亲和力的、可口服的组胺 H4 受体拮抗剂,具有抗炎和止痒作用,对人、小鼠和猴子的组胺 H4 受体的 Ki 值分别为 12.5、5.3 和 25 nM。它对组胺诱导的 cAMP 抑制作用具有拮抗作用,pA2 为 7.9。 | |||
T7388 |
GSK805
|
ROR | Metabolism |
GSK805 是能够生物利用的、具有 CNS 穿透性的 RORγt 抑制剂。 | |||
T5513 |
RO-3
|
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
RO3 是一种能透过大脑的P2X3和P2X2/3拮抗剂,口服有活性。它对人同型多聚体 P2X3和异型多聚体 P2X2/3受体的 pIC50分别为 5.9 和 7.0。 | |||
T4534 |
BMS-309403
|
FABP | Metabolism |
BMS309403 是有效的、选择性脂肪细胞脂肪酸结合蛋白 aFABP 抑制剂。它可改善载脂蛋白 E 缺乏症小鼠和培养的人内皮细胞的内皮功能。它能够与蛋白质内部的脂肪酸结合口袋相互作用,竞争性地抑制内源性脂肪酸的结合。 | |||
T9470 |
HPK1-IN-7
|
MAPK | MAPK |
HPK1-IN-7 是一种口服有活性的、有效的HPK1(造血祖细胞激酶1, MAP4K1) 抑制剂,其IC50值为2.6 nM,具有强大的家族及激酶组选择性。它对 IRAK4 (59 nM) 和 GLK (140 nM) 具有选择性。当它与抗 PD1联合使用时,对 MC38 同基因肿瘤模型表现出极大的疗效。 | |||
T16845 |
Sarolaner
PF-6450567 |
Others; Parasite | Microbiology/Virology; Others |
Sarolaner (PF-6450567) 是一种可口服的广谱外寄生虫剂,有效抑制狗身上的跳蚤和虱子,对C. felis 的 LC80值为 0.3 μg/mL,对O. turicata 的 LC100值为 0.003 μg/mL。 | |||
T7879 |
TASP0415914
|
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
TASP0415914 是一种具有口服活性的 PI3Kγ抑制剂,其 IC50=29 nM。它是一种 Akt 抑制剂,其 IC50=294 nM。它可用于研究炎症性疾病。 | |||
T3072 |
XL019
|
Apoptosis; FLT; JAK; PDGFR | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
XL019 是一种具有口服活性的选择性JAK2抑制剂。它对JAK2的选择性是 100 多种丝氨酸/苏氨酸和酪氨酸激酶的 50 倍以上。它对 JAK2 V617F 和野生型 JAK2 细胞中 STAT3 和 STAT5 磷酸化有抑制作用。 | |||
T15430 |
GSK2256294A
GSK 2256294 |
Others; Epoxide Hydrolase | Metabolism; Others |
GSK2256294A (GSK 2256294) 是重组人、大鼠和小鼠 sEH 的有效特异性抑制剂,IC50 分别为 27 pM、61 pM 和 189 pM。 | |||
T22708 |
Darglitazone
CP-86325 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Darglitazone (CP-86325) 是一种噻唑烷二酮,是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢,在 II 型糖尿病中有研究价值。 | |||
T9716 |
Ensitrelvir
S-217622 |
SARS-CoV | Microbiology/Virology |
Ensitrelvir (S-217622) 是首个口服有效的、非共价的、非肽的SARS-CoV-2 3CL 蛋白酶抑制剂,IC50为13 nM。 | |||
T2086 |
ELN-441958
ELN 441958 |
Bradykinin Receptor | GPCR/G Protein |
ELN-441958是一种B1受体拮抗剂,能够抑制B1激动剂配体[3H] DAKD 与IMR-90细胞结合(Ki:0.26 nM),相较于B2受体,它对B1受体的抑制作用具有更高的选择性,且比抑制μ阿片受体选择性高500多倍,比抑制δ阿片受体选择性高2000多倍。 | |||
T2007 |
RQ-00203078
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
RQ00203078是一种口服有效的TRPM8高选择性拮抗剂,对大鼠和人类TRPM8通道的IC50分别为 5.3 nM 和 8.3 nM。它对 TRPV1,TRPA1,TRPV4 或 TRPM2 通道基本没有抑制作用。 | |||
T6207 |
SC144
|
Apoptosis; Interleukin | Apoptosis; Immunology/Inflammation |
SC144 是一种口服活性 gp130 抑制剂。它结合 gp130,诱导 gp130 磷酸化(S782) 和去糖基化,消除 Stat3 磷酸化和核易位,进一步抑制下游靶基因的表达。它对 gp130 配体触发的信号转导有明显的抑制作用,可诱导人卵巢癌细胞凋亡。 | |||
T6400 |
AZD3514
|
Androgen Receptor | Endocrinology/Hormones |
AZD3514 是一种口服雄激素受体下调剂(Ki :2.2 μM),能够减少 AR 蛋白表达。 | |||
T1770 |
GNE-9605
|
LRRK2 | Autophagy |
GNE-9605 是一个高效,选择性和能脑渗透的LRRK2抑制剂,IC50为19 nM。 | |||
T1385 |
Amlodipine
氨氯地平,UK-48340 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Amlodipine (UK-48340) 是可口服的二氢吡啶钙通道阻滞剂,有抗心绞痛作用。它通过阻断电压依赖性的 L 型钙通道,从而抑制钙离子内流,用于高血压和癌症的研究。 | |||
T7537 |
Norgestimate
炔诺肟酯,诺孕酯 |
Progesterone Receptor | Others |
Norgestimate 是一种具有口服活性、高度选择性的孕激素活性和较小雄激素作用的孕激素,是一种合成的孕激素类似物。它可用作口服的避孕药。 | |||
T21981 |
Phthalazinone pyrazole
|
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂,IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。 | |||
T4584 |
BMS-813160
BMS 813160 |
CCR | Immunology/Inflammation; Microbiology/Virology |
BMS-813160 是CCR2/CCR5双重拮抗剂。有用于心血管的研究潜力。 | |||
T0152 |
Bosutinib
伯舒替尼,SKI-606 |
Bcr-Abl; Src; Autophagy | Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Bosutinib (SKI-606) 是一种合成的喹诺酮衍生物和双激酶抑制剂,靶向 Abl 和 Src 激酶的 IC50分别为 1 nM 和 1.2 nM。 | |||
T4337 |
PCI 29732
PCI29732,PCI-29732 |
Others; BCRP; BTK | Angiogenesis; Membrane transporter/Ion channel; Others; Tyrosine Kinase/Adaptors |
PCI 29732 是一种有效的可逆BTK 抑制剂,对 BTK、Lck 和 Lyn 的Kiapp 值分别为 8.2、4.6 和 2.5 nM。它通过竞争性结合ABCG2 的 ATP 结合位点来抑制ABCG2的功能。 | |||
T4697 |
ABBV-744
ABBV744 |
Epigenetic Reader Domain; HIV Protease | Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome |
ABBV-744 是一种 BDII 选择性 BET 溴结构域抑制剂,可抑制 BRD2/3/4。 它可研究炎症性疾病、癌症和艾滋病。 | |||
T13099 |
TC ASK 10
|
ASK; MAPK | Apoptosis; MAPK |
TC ASK 10 是选择性的,口服有效的细胞凋亡信号调节激酶 1 抑制剂,IC50为 14 nM。它对其他代表性激酶的抑制活性低于 50%,除 ASK2之外 (IC50为 0.51 μM)。 | |||
T10717 |
Inobrodib
CBP-IN-1 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
Inobrodib (CBP-IN-1) 是一种口服活性的强选择性p300/CBP 抑制剂,与 p300 和 CBP 结合,Kd 值为 1.3 和 1.7 nM。它抑制前列腺癌细胞系的细胞增殖并降低雄激素受体和 C-MYC 调节的基因表达。 | |||
T6700 |
Tenatoprazole
泰妥拉唑,TU-199 |
Proton pump | Membrane transporter/Ion channel |
Tenatoprazole (TU-199) 是一种口服有效的,基于咪唑吡啶的质子泵抑制剂。它抑制猪胃H+/K+-ATP 酶活性,IC50为6.2 μM。它阻断泛素与 ESCRT-1 因子 Tsg101 的相互作用,抑制几种包膜病毒的产生,包括 EBV。 | |||
T9786 |
Lu AF27139
|
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
Lu AF27139 是一种有效的选择性 P2X7 受体拮抗剂(人和大鼠的 IC50 分别为 12 和 2.4 nM,小鼠、人和大鼠的 Ki 分别为 22、54 和 13 nM)。 Lu AF27139 可用于中枢神经系统疾病研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0912L |
Tetracycline
Deschlorobiomycin,Tetracyclinum,Tetracyclin,四环素 |
Others; ribosome; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Tetracycline (Tetracyclin) 是一种对多种革兰氏阳性和革兰氏阴性细菌有抑制活性的广谱抗生素。 | |||
T41372 |
(22S,23S)-Homobrassinolide
油菜素内酯,SSHB |
Others | Others |
(22S,23S)-Homobrassinolide (SSHB) 在各种植物生物测定试验中均能诱导植物生长。 | |||
T2786 |
Oxysophocarpine
氧化槐树碱,氧卡地平 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Oxysophocarpine 是提取自海藻的生物碱。它对中枢神经系统和周围神经系统具有神经保护作用和抗伤害感受作用。 | |||
T7938 |
Quinidine
奎尼丁,奎宁树 |
Parasite | Microbiology/Virology |
Quinidine 是一种抗心律失常剂,也是 K+通道的有效阻断剂,其 IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂,也可研究疟疾。 | |||
T7964 |
Isomalt
异麦芽酮糖醇,Palatinitol,Palatinit |
Others; Dehydrogenase | Metabolism; Others |
Isomalt (Palatinitol) 是无毒的、具有良好耐受性的多元醇和蛋白质稳定的赋形剂,在冷冻干燥过程中可适度稳定乳酸脱氢酶(LDH),并在储存期间表现更好。它传统上在食品工业中用作甜味剂,也在制药中用作压片赋形剂。 | |||
T0301 |
Ethisterone
炔孕酮,17α-Ethynyltestosterone,Pregneninolone |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Ethisterone (17α-Ethynyltestosterone) 是一种口服活性类固醇避孕药,是一种合成类固醇雌激素。据报道,它具有雄激素活性,用于妇科疾病的研究。 | |||
T0247 |
Acarbose
阿卡波糖,BAY g 5421 |
Glucosidase | Metabolism |
Acarbose (BAY g 5421) 是一种具有口服具有活力 α-葡萄糖苷酶 (alpha-glucosidase) 抑制剂 (IC50=11 nM),是一种降糖药。它能提高磺脲类药物或胰岛素的降血糖作用。 | |||
T8516 |
Levomenol
没药醇,(-)-α-BISABOLOL,(-)-α-红没药醇 |
Others | Others |
Levomenol ((-)-α-BISABOLOL) 是一种单环倍半萜醇,具有有神经保护、抗氧化、抗炎和抗凋亡的作用。它可减轻三叉神经性疼痛啮齿动物模型的伤害性行为和中枢敏感性。它通过减少小鼠永久性局灶性脑缺血诱导的促炎标志物,防止神经元损伤和记忆缺陷。 | |||
T5S2360 |
Corydaline
Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline |
P450; Virus Protease; Opioid Receptor; AChE | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱,是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运,促进胃的调节,具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。 | |||
T0700 |
Ursodeoxycholic acid
熊去氧胆酸,UDCA,Ursodiol |
Potassium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
Ursodeoxycholic acid (UDCA)是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂,通过 FATP5 依赖性方式抑制原代肝细胞摄取长链脂肪酸。Ursodeoxycholic acid 能够抑制胆固醇的吸收,用于溶解胆结石,并具有研究与肥胖相关的脂肪肝疾病的潜力。 | |||
T12039 |
Miglustat
N-Butyldeoxynojirimycin,OGT918,美格鲁特,NB-DNJ,N-丙基脱氧野尻霉素 |
Others | Others |
Miglustat (NB-DNJ) 是一种葡萄糖神经酰胺合成酶抑制剂,可用于I 型戈谢病。 | |||
T0687 |
Simvastatin
辛伐他汀,MK-0733,MK 733 |
Apoptosis; Mitophagy; Ferroptosis; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Simvastatin (MK 733) 是一种 HMG-CoA 还原酶抑制剂 (Ki=0.2 nM),具有口服活性。Simvastatin 具有降血脂活性,可以抑制肝脏产生胆固醇,还可以用于预防心血管疾病。 | |||
T8125 |
Quinidine sulfate dihydrate
硫酸奎尼宁,硫酸奎尼丁二水合物,Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate |
P450 | Metabolism |
Quinidine sulfate dihydrate (Pitayine Sodium) 是抗心律失常剂,能够阻断 K+通道(IC50:19.9 μM)。它是细胞色素 P450db 的选择性抑制剂,可用于研究疟疾。 | |||
T2S1797 |
Santalol
檀香醇;白檀油萜醇;檀香脑,檀香醇 |
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
Santalol 是一种檀香醇的 α 和 β-异构体混合物。 其中α-santalol 分离自檀香油中,是一种有前途的抗癌药,能够预防口腔癌、前列腺癌、乳腺癌和皮肤癌。 | |||
T29078 |
Ursodeoxycholic acid sodium
UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium |
FXR; Endogenous Metabolite; GPCR19 | GPCR/G Protein; Metabolism |
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) 是一种天然存在的次级胆汁酸,具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子,通过与胆汁酸激活受体相互作用发挥其作用,包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。 | |||
TN1008 |
Psoralenoside
|
CaMK; Calcium Channel; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Psoralenoside 是源于补骨脂中的苯并呋喃苷,具有抗肿瘤、抗菌、促进成骨细胞增殖和雌激素样活性。它对组胺 H1、钙调素和电压门控 l 型钙通道具有较高的亲和力。 | |||
TN1343 |
8-Geranyloxypsoralen
8-香叶草氧基补骨脂素 |
Anti-infection; P450; BACE | Metabolism; Microbiology/Virology; Neuroscience |
8-Geranyloxypsoralen 是一种呋喃香豆素,分离自葡萄柚,是 P450 3A4 的有效抑制剂(IC50:3.93 μM)。 | |||
T3399 |
Psoralidin
|
Others; Estrogen/progestogen Receptor; Reactive Oxygen Species; Lipoxygenase; Gamma-secretase; Akt; COX; Antibacterial | Cytoskeletal Signaling; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Psoralidin 是COX-2和5-LOX 的抑制剂,有抗癌,抗菌和抗炎作用。它显著下调NOTCH1信号传导,还极大地诱导活化氧产生。 | |||
T2942 |
Psoralen
Ficusin,Furocoumarin,补骨脂素,psoralene |
Apoptosis; Influenza Virus; HIV Protease; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
Psoralen (Ficusin) 是从补骨脂种子中提取的一种香豆素。它具有如抗癌、抗氧化、抗抑郁、抗癌、抗菌、抗病毒等多种生物学特性。 | |||
TN1148 |
Isopsoralenoside
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Antibacterial | Endocrinology/Hormones; Microbiology/Virology |
Isopsoralenoside 是补骨脂多糖中的一种苯并呋喃苷。它在消化道内容物中可迅速代谢为补骨脂素。它具有雌激素样活性、促进成骨细胞增殖活性、抗肿瘤活性和抗菌活性。 | |||
TN6968 |
4",5"-dehydroisopsoralidin
|
||
4",5"-dehydroisopsoralidin is a natural product. | |||
T40636 |
8-(3-Ethoxy-2-hydroxy-3-methylbutyloxy)psoralen
|
Others | Others |
8-(3-Ethoxy-2-hydroxy-3-methylbutyloxy)psoralen is a coumarin compound present in Heracleum pyrenaicum Lam. | |||
TN4630 |
Nemoralisin
|
Others | Others |
Nemoralisin exhibits weak cytotoxicities (IC50>10 uM) against HepG2, AGS, MCF-7, and A-549 cancer cell lines. | |||
TN4629 |
Nemoralisin C
|
Others | Others |
Nemoralisin C shows antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines. | |||
TN2425 |
5,8-Dihydroxypsoralen
|
Others | Others |
5,8-Dihydroxypsoralen is a natural product from Pueraria lobata (Willd.) Ohwi | |||
TN3281 |
8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen
|
Others | Others |
8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen是一种天然产物,属于豆科补骨脂属,其产品编号为 TN3281,CAS号为 425680-98-4。8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen可用作对照参考。 | |||
TN3267 | 8-(7-Hydroxy-3,7-dimethyl-2,5-octadienyloxy)psoralen | Others | Others |
8-(7-Hydroxy-3,7-dimethyl-2,5-octadienyloxy)psoralen 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3267,CAS号为 144398-34-5。 | |||
TN3266 |
8-(6-Hydroperoxy-3,7-dimethyl-2,7-octadienyloxy)psoralen
|
Others | Others |
8-(6-Hydroperoxy-3,7-dimethyl-2,7-octadienyloxy)psoralen 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3266,CAS号为 151121-39-0。 | |||
TN6298 |
8-[(6,7-Dihydroxy-3,7-dimethyloct-2-en-1-yl)oxy]psoralen
|
||
8-[(6,7-Dihydroxy-3,7-dimethyloct-2-en-1-yl)oxy]psoralen 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6298,CAS号为 889112-17-8。 | |||
T40859 |
5-Hydroxy-8-methoxypsoralen
5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen |
Others | Others |
5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight. | |||
TN7367 |
trans-Psoralenoside
|
Others | Others |
Trans-Psoralenoside exhibits hepatoprotective (liver-protective), nephroprotective (kidney-protective), antiulcer, and anticoagulant properties. | |||
TN6711 |
toralactone
|
Others; Nrf2 | Immunology/Inflammation; Others |
Toralactone 是一种分离自决明子中的天然产物,通过 Nrf2 依赖性抗氧化机制介导肝脏保护作用。 | |||
T20198 |
Potassium gluconate
Kalium-beta,Kalium Gluconate,Kaon elixir,Kaon,Potassium D-gluconate,HSDB 3165,K-Iao |
Endogenous Metabolite; Antifungal | Metabolism; Microbiology/Virology |
Potassium gluconate (Potassium D-gluconate) 是一种具有口服活性和螯合性质的氧化型羧酸,具有杀菌活性。 | |||
T8263 |
3,4'-Dihydroxyflavone
|
Influenza Virus | Microbiology/Virology |
3,4'-Dihydroxyflavone 是一种口服活性黄酮类化合物,具有抗甲型流感病毒的抗病毒活性。 | |||
T2737 |
Neohesperidin
Hesperetin 7-O-neohesperidoside,NSC 31048,新橙皮苷 |
Antioxidant | oxidation-reduction |
Neohesperidin (NSC-31048) 是一种类黄酮化合物,存在于葫芦科植物中,具有抗氧化和抗炎活性。 | |||
TN1990 |
Norathyriol
芒果苷元 |
Akt; DNA/RNA Synthesis; AMPK; PPAR | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Norathyriol 是来自芒果的芒果苷代谢物,具有抗氧化、抗癌、抗菌和抗炎活性。它以非竞争性方式抑制 α-葡萄糖苷酶,IC50为 3.12 μM。它还抑制PPARα、PPARβ和PPARγ,IC50分别为 92.8、102.4 和 153.5 µM。 | |||
T4709 |
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
盐酸 D-甘露糖胺,D-Mannosamine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride (D-Mannosamine hydrochloride) 是内源性代谢产物的一种。 | |||
T1424 |
Ethynyl estradiol
乙炔基雌二醇,17α-Ethynylestradiol,Ethinyl Estradiol,炔雌醇 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Ethynyl estradio 是一种高效的生物活性雌激素。 | |||
TN2023 |
8-Oxoepiberberine
氧化表小檗碱,Oxyepiberberine |
Others | Others |
8-Oxoepiberberine (Oxyepiberberine) 是口服左金方剂后血清中产生的生物碱代谢物。其中左金方剂是一种中药,可以用于胃肠道疾病的研究。 | |||
T5S2245 |
Alisol C 23-acetate
泽泻醇 C-23-醋酸酯,Alisol C monoacetate |
Others | Others |
Alisol C 23-acetate (Alisol C monoacetate) 是一种提取自东方泽泻中的天然产物,可以显著减少迟发型超敏反应。 | |||
T1687 |
Doxycycline
Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素 |
MMP; ribosome; Antibacterial; Antibiotic; Parasite | Microbiology/Virology; Proteases/Proteasome |
Doxycycline (Doxiciclina) 属于四环素类抗生素,是一种广谱的金属蛋白酶 (MMP) 抑制剂,具有口服活性。Doxycycline 具有抗菌活性和抗肿瘤活性。 | |||
T5746 |
Dictamine
Dictamnine,Dectamine,白鲜碱 |
Apoptosis; Anti-infection; Antibacterial; Antifungal | Apoptosis; Microbiology/Virology |
Dictamine (Dectamine) 显示抗胆碱酯酶、抗炎、致突变、抗菌和抗真菌活性。 它具有在人子宫颈、结肠和口腔癌细胞中发挥细胞毒性的能力。 | |||
T1687L |
Doxycycline (hyclate)
Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate |
MMP; ribosome; Antibacterial; Antibiotic | Microbiology/Virology; Proteases/Proteasome |
Doxycycline hyclate (WC2031) 属于四环素类抗生素,是一种广谱的金属蛋白酶 (MMP) 抑制剂,具有口服活性。Doxycycline hyclate 具有抗菌活性和抗肿瘤活性。 | |||
T1508 |
Decitabine
Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA Methyltransferase | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Decitabine (Deoxycytidine) 是脱氧胞苷类似物,一种 DNA 甲基转移酶抑制剂,具有口服活性。Decitabine 具有抗肿瘤活性和抗代谢活性。Decitabine 诱导细胞周期阻滞和凋亡。 | |||
TN7238L |
Sanguinarine citrate
Sanguinarium citrate,Sanguinarin citrate,Pseudochelerythrine citrate |
Antibiotic | Microbiology/Virology |
Sanguinarine citrate (Pseudochelerythrine chloride) 是一种来源于 Sanguinaria Canadensis 的生物碱,具有抗菌、抗炎和镇痛活性,可用于治疗口腔炎、牙龈出血和喉炎等口腔炎症疾病 。 | |||
TJS0928 |
Calenduloside E
去葡萄糖竹节参皂苷,Silphioside F |
Others | Others |
Calenduloside E (Silphioside F) 是从辽东楤木中提取的一种五环三萜皂苷。它靶向热休克蛋白90 (Hsp90) ,具有抗凋亡作用。 | |||
TN2031 |
γ-Terpinene
Moslene,p-Mentha-1,4-diene,Crithmene |
Antioxidant | oxidation-reduction |
γ-Terpinene (p-Mentha-1,4-diene) 是一种单萜化合物,具有高抗氧化属性,适合口服。它展示了直接的自由基清除能力,并且已知是一种有效的抗痛剂。 | |||
T6564 |
Leupeptin Hemisulfate
亮肽素 |
Serine Protease; Cysteine Protease | Proteases/Proteasome |
Leupeptin hemisulfate 是一种蛋白酶抑制剂,具有细胞膜渗透性、可逆性、竞争性和口服活性。Leupeptin hemisulfate 可以抑制 Cathepsin B、Cathepsin H、Cathepsin L 的活性,阻断两性溶酶体的融合。Leupeptin hemisulfate 还具有抗炎活性。 | |||
T3400 |
Bakuchiol
|
p38 MAPK; DNA/RNA Synthesis; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK |
Bakuchiol 是一种从补骨脂种子中提取的植物雌激素,具有抗肿瘤和抗蠕虫特性,以及细胞毒活性和抗菌活性。 | |||
T2803 |
Monocrotaline
野百合碱,Crotaline |
TGF-beta/Smad | Stem Cells |
Monocrotaline (Crotaline) 是一种吡咯里西啶生物碱,从猪屎豆植物的种子中提取得到,可诱导啮齿动物产生肺动脉高血压。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03589 |
PsaA Protein, S. oralis, Recombinant (His & Myc)
Manganese ABC transporter substrate-binding lipoprotein PsaA... |
Streptococcus oralis | E. coli |
Part of an ATP-driven transport system. PsaA Protein, S. oralis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 40.1 kDa and the accession number is Q9L5W9. | |||
TMPY-01061 |
FGF-10 Protein, Human, Recombinant
fibroblast growth factor 10,KGF2 |
Human | E. coli |
Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 pla... | |||
TMPJ-00042 |
TSLP Protein, Human, Recombinant
TSLP,Thymic stromal lymphopoietin |
Human | E. coli |
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral... | |||
TMPY-03225 |
VSIG8 Protein, Human, Recombinant (hFc)
C1orf204,V-set and immunoglobulin domain containing 8 |
Human | HEK293 Cells |
V-set and immunoglobulin domain containing 8 (VSIG8) is essential in hair cycle, oral mucosa, and the nail matrix. Moreover, VSIG8 also has an important role in proper epithelial differentiation and function in the upper alimentary tract. | |||
TMPH-02336 |
TAS2R10 Protein, Human, Recombinant (His & KSI)
Taste receptor family B member 2,Taste receptor type 2 membe... |
Human | E. coli |
Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. TAS2R10 Protein, Human, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 19.6 kDa and the accession number is Q9NYW0. | |||
TMPY-03851 |
BPIFB1 Protein, Human, Recombinant (His)
LPLUNC1,BPI fold containing family B, member 1,C20orf114 |
Human | HEK293 Cells |
BPIFB1, also known as LPLUNC1, belongs to the BPI/LBP/Plunc superfamily, plunc family. BPIFB1 may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. BPIFB1 is expressed in the upper respiratory tract and oral cavity, which may function in host defence. The expression of BPIF proteins is associated with CF lung disease in humans and mice. It is unclear if this elevation of protein production, which results from phenotypic alteration of the cel... | |||
TMPJ-00157 |
CD82 Protein, Human, Recombinant (hFc)
Tetraspanin-27,KAI1,ST6,TSPAN27,TSPAN274F9,CD82 molecule,Tsp... |
Human | HEK293 Cells |
CD82 antigen, also known as Kai-1, is a widely expressed palmitoylated molecule of the tetraspanin superfamily. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signaling. CD82/Kai-1 is a component of the promiscuous TIMP-1 interacting protein complex on the cell surface of human adenocarcinoma cells and gives insight into tumorigenic metastatic potential. CD82/Kai-1... | |||
TMPH-03155 |
Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc)
Lys-gingipain HG66,kgp |
Porphyromonas gingivalis | E. coli |
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc) is expressed in E.... | |||
TMPH-03154 |
Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His)
kgp,Lys-gingipain 381 |
Porphyromonas gingivalis | E. coli |
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli e... | |||
TMPJ-00860 |
HTN3 Protein, Human, Recombinant
HTN3,Histidine-rich protein 3,Histatin-3,Basic histidine-ric... |
Human | E. coli |
HTN3 belongs to the histatin/statherin family. Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. Post-translational proteolytic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins 1 and 3 are primary products of HIS1and HIS2 alleles, respectively. Histatins are be... | |||
TMPY-03971 |
Statherin Protein, Human, Recombinant (mFc)
statherin,STATH,STR |
Human | HEK293 Cells |
Statherin, also known as STATH, belongs to the histatin/statherin family. Statherin may play an important role in the maintenance of oral health. It prevents calcium phospate precipitation in saliva, so maintaining a high calcium level in saliva and preventing teeth from dissolving. Statherin also inhibits spontaneous precipitation of calcium phosphate salts. Thus, statherin and PRPs may prevent build-up of harmful deposits in the salivary glands and on the tooth surfaces. Statherin is a highly ... | |||
TMPH-03156 |
Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO)
Lysine-specific cysteine proteinase Kgp,Lys-gingipain,kgp |
Porphyromonas gingivalis | E. coli |
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO) is expressed in E. col... | |||
TMPJ-00160 |
EMMPRIN/CD147 Protein, Human, Recombinant (His)
5F7,TCSF,OK Blood Group Antigen,Tumor Cell-Derived Collagena... |
Human | HEK293 Cells |
Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) belongs to the immunoglobulin superfamily, which has the homology to both the immunoglobulin V domain and MHC class II antigen β-chain. EMMPRIN is a transmembrane glycoprotein with different forms, resulting from different modes of glycosylation and N-terminal sequence variants. EMMPRIN can be expressed in breast cancer, oral squamous cell carcinoma, glioma, lymphoma, lung, bladder, and melanoma carcinomas cells. EMMPRIN promotes invasion,... | |||
TMPJ-00764 |
Catalase/CAT Protein, Human, Recombinant
CAT,Catalase |
Human | E. coli |
Catalase (CAT) is a member of the catalase family. It exists as a homotetramer that occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Catalase is localized in the peroxisome. Catalase promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells, and normal and transformed fibroblast cells. Defects in CAT are the cause of acatalasemia which is characterized by absence of ... | |||
TMPH-00331 |
ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc)
Adhesin 3,3D9 antigen,Agglutinin-like protein 3 |
Candida albicans | E. coli |
Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. ALS3 Prot... | |||
TMPY-03332 |
PRTFDC1 Protein, Human, Recombinant (His)
HHGP,PRTFDC1,phosphoribosyl transferase domain containing 1 |
Human | E. coli |
PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a sever... | |||
TMPJ-01207 |
UPP1 Protein, Human, Recombinant (His)
UPP1,Uridine Phosphorylase 1,UPP1 Protein |
Human | E. coli |
Uridinephosphorylase 1 (UPP1) is a member of the family of pentosyltransferase. UPP1 catalyses the reversible phosphorolysis of uridine to uracil. The expression levels and the enzymatic activity of UPP1 are higher in human solid tumors than in adjacent normal tissues. The high level of UPP1 expression in some tumors makes it a potential prognosticfactor for some cancers, such as oral squamous cell carcinoma. UPP1 is important for the homeostatic regulation of intracellular and plasma uridine c... | |||
TMPY-04170 |
DEFB1 Protein, Human, Recombinant (hFc)
DEFB101,defensin, β1,β Defensin 1/DEFB1,defensin, beta 1,DEF... |
Human | HEK293 Cells |
The DEFB1 gene, encoding for the constitutively expressed human beta-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been reported as contributing to hBD1 production impairment, leading to a greater susceptibility to be infected by oral pathogens, also leading to periodontitis. To counteract host immunity, Cryptosporidium parvum has evolved multiple strategies to suppress host antimicrobial defense. On... | |||
TMPJ-01372 |
Cornulin Protein, Human, Recombinant (His)
Tumor-Related Protein,58 kDa Heat Shock Protein,PDRC1,C1orf1... |
Human | E. coli |
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and ... | |||
TMPJ-01173 |
TFF3 Protein, Mouse, Recombinant (His)
Itf,Trefoil factor 3,Intestinal trefoil factor,mITF,Tff3 |
Mouse | HEK293 Cells |
Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process called restitution. TFF comprises the gastric peptides (TFF1), spasmolytic peptide (TFF2), and the intestinal trefoil factor (TFF3). They have an important and necessary role in epithelial restitution within the gastrointestinal tract. Members of the trefoil family are characterized b... | |||
TMPH-00672 |
Metalloprotease stcE Protein, E. coli O157:H7, Recombinant (His)
stcE,Neutral zinc metalloprotease StcE,Metalloprotease StcE,... |
E. coli | E. coli |
Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as... | |||
TMPY-02391 |
SUMO1 Protein, Human, Recombinant (His)
small ubiquitin-like modifier 1,SMT3C,SMT3,SMT3H3,UBL1,SENP2... |
Human | E. coli |
Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX act... | |||
TMPY-02220 |
HRAS Protein, Human, Recombinant (His)
HAMSV,Harvey rat sarcoma viral oncogene homolog,C-H-RAS,C-HA... |
Human | Baculovirus Insect Cells |
HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS). FCSS is a rare condition characterized by prenatally increase... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11067 |
VX-984
M9831 |
DNA-PK | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用,可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。 | |||
T13137 |
TGFβRI-IN-1
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TGF-beta/Smad | Stem Cells |
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively ). | |||
T12292 |
Olaparib-d5
KU0059436 D5,AZD2281 D5,Olaparib D5 |
Others | Others |
Olaparib D5 is a deuterium labeled Olaparib. Olaparib is a potent and oral inhibitor of PARP. | |||
T11088 |
Doxepin D3 Hydrochloride
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepin hydrochloride is also an effective CYP450 inhibitor, significantly inhibiting CYP450 2C19 and | |||
TMIJ-0132 |
Edoxaban-d6
|
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Edoxaban-d6 是 Edoxaban 的氘代化合物。Edoxaban 的 CAS 号为 480449-70-5。Edoxaban 是一种口服 Xa 因子 (FXa) 抑制剂,用于中风预防的临床开发。 | |||
TMIH-0322 |
Mebeverine Acid-d5
|
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Mebeverine Acid-d5 是 Mebeverine Acid 的氘代化合物。Mebeverine Acid 的 CAS 号为 475203-77-1。Mebeverine acid 是美贝维林的次级代谢产物,可用作口服美贝维林的标志物。 | |||
TMIJ-0225 |
Finasteride-d9
|
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Finasteride-d9 是 Finasteride 的氘代化合物。Finasteride 的 CAS 号为 98319-26-7。Finasteride 是 5α-还原酶的竞争性抑制剂,对 II 型 5α-还原酶的IC50为 4.2 nM,对 II 型 5α-还原酶的亲和力是 I 型酶的 100 倍。它可用于研究前列腺增生和雄激素性脱发。 | |||
TMIH-0253 |
Gliclazide-d7
|
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Gliclazide-d7 是 Gliclazide 的氘代化合物。Gliclazide 的 CAS 号为 21187-98-4。Gliclazide 是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂,IC50为 184 nM,用作降糖药。 | |||
TMID-0139 |
17α-Ethynylestradiol-2,4,16,16-d4
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17α-Ethynylestradiol-2,4,16,16-d4 是 17α-Ethynylestradiol 的氘代化合物。17α-Ethynylestradiol 的 CAS 号为 57-63-6。Ethynyl Estradiol 是一种高效的生物活性雌激素。 | |||
TMIH-0102 |
Avatrombopag-d8
|
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Avatrombopag-d8 是 Avatrombopag 的氘代化合物。Avatrombopag 的 CAS 号为 570406-98-3。Avatrombopag 是一种新型口服血小板生成素 (TPO) 受体激动剂,可激活 TPO 受体并增加巨核细胞增殖/分化和血小板生成。 | |||
TMIJ-0077 |
Clevidipine-d7
|
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Clevidipine-d7 是 Clevidipine 的氘代化合物。Clevidipine 的 CAS 号为 167221-71-8。Clevidipine butyrate 是一种二氢吡啶 L 型钙通道阻滞剂,IC50为7.1 nM。它对血管平滑肌有选择性,可用于降低血压。 | |||
TMIH-0591 |
Vadadustat-13C2-15N
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Vadadustat-13C2-15N 是 Vadadustat 的 13C 和 15N 的标记化合物。Vadadustat 的 CAS 号为 1000025-07-9。Vadadustat 是一种可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂,是一种促红细胞生成剂,在动物慢性肾脏疾病模型中,有用于贫血的研究潜力。 | |||
TMID-0003 |
Ribociclib-d6
|
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Ribociclib-d6 是 Ribociclib 的氘代化合物。Ribociclib 的 CAS 号为 1211441-98-3。Ribociclib (LEE011) 是一种细胞周期蛋白依赖性激酶 CDK4/6 抑制剂 (IC50=10/39 nM),具有特异性和口服活性。Ribociclib 具有抗肿瘤活性,可以阻滞细胞周期,抑制肿瘤细胞增殖。 | |||
TMIJ-0327 |
Cefpodoxime-d3 Acid
|
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Cefpodoxime-d3 Acid 是 Cefpodoxime Acid 的氘代化合物。Cefpodoxime Acid 的 CAS 号为 80210-62-4。Cefpodoxime (free acid) 是一种口服的第三代头孢菌素抗生素。除铜绿假单胞菌、肠球菌和脆弱拟杆菌外,它对大多数革兰氏阳性和革兰氏阴性微生物均有效。 | |||
T71205 |
Fosinopril-d7 sodium salt
|
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Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti... | |||
TMID-0290 |
Cefpodoxime proxetil-d3
|
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Cefpodoxime proxetil-d3 是 Cefpodoxime proxetil 的氘代化合物。Cefpodoxime proxetil 的 CAS 号为 87239-81-4。Cefpodoxime Proxetil 是一种口服的广谱型抗生素。它与青霉素结合蛋白结合,抑制肽聚糖的合成,干扰细菌细胞壁的生物合成。 | |||
T35698 |
Octanoic Acid-13C
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Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d... | |||
TMIJ-0114 |
Vardenafil-d5
|
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Vardenafil-d5 是 Vardenafil 的氘代化合物。Vardenafil 的 CAS 号为 224785-90-4。Vardenafil 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂,IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解,从而提高 cGMP 水平。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。 | |||
TMIJ-0272 |
Sarpogrelate-d3 HCl
|
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Sarpogrelate-d3 HCl 是 Sarpogrelate HCl 的氘代化合物。Sarpogrelate HCl 的 CAS 号为 135159-51-2。Sarpogrelate hydrochloride 是一种选择性5-HT2R拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi值分别为 8.52、6.57 和 7.43。 |