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NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers.
NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 1,980 | 6-8周 | |
25 mg | ¥ 8,400 | 6-8周 | |
50 mg | ¥ 10,800 | 6-8周 | |
100 mg | ¥ 14,900 | 6-8周 |
产品描述 | NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers. |
体外活性 | NSC745885 (0.5-4 μM; 24 hours) enhances annexin V positive cells in a dose-dependent manner, and the differences appear as a dose-dependent manner. NSC745885 (0.5-2 μM; 24 or 48 hours) reduces XIAP protein levels and increases protein levels both as a dose-dependent manner in SAS cells. NSC745885 (0.5-4 μM; 24, 48 or 72 hours) has a growth inhibitory or death-promoting effect on the SAS cells, it significantly decreases the densities of cultured cells when compared with untreated cells. The IC50 of NSC745885 is 0.85 μM after 72 hours' treatment [1]. |
体内活性 | NSC745885 (intraperitoneal injection; 2 mg/kg; once daily; 10 days) treatment obviously decreases tumor size when compared with the vehicle control. It shows higher safety than doxorubicin[1]. |
分子量 | 266.27 |
分子式 | C14H6N2O2S |
CAS No. | 4219-52-7 |
密度 | 1.574 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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