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Pirlindole作为一种可逆的单胺氧化酶A (RIMA) 抑制剂,主要在俄罗斯作为抗抑郁化合物开发并使用。它在结构和药理学上与metralindole相似。Pirlindole已在一些欧洲和非欧洲国家批准用于治疗抑郁症。其口服绝对生物利用度为20%至30%,主要因为显著的首过效应。对于大鼠而言,其口服Tmax在2.5至6小时之间变化;对于狗,该值在0.8至2小时之间。
Pirlindole作为一种可逆的单胺氧化酶A (RIMA) 抑制剂,主要在俄罗斯作为抗抑郁化合物开发并使用。它在结构和药理学上与metralindole相似。Pirlindole已在一些欧洲和非欧洲国家批准用于治疗抑郁症。其口服绝对生物利用度为20%至30%,主要因为显著的首过效应。对于大鼠而言,其口服Tmax在2.5至6小时之间变化;对于狗,该值在0.8至2小时之间。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Pirlindole, a reversible inhibitor of monoamine oxidase A (RIMA), has been developed and used primarily as an antidepressant compound in Russia. Structurally and pharmacologically, it is similar to metralindole. Pirlindole has received approval for the treatment of depression in several European and non-European countries. Its oral absolute bioavailability ranges from 20% to 30%, mainly due to significant first-pass metabolism. In rats, the oral Tmax varies between 2.5 and 6 hours, while in dogs, it ranges from 0.8 to 2 hours. |
别名 | Pyrazidole, Pyrazidol, Pirlindole hydrochloride, 8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride |
分子量 | 262.78 |
分子式 | C15H19ClN2 |
CAS No. | 16154-78-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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