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Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) 是一种双重 Bcl-2 和 Bcl-xl 抑制剂(IC50:2 nM 和 5.9 nM),具有抗肿瘤活性。
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) 是一种双重 Bcl-2 和 Bcl-xl 抑制剂(IC50:2 nM 和 5.9 nM),具有抗肿瘤活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,390 | 现货 | |
5 mg | ¥ 3,390 | 现货 | |
10 mg | ¥ 4,720 | 现货 | |
25 mg | ¥ 6,870 | 现货 | |
50 mg | ¥ 9,480 | 现货 | |
100 mg | ¥ 12,700 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 4,770 | 现货 |
产品描述 | Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells. |
靶点活性 | BCL-XL:5.9 nM, BCL2:2 nM |
体外活性 | Lisaftoclax在Bcl-2依赖的RS4 11细胞和Bcl-xl依赖的Molm 13细胞中的IC50值为 5.5 nM和6.4 nM[1]。 |
别名 | Bcl-2/Bcl-xl inhibitor 1, APG-2575 |
分子量 | 882.42 |
分子式 | C45H48ClN7O8S |
CAS No. | 2180923-05-9 |
Smiles | [O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1 |
密度 | 1.48 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 45 mg/mL (51 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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