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Procollagen C-endopeptidase (procollagen C-terminal proteinase, carboxyprocollagen peptidase, procollagen C-terminal peptidase, procollagen C-proteinase, procollagen carboxypeptidase, procollagen carboxy-terminal proteinase, procollagen peptidase) is an enzyme. This enzyme catalyses the following chemical reaction, Cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III. This endopeptidase belongs to the peptidase family M12 (astacin family).