|
TMPY-04380
|
DYRK3 Protein, Human, Recombinant (His & GST)
REDK,RED,DYRK5,dual-specificity tyrosine-(Y)-phosphoryla...
|
Human
|
Baculovirus Insect Cells
|
|
Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains oneprotein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hemat... |
|
TMPY-01085
|
VLDLR Protein, Human, Recombinant (His)
VLDLRCH,CAMRQ1,CHRMQ1,very low density lipoprotein receptor,...
|
Human
|
HEK293 Cells
|
|
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is ... |
|
TMPY-04548
|
CDK4 Protein, Human, Recombinant (GST)
CMM3,PSK-J3,cyclin-dependent kinase 4
|
Human
|
Baculovirus Insect Cells
|
|
CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser... |
|
TMPJ-00166
|
SCF Protein, Mouse, Recombinant
SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel...
|
Mouse
|
E. coli
|
|
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ... |
|
TMPY-02603
|
STAT6 Protein, Human, Recombinant (His)
STAT6C,IL-4-STAT,STAT6B,signal transducer and activator of t...
|
Human
|
Baculovirus Insect Cells
|
|
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators... |
|
TMPH-02271
|
BTK Protein, Human, Recombinant (His)
BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine-protein kina...
|
Human
|
Baculovirus Insect Cells
|
|
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in... |
|
TMPY-05004
|
FGF-4 Protein, Human, Recombinant
HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4
|
Human
|
E. coli
|
|
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a... |
|
TMPY-04572
|
MKK4 Protein, Mouse, Recombinant (His & GST)
MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated protein ...
|
Mouse
|
Baculovirus Insect Cells
|
|
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ... |
|
TMPY-04544
|
MEK2 Protein, Human, Recombinant (GST)
mitogen-activated protein kinase kinase 2,FLJ26075,MKK2,CFC4...
|
Human
|
Baculovirus Insect Cells
|
|
Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ... |
|
TMPY-04396
|
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...
|
Human
|
Baculovirus Insect Cells
|
|
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... |
|
TMPH-03764
|
YAP1 Protein, Human, Recombinant (His)
YAP1-2gamma,YAP2L,YAP65
|
Human
|
P. pastoris (Yeast)
|
|
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,... |
|
TMPH-00720
|
PsuK Protein, E. coli, Recombinant (His & Myc)
Pseudouridine kinase,psuK
|
E. coli
|
E. coli
|
|
Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP). |
|
TMPH-00710
|
PEP synthase Protein, E. coli, Recombinant (His & SUMO)
ppsA,Phosphoenolpyruvate synthase,Pyruvate, water dikinase
|
E. coli
|
E. coli
|
|
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. |
|
TMPY-04568
|
PDK1 Protein, Human, Recombinant (His)
pyruvate dehydrogenase kinase, isozyme 1,PDHK1
|
Human
|
Baculovirus Insect Cells
|
|
Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantly in the heart. It contains one histidine kinase domain. Pyruvate dehydrogenase kinase (PDK) isoforms are molecular switches that downregulate the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation in mitochondria. An inhibitory effect of lipoic acid on PDKs would... |
|
TMPH-02214
|
Tomoregulin-1 Protein, Human, Recombinant (His)
TMEFF2,Tomoregulin-2,Transmembrane protein with EGF-like and...
|
Human
|
HEK293 Cells
|
|
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. |
|
TMPH-00400
|
DHAK Protein, Citrobacter freundii, Recombinant (His & SUMO)
Dihydroxyacetone kinase,dhaK,Glycerone kinase,DHA kinase
|
Citrobacter freundii
|
E. coli
|
|
Catalyzes the phosphorylation of dihydroxyacetone. DHAK Protein, Citrobacter freundii, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.9 kDa and the accession number is P45510. |
|
TMPH-00515
|
PPDK Protein, Entamoeba histolytica, Recombinant (His & SUMO)
PPDK,Pyruvate, orthophosphate dikinase,Pyruvate, phosphate d...
|
Entamoeba histolytica
|
E. coli
|
|
Catalyzes the reversible phosphorylation of pyruvate and phosphate. In E.histolytica and C.symbiosus, PPDK functions in the direction of ATP synthesis. |
|
TMPJ-01121
|
MORF4L2 Protein, Human, Recombinant (His)
MORF4L2,Transcription Factor-Like Protein MRGX,Protein MSL3-...
|
Human
|
E. coli
|
|
Mortality Factor 4-Like Protein 2 (MORF4L2) is a member of the mortality factor (MORF) family. MORF4L2 localizes in the nucleus, possessing a protein kinase C phosphorylation site and a tyrosine phosphorylation site. MORF4L2 interacts with the Rb tumor suppressor and it has histone deacetylase activity which can either repress or promote the activity of the B-Myb promoter depending on the tissue. In addition, MORF4L2 is involved in cell growth, regulation, and senescence. |
|
TMPH-02811
|
NRK1 Protein, Mouse, Recombinant (His)
Ribosylnicotinamide kinase 1,Nmrk1,Ribosylnicotinic acid kin...
|
Mouse
|
E. coli
|
|
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). |
|
TMPY-02032
|
FLRT1 Protein, Human, Recombinant (His)
SPG68,fibronectin leucine rich transmembrane protein 1
|
Human
|
HEK293 Cells
|
|
The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicates a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation ... |
|
TMPH-02135
|
SPRED1 Protein, Human, Recombinant (His & Myc & SUMO)
SPRED1,Sprouty-related, EVH1 domain-containing protein 1
|
Human
|
E. coli
|
|
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells. SPRED1 Protein, Human, Reco... |
|
TMPH-00639
|
Hygromycin-B 4-O-kinase Protein, E. coli, Recombinant (His)
Hygromycin B phosphotransferase,hph,Hygromycin-B kinase,Hygr...
|
E. coli
|
E. coli
|
|
The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin. |
|
TMPH-02648
|
PKDCC Protein, Mouse, Recombinant (His & Myc)
Extracellular tyrosine-protein kinase PKDCC,Vertebrate lones...
|
Mouse
|
Baculovirus Insect Cells
|
|
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membr... |
|
TMPJ-00922
|
DCK Protein, Human, Recombinant (His & T7)
DCK,Deoxycytidine Kinase
|
Human
|
E. coli
|
|
Deoxycytidine Kinase (DCK) is a member of the DCK/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG), and deoxyadenosine (dA). DCK has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. In addition, DCK is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and c... |
|
TMPY-04425
|
PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)
PRAK,MAPKAP-K5,MK-5,mitogen-activated protein kinase-activat...
|
Human
|
Baculovirus Insect Cells
|
|
MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK). It is widely distributed. MAPKAPK5 can be phosphorylated by an extracellular-regulated kinase (ERK), and p38 kinase but not by c-jun N-terminal kinase (JNK)in vitro. Recombinant GST-MAPKAPK5 protein can phosphorylate a peptide derived from the regulator... |
|
TMPH-02126
|
SORBS2 Protein, Human, Recombinant (His)
Sorbin and SH3 domain-containing protein 2,Arg-binding prote...
|
Human
|
E. coli
|
|
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. SORBS2 Pro... |
|
TMPH-00157
|
Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His)
dTMP kinase,tmk,Thymidylate kinase
|
Bacillus anthracis
|
E. coli
|
|
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.8 kDa and the accession number is C3LJ02. |
|
TMPH-01585
|
Ketohexokinase/KHK Protein, Human, Recombinant (GST)
Hepatic fructokinase,KHK,Ketohexokinase
|
Human
|
E. coli
|
|
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. Ketohexokinase/KHK Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 59.7 kDa and the accession number is P50053. |
|
TMPJ-01261
|
PPP1R14A Protein, Human, Recombinant (His)
17 kDa PKC-Potentiated Inhibitory Protein of PP1,CPI17,PPP1R...
|
Human
|
E. coli
|
|
Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA su... |
|
TMPY-03261
|
CNPY2 Protein, Human, Recombinant (His)
canopy FGF signaling regulator 2,HP10390,ZSIG9,MSAP,TMEM4
|
Human
|
HEK293 Cells
|
|
CNPY2 is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. CNPY2 enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. It is expressed in different tissues, including brain. Overexpression of CNPY2 enhanced the motility of glioma cells measured in matrigel invasion chambers and using a scratch assay. Downregulation of CNPY2 by RNA interference significantly decreased glioma cell migration and... |
|
TMPY-04566
|
CAMKV Protein, Human, Recombinant (His & GST)
1G5,VACAMKL,CaM kinase-like vesicle-associated
|
Human
|
Baculovirus Insect Cells
|
|
CaM kinase-like vesicle-associated protein, also known as CAMKV, is a peripheral membrane protein and Cytoplasmic vesicle membrane protein which belongs to theprotein kinase superfamily and CAMK Ser/Thr protein kinase family. CAMKV contains oneprotein kinase domain. It is predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. CAMKV may be associated with vesicular structures. It does not appear to have detectable kinase activity. ... |
|
TMPK-01386
|
TK1 Potein, Canine, Recombinant (His)
thymidine kinase-1,EC 2.7.1.21,Thymidine kinase
|
Canine
|
E. coli
|
|
Thymidine kinase 1 (TK1) catalyzes the initial phosphorylation of thymidine in the salvage pathway synthesis of dTTP, an essential building block of DNA. TK1 is a cytosolic enzyme with its highest level during the S-phase of the cell cycle. |
|
TMPY-02002
|
PHPT1 Protein, Human, Recombinant (His)
phosphohistidine phosphatase 1,CGI-202,HSPC141,HEL-S-132P,PH...
|
Human
|
E. coli
|
|
PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to the janus family. PHPT1 / PHP14 is expressed abundantly in heart and skeletal muscle. Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. Protein histidin... |
|
TMPY-04445
|
PDK4 Protein, Mouse, Recombinant (His & GST)
AV005916,pyruvate dehydrogenase kinase 4
|
Mouse
|
Baculovirus Insect Cells
|
|
Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability.Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxida... |
|
TMPY-03507
|
PPC-DC Protein, Human, Recombinant (E. coli, His)
coaC,MDS018,PPC-DC,phosphopantothenoylcysteine decarboxylase
|
Human
|
E. coli
|
|
PPC-DC, also known as PPCDC, belongs to the HFCD (homo oligomeric flavin containing Cys decarboxylase) superfamily which takes a part in the biosynthesis of coenzyme A (CoA) from pantothenate (Vitamin B). Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. This process include several steps: the phosphorylation of pantothenate, the conversion of 4’-hosphopantothenate to 4''-phosphopantetheine, the adenylation by pho... |
|
TMPY-04073
|
MRPL44 Protein, Human, Recombinant (His)
mitochondrial ribosomal protein L44,COXPD16,L44MT,MRP-L44
|
Human
|
Baculovirus Insect Cells
|
|
MRPL44 (Mitochondrial Ribosomal Protein L44) is a Protein Coding gene. MRPL44 encodes a protein in the large subunit of the mitochondrial ribosome and is suggested to locate near the tunnel exit of the yeast mitochondrial ribosome. It belongs to the mitochondrion-specific ribosomal protein mL44 subfamily. In the patient fibroblasts, decreased MRPL44 affected assembly of the large ribosomal subunit and stability of 16S rRNA leading to complex IV deficiency. It may have a function in the assembly/... |
|
TMPH-02267
|
AGTRAP Protein, Human, Recombinant (His & Myc & SUMO)
ATRAP,AT1 receptor-associated protein,Type-1 angiotensin II ...
|
Human
|
E. coli
|
|
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. |
|
TMPH-00726
|
Ribokinase Protein, E. coli, Recombinant (His)
Ribokinase,rbsK
|
E. coli
|
E. coli
|
|
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. |
|
TMPH-03021
|
PstP Protein, Mycobacterium tuberculosis, Recombinant (His)
Mycobacterial Ser/Thr phosphatase,PP2C-family Ser/Thr phosph...
|
Mycobacterium tuberculosis
|
E. coli
|
|
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling. May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell. Plays a role in establishing and maintaining infection. |
|
TMPH-03671
|
Vaccinia virus (strain Western Reserve) K3 Protein (His)
Protein K2,Protein K3
|
VACV
|
P. pastoris (Yeast)
|
|
Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain Western Reserve) K3 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 12.6 kDa and the accession number is P18378. |
|
TMPY-03442
|
MOB4A/MOB1B Protein, Human, Recombinant (GST)
MOB kinase activator 1B,MOBKL1A,MATS2,MOB4A
|
Human
|
E. coli
|
|
MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MO... |
|
TMPH-00422
|
Ppdk Protein, Clostridium symbiosum, Recombinant (His & Myc)
ppdK,Pyruvate, orthophosphate dikinase,Pyruvate, phosphate d...
|
Clostridium symbiosum
|
E. coli
|
|
Catalyzes the reversible phosphorylation of pyruvate and phosphate. In E.histolytica and C.symbiosus, PPDK functions in the direction of ATP synthesis. Ppdk Protein, Clostridium symbiosum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.5 kDa and the accession number is P22983. |
|
TMPK-01132
|
PRL-1/PTP4A1 Protein, Human, Recombinant (His)
PTPCAAX1,PRL1,PRL-1,PTP(CAAXI),PTP4A1
|
Human
|
E. coli
|
|
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PRL-1 (PTP4A1) is a key molecule that activates tyrosine phosphorylation, which is important for cancer progression and metastasis. |
|
TMPH-03194
|
GCK Protein, Pyrococcus horikoshii, Recombinant (His & Myc)
Glycerate 2-kinase,gck,2-phosphoglycerate forming glycerate ...
|
Pyrococcus horikoshii
|
E. coli
|
|
Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also utilize GTP, CTP, UTP, ADP or pyrophosphate as phosphate donor. GCK Protein, Pyrococcus horikoshii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.8 kDa and the accession number is O58231. |
|
TMPY-04137
|
ATP6V1F Protein, Human, Recombinant (GST)
Vma7,ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F,...
|
Human
|
E. coli
|
|
ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using reverse transcription polymerase chain reaction and touchdown-polymerase chain reaction, respectively. Topology prediction showed that there is one protein kinase C phosphorylation site, two Casein kinase II phosphorylation sites, and one N-myristoylation site in the ATP6V1F protein. U... |
|
TMPH-02855
|
PML Protein, Mouse, Recombinant (His & Myc)
Protein PML,Pml
|
Mouse
|
E. coli
|
|
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosp... |
|
TMPH-03672
|
Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO)
Protein K2,Protein K3
|
VACV
|
E. coli
|
|
Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 26.6 kDa and the accession number is P18378. |
|
TMPJ-00218
|
SLAMF6 Protein, Human, Recombinant (His & Avi), Biotinylated
CD352,SLAM Family Member 6,Activating NK Receptor,NTB-A,KALI...
|
Human
|
HEK293 Cells
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SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Pho... |
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TMPJ-00978
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PIP4K2A Protein, Human, Recombinant (His)
Diphosphoinositide kinase 2-α,PtdIns(5)P-4-kinase isoform 2-...
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Human
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HEK293 Cells
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Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the... |
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TMPH-03670
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Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO)
Protein K3,OPG041
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VACV
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E. coli
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Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 26.5 kDa and the accession number is P20639. |
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