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PD0325901-O-C2-dioxolane的主体为PD0325901,PD0325901是一种典型的非ATP竞争性MEK1/2(丝裂原活化蛋白激酶)抑制剂,占据ATP结合位点附近的变构结合袋,具有减少ERK的磷酸化和抑制细胞增殖的抗癌作用。
PD0325901-O-C2-dioxolane的主体为PD0325901,PD0325901是一种典型的非ATP竞争性MEK1/2(丝裂原活化蛋白激酶)抑制剂,占据ATP结合位点附近的变构结合袋,具有减少ERK的磷酸化和抑制细胞增殖的抗癌作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,080 | 5日内发货 | |
5 mg | ¥ 2,100 | 5日内发货 |
产品描述 | The main body of PD0325901-O-C2-dioxolane is PD0325901, which is a typical non-ATP-competitive MEK1/2 (mitogen-activated protein kinase) inhibitor occupying a variant-binding pocket near the ATP-binding site, with anticancer effects of decreasing ERK phosphorylation and inhibiting cell proliferation. |
体外活性 | PD0325901 is a non-ATP competitive MEK inhibitor, potently inhibits ERK signaling and proliferation of tumor cells[1]. |
分子量 | 508.23 |
分子式 | C18H16F3IN2O4 |
CAS No. | 2581116-22-3 |
Smiles | O=C(NOCCC1OCCO1)C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F |
存储 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 80 mg/mL (157.41 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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