Okadaic acid ammonium salt

Name: Okadaic acid ammonium salt
Brand: TargetMol
SKU: T39183
Rating: 4.5 (1 reviews)

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产品编号 T39183Cas号 175522-42-6

别名 冈田酸铵盐

Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50 =3.7-4 nM), PP4 (IC 50 =0.1 nM), and PP5 (IC 50 =3.5 nM), but does not affect PP2C. By inhibiting PPs, this compound promotes protein phosphorylation and acts as a tumor promoter. Additionally, it is involved in inducing tau phosphorylation.

Okadaic acid ammonium salt

还可以

产品编号 T39183 别名 冈田酸铵盐Cas号 175522-42-6

规格	价格	库存	数量
25 mg	¥ 10,600	期货

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生物活性

产品描述	Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50 =3.7-4 nM), PP4 (IC 50 =0.1 nM), and PP5 (IC 50 =3.5 nM), but does not affect PP2C. By inhibiting PPs, this compound promotes protein phosphorylation and acts as a tumor promoter. Additionally, it is involved in inducing tau phosphorylation.
靶点活性	PP1:15-50 nM (IC50), PP4:0.1 nM (IC50), PP3:3.7-4 nM (IC50), PP2B:4000 nM (IC50), PP5:3.5 nM (IC50), PP2A:0.1-0.3 nM (IC50), PP7:＞1000 nM (IC50)
体外活性	Okadaic acid ammonium salt (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3]. Okadaic acid (10 nM, 8 hours) ammonium salt increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4]. Cell Proliferation Assay[3]Cell Line: AGS, MNK-45 and Caco 2 cell lines Concentration: 0-100 nM Incubation Time: 24 h or 48 h Result: Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.
体内活性	Okadaic acid ammonium salt (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5]. Animal Model: Female wild-type C57BL/6 mice (6 to 8 months)[5]Dosage: 100 μM Administration: Injected unilaterally to the lateral amygdala Result: Induced Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection.
别名	冈田酸铵盐