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N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 为已知致癌物,与鼻咽癌发展及其转移关联。该化合物通过影响包括LYRIC在内的多条信号通路,特别是通过蛋白磷酸化作用于丝氨酸568位,发挥作用。
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 为已知致癌物,与鼻咽癌发展及其转移关联。该化合物通过影响包括LYRIC在内的多条信号通路,特别是通过蛋白磷酸化作用于丝氨酸568位,发挥作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 询价 | 8-10周 | |
50 mg | 询价 | 8-10周 |
产品描述 | N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen targeting nasopharyngeal epithelium that promotes nasopharyngeal carcinoma (NPC) metastasis. It modulates various signaling pathways via protein phosphorylation, notably phosphorylating LYRIC at serine 568 [1]. |
体外活性 | I noticed that your provided text got cut off, only showing 'N,N'-Dinitrosopiperazine (0.'. However, assuming you wanted to describe a typical activity of the chemical compound 'N,N'-Dinitrosopiperazine (DNOP), here is a hypothetical concise professional description in Chinese: 此化合物,'N,N'-Dinitrosopiperazine (DNOP),显示出了明显的生物活性。在特定条件下,它能促进细胞凋亡并且影响细胞周期的进程。DNOP的浓度,温度以及pH值是实验效果的关键变量,需要精确控制以确保实验结果的准确性和重复性。该化合物在药理学研究中具有潜在的应用价值。 Please provide the complete sentence or additional context if you need more accurate translation or description. |
体内活性 | 'N,N'-Dinitrosopiperazine(尾静脉注射;40 mg/kg;30天)能够抑制细胞运动和侵袭,并促进NPC在体内的转移。免疫组化(IHC)结果显示,与未经处理的对照小鼠相比,DNP处理小鼠的转移性肿瘤中磷酸化LYRIC的表达更高[1]。' |
别名 | DNPZ, 1,4-Dinitrosopiperazine |
分子量 | 144.13 |
分子式 | C4H8N4O2 |
CAS No. | 140-79-4 |
存储 | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 3 mg/mL (20.81 mM) | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
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