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Apoptin-derived peptide, an antitumor polypeptide, exhibits cytotoxic effects by promoting apoptosis and necrosis in gastric cancer (GC) cells through the modulation of the PI3K / AKT / ARNT signaling pathway. It also impedes both the invasion and migration of cancer cells by inhibiting the expression and phosphorylation of the p85 subunit of PI3K, subsequently suppressing the PI3K / AKT pathway critical to gastric cancer development [1].
Apoptin-derived peptide, an antitumor polypeptide, exhibits cytotoxic effects by promoting apoptosis and necrosis in gastric cancer (GC) cells through the modulation of the PI3K / AKT / ARNT signaling pathway. It also impedes both the invasion and migration of cancer cells by inhibiting the expression and phosphorylation of the p85 subunit of PI3K, subsequently suppressing the PI3K / AKT pathway critical to gastric cancer development [1].
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 待询 | |
50 mg | 询价 | 待询 |
产品描述 | Apoptin-derived peptide, an antitumor polypeptide, exhibits cytotoxic effects by promoting apoptosis and necrosis in gastric cancer (GC) cells through the modulation of the PI3K / AKT / ARNT signaling pathway. It also impedes both the invasion and migration of cancer cells by inhibiting the expression and phosphorylation of the p85 subunit of PI3K, subsequently suppressing the PI3K / AKT pathway critical to gastric cancer development [1]. |
体外活性 | Apoptin-derived peptide (10-100 μg/mL, 4-24 h) 通过抑制 PI3K/AKT 信号通路,在 SGC-7901/CDDP 细胞中逆转耐药性并增加其对 CDDP 的敏感性,同时明显降低 p85 (p-p85) 和 AKT (p-AKT) 的磷酸化,还降低了 MDR1 和 ARNT 的表达。在 SGC-7901、SGC-7901/CDDP 及 MGC-803 细胞中,Apoptin-derived peptide 在浓度依赖下显著抑制细胞迁移和侵袭。通过 Cell Viability Assay、Apoptosis Analysis 和 Cell Cycle Analysis 展示其对胃癌细胞的有效抑制作用,尤其是在 SGC-7901/CDDP 细胞中表现出强烈的时间和剂量依赖性诱导凋亡。Western Blot Analysis 在 40-100 μg/mL 浓度下显著下降 p85 和 AKT 活性。 |
分子量 | 5177.33 |
分子式 | C223H417N89O50S |
CAS No. | 2232156-31-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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