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Targets Recommended: Angiotensin-converting Enzyme (ACE) E1/E2/E3 Enzyme Others

1175

抑制剂 & 化合物

178

天然产物

10

化合物库

489

重组蛋白

23

同位素标记化合物

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Cat. No. Product Name
L2200 酪氨酸激酶分子库

1016 compounds
1016 种酪氨酸激酶抑制剂的独特集合,可用于高通量筛选和高内涵筛选;
L8600 泛素化化合物库

210 compounds
210 种泛素化相关的小分子,用于高通量和高内涵筛选;
L1120 AMPK靶向分子库

80 compounds
80 个靶向AMPK 的分子集合,可用于高通量和高内涵筛选;
L2900 氧化还原化合物库

1264 compounds
1264 个活性化合物,已经验证具有一定的抗氧化活性,包括 ROS 清除剂、iNOS、eNOS、及抗氧化的天然产物,是研究疾病机理以及药物研究的优良载体
L3500 组蛋白修饰化合物库

469 compounds
469 个组蛋白修饰相关的小分子化合物的特有集合,用于高通量、高内涵筛选;
L1600 激酶抑制剂库

2720 compounds
2720 种激酶抑制剂/调节剂的独特集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选;
L8500 HIF-1化合物库

1336 compounds
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究;
L7110 抗高血压化合物库

678 compounds
678 种高血压相关的小分子,用于高通量和高内涵筛选;
L3800 NF-κB 通路分子库

729 compounds
729 个 NF-κB 信号通路相关的小分子化合物的特有集合,用于高通量、高内涵筛选;
L2550 谷氨酰胺代谢化合物库

565 compounds
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选;

化合物库

酪氨酸激酶分子库
Cat.No: L2200
Compounds: 1016
泛素化化合物库
Cat.No: L8600
Compounds: 210
AMPK靶向分子库
Cat.No: L1120
Compounds: 80
氧化还原化合物库
Cat.No: L2900
Compounds: 1264
组蛋白修饰化合物库
Cat.No: L3500
Compounds: 469
激酶抑制剂库
Cat.No: L1600
Compounds: 2720
HIF-1化合物库
Cat.No: L8500
Compounds: 1336
抗高血压化合物库
Cat.No: L7110
Compounds: 678
NF-κB 通路分子库
Cat.No: L3800
Compounds: 729
谷氨酰胺代谢化合物库
Cat.No: L2550
Compounds: 565
Cat. No. Product Name Target Signaling Pathways
T11940 Malic enzyme inhibitor ME1

ME1

Others Others
Malic enzyme inhibitor ME1 (ME1) 是苹果酸酶的特异性抑制剂 (IC50 = 0.15 μM)。 苹果酸酶抑制剂 ME1 降低细胞活力/代谢活性。
T76169 Angiotensin-converting enzyme

Angiotensin-converting enzyme (ACE)血管紧张素转换酶是一种二羧基肽酶,它将非活性的血管紧张素 I (Ang I) 转化为活性的 Ang II,并降解活性的缓激肽 (BK)。Angiotensin-converting enzyme 是一种有效的血管收缩剂,常用于生化研究。
T79450 Enzyme-IN-2

Others Others
Enzyme-IN-2(化合物 15),作为ureases抑制剂,展现出了强效的抗尿素分解活性,其Ki值为2.36 μM,而IC50值为0.75 µM。
T74878 Enzyme-IN-1

Others Others
Enzyme-IN-1(compound 1)为基于肽的N端亲核试剂(Ntn)水解酶抑制剂,特别针对20S蛋白酶体的糜胰蛋白酶样活性(CT-L)进行抑制,可能展现出抗炎特性。
T24136 Heclin

E1/E2/E3 Enzyme Ubiquitination
Heclin 是一种 HECT E3 泛素连接酶抑制剂,通过抑制 Smurf2、Nedd4 和 WWP1 起作用,IC50 值分别为 6.8、6.3 和 6.9 μM。
T16102 ML-792

E1/E2/E3 Enzyme Ubiquitination
ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2,IC50分别为 3 和 11 nM,对 NAE/NEDD8 和 UAE/ubiquitin 抑制作用微弱,IC50分别为 32 μM 和 >100 μM。
T12261 NSC232003

E1/E2/E3 Enzyme Ubiquitination
NSC232003 是高效的UHRF1抑制剂,能够抑制 DNA 甲基化,并破坏 DNMT1/UHRF1 相互作用。
T16901 SMIP004

Apoptosis; Others; E1/E2/E3 Enzyme Apoptosis; Others; Ubiquitination
SMIP004 是一种 SKP2 E3 连接酶抑制剂。 SMIP004 是人前列腺癌细胞的癌细胞特异性凋亡诱导剂。
T2158 Nutlin-3

Nutlin3

E1/E2/E3 Enzyme Ubiquitination
Nutlin-3 是一种 MDM2 拮抗剂,抑制 MDM2-p53 相互作用 ,Ki 为 90 nM,并激活 p53。
T5374 NAcM-OPT

E1/E2/E3 Enzyme; NEDD8 Metabolism; Ubiquitination
NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂,可以抑制 DCN1-UBE2M 相互作用。
T16888 SJ-172550

Mdm2; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
SJ-172550 是 MDMX 的小分子抑制剂,EC50为5 μM。
T5199 COH000

E1/E2/E3 Enzyme Ubiquitination
COH000 是不可逆的泛素样激活酶1 共价变构抑制剂,体外测得对 SUMO 化修饰的IC50=0.2 μM。
T16699 PYZD-4409

Others; E1/E2/E3 Enzyme Others; Ubiquitination
PYZD-4409 是一种特异性 UBA1 抑制剂,IC50 为 20 μM。 PYZD-4409 在恶性细胞中诱导细胞死亡,并且对恶性细胞的细胞毒性优于对正常造血细胞的细胞毒性。
T8428 Subasumstat

TAK-981

E1/E2/E3 Enzyme Ubiquitination
Subasumstat (TAK-981) 是SUMOylation 酶联反应的选择性抑制剂,具有潜在的免疫激活和抗肿瘤特性。
T7379 2-D08

E1/E2/E3 Enzyme; TAM Receptor Tyrosine Kinase/Adaptors; Ubiquitination
2-D08是小泛素样修饰蛋白抑制剂。2-D08也能抑制 Axl,IC50=0.49 nM。
T7415 DKM 2-93

E1/E2/E3 Enzyme Ubiquitination
DKM 2-93是相对选择性 UBA5抑制剂,IC50=430 μM。
T9236 WSB1 Degrader 1

Others; E1/E2/E3 Enzyme Others; Ubiquitination
WSB1 Degrader 1 是具有口服活性的 WSB1降解剂,具有抗癌活性。
T13244 Ubiquitination-IN-1

Others Others
Ubiquitination-IN-1 是一种有效的泛素化和Cksl-Skp2蛋白互作抑制剂 (IC50=0.17 μM) 抑制剂,增加 p27 水平,可通过阻断肿瘤抑制因子的降解发挥作用。
T7889 C25-140

Others; TNF; E1/E2/E3 Enzyme; NF-κB Apoptosis; NF-κB; Others; Ubiquitination
C25-140 是一种具有口服活性和一定选择性的 TRAF6-Ubc13相互作用抑制剂。它直接与 TRAF6 结合,阻断 TRAF6 和 Ubc13 的相互作用,降低 TRAF6 和 NF-κB 的活性,并与自身免疫对抗。
T6629 PYR-41

PYR41,PYR 41

Apoptosis; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
PYR-41 是一种选择性,可透过细胞的泛素活化酶 E1抑制剂,IC50值小于10 μM。
T6149 YH239-EE

Apoptosis; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
YH239-EE 是 YH239 的乙酯,是 p53-MDM2 拮抗剂和凋亡诱导剂。
T3653 MX69

Mdm2; E1/E2/E3 Enzyme; IAP Apoptosis; Ubiquitination
MX69 是用于抗癌研究的一种MDM2/XIAP 抑制剂。
T10703 Mezigdomide

CC-92480

Apoptosis; E1/E2/E3 Enzyme; Molecular Glues Apoptosis; PROTAC; Ubiquitination
Mezigdomide (CC-92480) 是一种有效的、新型的、具有选择性的和具有活性的 cereblon E3 泛素连接酶调节剂 (CELMoD),常以分子胶的方式发挥作用。Mezigdomide 具有抗骨髓瘤活性。
T23371 SMER3

SMER 3

Others; Ligand for E3 Ligase Others; PROTAC
SMER3 是选择性的 Skp1-Cullin-F-box (SCF)Met30泛素连接酶抑制剂。SMER 3 通过抑制 SCFMet30来增强 Rapamycin 的生长抑制作用。
T3317 SZL P1-41

Apoptosis; Others; E1/E2/E3 Enzyme Apoptosis; Others; Ubiquitination
SZL P1-41 是 Skp2 抑制剂,可以阻止 Skp2-Skp1 复合物的组装。 它选择性地抑制 Skp2 SCF E3 连接酶活性,还在体内外抑制 Skp2 介导的 p27 和 Akt 泛素化。 它通过触发细胞衰老和抑制糖酵解来抑制 Y 细胞和 Y 干细胞的存活,有抗肿瘤作用。
T8564 BC-1382

Others; E1/E2/E3 Enzyme Others; Ubiquitination
BC-1382 是E3泛素连接酶HECTD2抑制剂,能够特异性破坏 HECTD2/PIAS1 相互作用 (IC50≈ 5 nM)。BC-1382具有抗炎活性。
T3517 RO8994

Mdm2; E1/E2/E3 Enzyme; p53 Apoptosis; Ubiquitination
RO8994是一种高效且特异性的螺吲哚酮小分子 MDM2 抑制剂,MTT 增殖试验和HTRF 结合试验的IC50 为 20 nM 和 5 nM。
T4253 Skp2 Inhibitor C1

SKPin C1

Others; E1/E2/E3 Enzyme Others; Ubiquitination
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1)是Skp2介导p27降解的特异性抑制剂。
T3110 PRT4165

NSC600157,PRT 4165

BMI-1; Others; E1/E2/E3 Enzyme Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others; Ubiquitination
PRT4165 (NSC600157) 是有效的 PRC1介导 H2A 泛素化的抑制剂。
T6254 Idasanutlin

RG7388,Ro 5503781,依达奴林

Mdm2; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
Idasanutlin (Ro 5503781) 是一种有效且特异性的 p53-MDM2 抑制剂 ,IC50值为 6 nM。
T13349 WS-383

E1/E2/E3 Enzyme Ubiquitination
WS-383 是高效、选择性、可逆的DCN1-UBC12相互作用抑制剂,IC50为11 nM。它抑制 Cul3/1 的类泛素化修饰,引起 NRF2,p21和p27 的积累。
T11980 MD-224

Mdm2; E1/E2/E3 Enzyme; PROTACs Apoptosis; PROTAC; Ubiquitination
MD-224是一种基于蛋白水解靶向嵌合体(PROTAC)概念的高效、高效的MDM2降解剂,是一类新型抗癌剂。
T5555 Siremadlin

NVP-HDM 201

E1/E2/E3 Enzyme Ubiquitination
Siremadlin (NVP-HDM 201) 是一种有效的、可口服的、高度特异性的 p53-MDM2 相互作用抑制剂。
T16974 TAK-243

MLN7243

Apoptosis; E1/E2/E3 Enzyme; NF-κB Apoptosis; NF-κB; Ubiquitination
TAK-243 (MLN7243) 是一种泛素激活酶 UAE 的抑制剂 (IC50=1 nM),具有选择性。TAK-243 可阻断泛素结合,破坏单泛素信号传导以及整体蛋白质泛素化。TAK-243 具有抗肿瘤活性,可以促进细胞凋亡。
T6965 RG7112

RG-7112,RG 7112,RO5045337

Mdm2; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
RG7112 (RO5045337) 是一种口服生物可利用的选择性 p53-MDM2 抑制剂。
T2243 Serdemetan

JNJ-26854165,N-[2-(1H-吲哚-3-基)乙基]-N'-(4-吡啶基)-1,4-苯二胺

Apoptosis; Mdm2; E1/E2/E3 Enzyme; p53 Apoptosis; Ubiquitination
Serdemetan (JNJ-26854165) 是一种 HDM2泛素连接酶拮抗剂,能诱导 p53野生型细胞的早期凋亡。
T3549 Avadomide

CC 122

Apoptosis; E1/E2/E3 Enzyme; Ligand for E3 Ligase Apoptosis; PROTAC; Ubiquitination
Avadomide (CC 122) 是口服有效的cereblon 调节剂,可以调节 cereblon E3 连接酶活性,诱导弥漫性大 B 细胞淋巴瘤细胞凋亡,具有抗肿瘤和免疫调节活性。
TQ0231 NVP-CGM097

CGM097

Mdm2; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
NVP-CGM097 (CGM097) 是一种选择性MDM2抑制剂,对hMDM2的IC50为 1.7 nM。
T1493 BH3I-1

BHI1

BCL; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
BH3I-1 (BHI1) 是一种Bcl-2家族拮抗剂,作用于p53/mDM2,Kd 为 5.3 μM。它抑制BakBH3 肽与Bcl-xL 结合,Ki 为 2.6 μM。
T6611 NSC697923

2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

E1/E2/E3 Enzyme Ubiquitination
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage ...
T25465 GS143

GS-143,GS 143

IκB/IKK; E1/E2/E3 Enzyme; NF-κB NF-κB; Ubiquitination
GS-143 是选择性的IκBα泛素化抑制剂,抑制 SCFβTrCP1介导的IκBα泛素化作用,IC50=5.2 μM。GS143 抑制NF-κB 的活化和靶基因的转录,并且不抑制蛋白酶体的特性,并具有抗哮喘作用。
TQ0127 Navtemadlin

AMG232,CS-1300

Mdm2; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
Navtemadlin (AMG232) 是一种有效的、选择性的、可口服的 p53-MDM2 相互作用抑制剂,IC50值为 0.6 nM。它以 0.045 nM 的 Kd 与 MDM2 结合。
T6023 Nutlin-3a

(-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3

Apoptosis; E1/E2/E3 Enzyme; Autophagy Apoptosis; Autophagy; Ubiquitination
Nutlin-3a ((−)-Nutlin-3) 是 Nutlin-3 的活性对映体,是一种 MDM2抑制剂,可抑制 MDM2-p53相互作用,稳定 p53 蛋白,从而诱导细胞自噬和凋亡,有潜力研究 TP53野生型卵巢癌。
T6585 SAR405838

MI773,MI 773,MI-77301,MI-773

Mdm2; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
SAR405838 (MI 773) 是 MI-773 的类似物,具有抗肿瘤活性。它是一种高效、选择性的MDM2-p53相互作用抑制剂,与 MDM2 结合的Ki 值为 0.88 nM。
T8929 BC1618

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

Mitophagy; Others; E1/E2/E3 Enzyme; AMPK Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling; Ubiquitination
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) 是一种具有口服活性的 Fbxo48 抑制剂,可刺激 Ampk 依赖性信号传导。它促进线粒体分裂,促进自噬并提高肝脏胰岛素敏感性。
T6614 Nutlin-3b

(+)-Nutlin-3,4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮

Mdm2; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
Nutlin-3b ((+)-Nutlin-3) 是一种 p53/MDM2 拮抗剂或抑制剂,IC50为 13.6 μM。它与 MDM2 的结合活性比 Nutlin-3a 低 150 倍。
T15082 DDAO

Others Others
DDAO 是有潜在用途的近红外红色荧光探针,其激发波长 (600-650 nm) 和长发射波长 (λem = 656 nm)可以调节。它可用于不同酶活性的检测,如 β-半乳糖苷酶,羧酸酯酶 2,硫酸酯酶,蛋白质磷酸酶 2A,人白蛋白和酯酶。
T7510 Leucylarginylproline

RAAS Endocrinology/Hormones
Leucylarginylproline 是一种血管紧张素转换酶抑制剂,IC50=为0.27μM。
T1484 Perindoprilat

Perindoprilate,培哚普利

RAAS; MRP; AChR Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
Perindoprilat (Perindoprilate) 是一种血管紧张素转换酶抑制剂。
T77778 KP-457

TNF‐α‐converting enzyme

Others Others
KP-457(TNF-α-转化酶)为ADAM17的选择性抑制剂,无细胞试验中IC50值为11.1 nM/L。该化合物亦能裁剪多种分子,包括GPIbα、GPV及TNF-α。

化合物

Malic enzyme inhibitor ME1
Cat.No: T11940
Synonym: ME1
Target: Others
Angiotensin-converting enzyme
Cat.No: T76169
Synonym:
Target:
Enzyme-IN-2
Cat.No: T79450
Synonym:
Target: Others
Enzyme-IN-1
Cat.No: T74878
Synonym:
Target: Others
Heclin
Cat.No: T24136
Synonym:
Target: E1/E2/E3 Enzyme
ML-792
Cat.No: T16102
Synonym:
Target: E1/E2/E3 Enzyme
NSC232003
Cat.No: T12261
Synonym:
Target: E1/E2/E3 Enzyme
SMIP004
Cat.No: T16901
Synonym:
Target: Apoptosis, Others, E1/E2/E3 Enzyme
Nutlin-3
Cat.No: T2158
Synonym: Nutlin3
Target: E1/E2/E3 Enzyme
NAcM-OPT
Cat.No: T5374
Synonym:
Target: E1/E2/E3 Enzyme, NEDD8
SJ-172550
Cat.No: T16888
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme
COH000
Cat.No: T5199
Synonym:
Target: E1/E2/E3 Enzyme
PYZD-4409
Cat.No: T16699
Synonym:
Target: Others, E1/E2/E3 Enzyme
Subasumstat
Cat.No: T8428
Synonym: TAK-981
Target: E1/E2/E3 Enzyme
2-D08
Cat.No: T7379
Synonym:
Target: E1/E2/E3 Enzyme, TAM Receptor
DKM 2-93
Cat.No: T7415
Synonym:
Target: E1/E2/E3 Enzyme
WSB1 Degrader 1
Cat.No: T9236
Synonym:
Target: Others, E1/E2/E3 Enzyme
Ubiquitination-IN-1
Cat.No: T13244
Synonym:
Target: Others
C25-140
Cat.No: T7889
Synonym:
Target: Others, TNF, E1/E2/E3 Enzyme, NF-κB
PYR-41
Cat.No: T6629
Synonym: PYR41,PYR 41
Target: Apoptosis, E1/E2/E3 Enzyme
YH239-EE
Cat.No: T6149
Synonym:
Target: Apoptosis, E1/E2/E3 Enzyme
MX69
Cat.No: T3653
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, IAP
Mezigdomide
Cat.No: T10703
Synonym: CC-92480
Target: Apoptosis, E1/E2/E3 Enzyme, Molecular Glues
SMER3
Cat.No: T23371
Synonym: SMER 3
Target: Others, Ligand for E3 Ligase
SZL P1-41
Cat.No: T3317
Synonym:
Target: Apoptosis, Others, E1/E2/E3 Enzyme
BC-1382
Cat.No: T8564
Synonym:
Target: Others, E1/E2/E3 Enzyme
RO8994
Cat.No: T3517
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, p53
Skp2 Inhibitor C1
Cat.No: T4253
Synonym: SKPin C1
Target: Others, E1/E2/E3 Enzyme
PRT4165
Cat.No: T3110
Synonym: NSC600157,PRT 4165
Target: BMI-1, Others, E1/E2/E3 Enzyme
Idasanutlin
Cat.No: T6254
Synonym: RG7388,Ro 5503781,依达奴林
Target: Mdm2, E1/E2/E3 Enzyme
WS-383
Cat.No: T13349
Synonym:
Target: E1/E2/E3 Enzyme
MD-224
Cat.No: T11980
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, PROTACs
Siremadlin
Cat.No: T5555
Synonym: NVP-HDM 201
Target: E1/E2/E3 Enzyme
TAK-243
Cat.No: T16974
Synonym: MLN7243
Target: Apoptosis, E1/E2/E3 Enzyme, NF-κB
RG7112
Cat.No: T6965
Synonym: RG-7112,RG 7112,RO5045337
Target: Mdm2, E1/E2/E3 Enzyme
Serdemetan
Cat.No: T2243
Synonym: JNJ-26854165,N-[2-(1H-吲哚-3-基)乙基]-N'-(4-吡啶基)-1,4-苯二胺
Target: Apoptosis, Mdm2, E1/E2/E3 Enzyme, p53
Avadomide
Cat.No: T3549
Synonym: CC 122
Target: Apoptosis, E1/E2/E3 Enzyme, Ligand for E3 Ligase
NVP-CGM097
Cat.No: TQ0231
Synonym: CGM097
Target: Mdm2, E1/E2/E3 Enzyme
BH3I-1
Cat.No: T1493
Synonym: BHI1
Target: BCL, E1/E2/E3 Enzyme
NSC697923
Cat.No: T6611
Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
Target: E1/E2/E3 Enzyme
GS143
Cat.No: T25465
Synonym: GS-143,GS 143
Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB
Navtemadlin
Cat.No: TQ0127
Synonym: AMG232,CS-1300
Target: Mdm2, E1/E2/E3 Enzyme
Nutlin-3a
Cat.No: T6023
Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3
Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy
SAR405838
Cat.No: T6585
Synonym: MI773,MI 773,MI-77301,MI-773
Target: Mdm2, E1/E2/E3 Enzyme
BC1618
Cat.No: T8929
Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK
Nutlin-3b
Cat.No: T6614
Synonym: (+)-Nutlin-3,4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮
Target: Mdm2, E1/E2/E3 Enzyme
DDAO
Cat.No: T15082
Synonym:
Target: Others
Leucylarginylproline
Cat.No: T7510
Synonym:
Target: RAAS
Perindoprilat
Cat.No: T1484
Synonym: Perindoprilate,培哚普利
Target: RAAS, MRP, AChR
KP-457
Cat.No: T77778
Synonym: TNF‐α‐converting enzyme
Target: Others
Cat. No. Product Name Target Signaling Pathways
T4S0181 Hinokiflavone

日本扁柏黄酮,扁柏双黄酮

MMP; BCL; E1/E2/E3 Enzyme Apoptosis; Proteases/Proteasome; Ubiquitination
Hinokiflavone 是pre-mRNA 剪接活性的新型调节剂,通过抑制剪接体装配来阻止pre-mRNA 底物的剪接,特别是阻止 B complex 的形成。它是SUMO protease 蛋白酶抑制剂,能够抑制前哨蛋白特异性蛋白酶 1 的活性。
T9352 hydrocotarnine

Others Others
hydrocotarnine 是 Cbl 的抑制剂。
T4036 Solasodine

Solancarpidine,Purapuridine,澳洲茄铵,Solasodin

Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal Apoptosis; Microbiology/Virology; Others; Ubiquitination
Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。
T6S2123 Ginkgolic Acid

Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1

Others; E1/E2/E3 Enzyme Others; Ubiquitination
Ginkgolic Acid (Romanicardic acid) 是一种天然化合物, 在体外实验中抑制SUMOylation,IC50=3.0 μM。
T2947 Indole-3-carbinol

吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol

E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53 Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination
Indole-3-carbinol (I3C) 是樟子松中的一种天然产物,是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂,可抑制 NF-κB 和 IκBα 激酶活化。
T1136 Amylase

Diastase,淀粉酶

Others Others
Amylase (Diastase) 是由胰腺和唾液腺分泌得到的一种酶,能够将淀粉水解为糖类。它大致可分为 α 亚型、 β 亚型 和 γ 亚型三种亚型。
T35951 Alkaline Phosphatase

Others Others
Alkaline phosphatase 是一种膜结合糖蛋白,在碱性条件下可催化磷酸单酯的水解。它可用于分子生物学和酶免分析。
T5S0106 Peimisine

贝母辛,Ebeiensine

RAAS; AChR Endocrinology/Hormones; Neuroscience
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。
T13299 Vicenin 3

维采宁-3,维采宁 3

RAAS Endocrinology/Hormones
Vicenin 3来源于广金钱草的地上部分。Vicenin 3是血管紧张素转换酶抑制剂,IC50=46.91 μM。
T8270 Deserpidine

地舍平,Harmonyl

RAAS Endocrinology/Hormones
Deserpidine (Harmonyl) 是从 Rauwolfia canescens 的根中分离的生物碱。Deserpidine 与 Reserpine 相关。Deserpidine 是竞争性血管紧张素转化酶抑制剂,可以被用作抗高血压药以及镇定剂。Deserpidine 还减少了肾上腺皮质血管紧张素 II 诱导的醛固酮分泌。
T4880 L-Dihydroorotic acid

Others; Endogenous Metabolite Metabolism; Others
L-Dihydroorotic acid 是一种能够通过二氢乳清酶,能够逆水解产生的无环 L-脲基琥珀酸。
T5796 Plantainoside D

Isoplantamajoside,车前草苷D

RAAS; PKC Chromatin/Epigenetic; Cytoskeletal Signaling; Endocrinology/Hormones
Plantainoside D (Isoplantamajoside) 可以抑制 ACE ,IC50=2.17 mM。Plantainoside D 也是IKK-β抑制剂。
T21418 Lisinopril

Linopril,赖诺普利,Zestril,Prinivil,Lisipril

RAAS Endocrinology/Hormones
Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂,能够作用于高血压,充血性心力衰竭和心脏病等。
T3851 Vicenin 2

Vicenin -2,维采宁 2,新西兰牡荆苷

RAAS Endocrinology/Hormones
Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂,IC50=43.83 μM。
T3753 Sinapinic Acid

Sinapic acid,芥子酸,Synapoic acid

Apoptosis; RAAS; Reactive Oxygen Species; HDAC Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类,是HDAC 抑制剂,对ACE-I 的活性也有抑制作用。它有抗肿瘤活性,诱导肿瘤细胞凋亡,具有抗氧化、抗糖尿病的作用。
T17143 Toyocamycin

丰加霉素,Vengicide

Apoptosis; Others; IRE1; Antibiotic; Antifungal Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50值为 80 nM。它还诱导凋亡。
T6627 Phosphoramidon Disodium

Phosphoramidon Disodium Salt,磷酰胺二钠

RAAS; Neprilysin; Others Endocrinology/Hormones; Metabolism; Others
Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂 。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ,中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ,0.034 和 78 μM。
T2796 Coenzyme Q10

Ubiquinone-10,辅酶Q10,CoQ10

Ferroptosis; Reactive Oxygen Species; Endogenous Metabolite Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
Coenzyme Q10 (CoQ10)是来自藤仓赤霉菌的一种天然产物,在线粒体呼吸链中充当电子载体。
T10857 Coenzyme A

Endogenous Metabolite Metabolism
Coenzyme A 是所有活细胞中必需的辅助因子,由泛酸,三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制,通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢,合成代谢途径和基因表达调控的关键参与者。
T5573 Coenzyme Q9

辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9

Apoptosis; Endogenous Metabolite Apoptosis; Metabolism
Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式,是电子传递链中的一种双亲分子组分,具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降,改善左心室功能,减少心肌梗死面积和心肌细胞凋亡。
T75699 Coenzyme Q6

Others Others
Coenzyme Q6 (Ubiquinone 30),一种异戊二烯化的苯醌脂质,主要在呼吸电子传输链中发挥作用,并作为脂质抗氧化剂,具备抗氧化性能,能够防止自由基生成和氧化损伤。
T5546 Helicin

绣线菊苷,Helecin

Others Others
Helicin 是一种发现于在蔷薇科中的syrB诱导剂。其中BglY 酶可水解 Helicin。
T19231 Cellulase

Others Others
Cellulase 是一种能够催化纤维素和其他碳水化合物水解的酶。
TMA1403 Cyclo(Ile-Ala)

Others Others
Cyclo(Ile-Ala) 是存在于海洋放线菌11014 I.中的天然产物,是细胞周期抑制剂。
T4781 N-Acetyl-L-phenylalanine

N-Ac-Phenylalanine,N-乙酰-L-苯丙氨酸

Others; Endogenous Metabolite Metabolism; Others
N-Acetyl-L-phenylalanine (N-Ac-Phenylalanine) 是一种大肠杆菌中的主要酰基氨基酸,由 L-苯丙氨酸和乙酰辅酶 A 合成。
T2S0663 Humantenmine

P450 Metabolism
Humantenmine 是一种分离自中国线虫中的生物碱,有用于疼痛和风湿性关节炎的研究潜力。
T3236 Solanesol

Betulanonaprenol,茄尼醇,Nonaisoprenol

Others; Endogenous Metabolite; Antibacterial Metabolism; Microbiology/Virology; Others
Solanesol (Betulanonaprenol) 是主要存在于茄科植物中的脂肪族萜烯醇,有抗炎、神经保护和抗菌活性。
TQ0190 D-Xylulose

Others; Endogenous Metabolite Metabolism; Others
D-xylulose 通过葡萄糖醛酸途径中的酶 NAD+ 连接的木糖醇脱氢酶从木糖醇转化,葡萄糖醛酸途径是哺乳动物中重要的木糖醇处理代谢途径。
T7873 Iberverin

Others Others
Iberverin 是一种天然产品。它诱导 II 期酶活性并降低前列腺癌细胞中雄激素受体的表达。
T4919 Ureidopropionic acid

Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid

Endogenous Metabolite Metabolism
Ureidopropionic acid (3-Ureidopropionic acid) 是尿嘧啶代谢的中间体。更具体地说,它是二氢尿嘧啶的分解产物,由二氢嘧啶酶产生。它通过β -脲丙酸酶进一步分解为β -丙氨酸。尿素丙酸本质上是β -丙氨酸的尿素衍生物。高水平的尿丙酸存在于β -尿丙酸酶(UP)缺乏的个体中。嘧啶代谢中的酶缺乏与抗肿瘤药物5-氟尿嘧啶的严重毒性风险有关。
T2S1434 Bergaptol

5-Hydroxyfuranocoumarin,4-Hydroxybergapten,5-羟基-6,7-呋喃并香豆素,5-Hydroxypsoralen

P450 Metabolism
Bergaptol (4-Hydroxybergapten) 是CYP3A4酶脱苄基作用的抑制剂(IC50:24.92 uM),具有抗癌、抗增殖作用。
T4755 2,3-Diaminopropanoic acid hydrochloride

DL-2,3-Diaminopropionic acid monohydroch,3-Amino-DL-alanine monohydrochloride,DL-2,3-二胺基丙酸盐酸盐

Others; Endogenous Metabolite Metabolism; Others
2,3-Diaminopropanoic acid hydrochloride (3-Amino-DL-alanine monohydrochloride) 是内源性代谢产物的一种。
T19357 Hyaluronidase

Hyaluronate 4-glycanohydrolase,Hyaluronoglucosaminidase,透明质酸酶

Others Others
Hyaluronidase (Hyaluronate 4-glycanohydrolase) 是一种天然存在的酶,能够分裂糖苷键,使透明质酸解聚。它可用于眼科手术。
T19615 α-Amylase

Amylase Metabolism
α-Amylase 是一种能够催化淀粉中 α-1,4-糖苷键水解的水解酶,使淀粉产生葡萄糖、麦芽糖等产物。
T5889 Kojic acid

Tyrosinase; Parasite Microbiology/Virology; Proteases/Proteasome
Kojic acid 是 Aspergillus oryzae 产生的一种真菌代谢物,用作抗氧化剂和防辐射剂,可抑制酪氨酸酶。
TN1058 Pelargonidin chloride

NOS; Reactive Oxygen Species; Nrf2; NO Synthase Immunology/Inflammation; Metabolism; NF-κB
Pelargonidin chloride 是一种氧化氮自由基的清除剂,具有抗氧化作用。
T3730 Methyl gallate

NSC 363001,Gallicin,Gallic acid methyl ester,Gallincin,没食子酸甲酯

Reactive Oxygen Species; HIV Protease; Reverse Transcriptase; Antibacterial Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
Methyl gallate (Gallincin) 是具有抗氧化,抗癌和抗炎活性的植物酚类。它也可抑制细菌活性。它还具有抗HIV-1和HIV-1酶的抑制活性。
TN7257 β-LactaMase

Antibiotic Microbiology/Virology
β-LactaMase 是细菌产生的酶,可水解青霉素类等抗生素,活性可被乙二胺四乙酸(EDTA)所抑制。
T4711 2,4-Dihydroxypyrimidine-5-carboxylic acid

脲嘧啶-5-羧酸,Isoorotic acid,Uracil-5-carboxylic acid

Others; Endogenous Metabolite Metabolism; Others
2,4-Dihydroxypyrimidine-5-carboxylic acid (Isoorotic acid) 是内源性代谢产物的一种。
T4719 1,4-D-Gulonolactone

D-Gulonic acid γ-lactone,D-(-)-古洛糖酸-1,4-内酯

Others; Endogenous Metabolite Metabolism; Others
1,4-D-Gulonolactone (D-Gulonic acid γ-lactone) (也称为还原性抗坏血酸,RAA) 是 L-gulono-1,4-lactone oxidoreductase (EC 1.1.3.8)的底物,催化植物和动物中l -抗坏血酸(维生素C)生物合成的最后一步。enzyme L-Gulono-1,4-lactone oxidase 在容易患坏血病、缺乏维生素c的动物(如人类)中缺失。1,4-D-Gulonolactone 存在于人体血液中,并被用作比较运动引起的氧化应激变化的标志物之一。
T2731 Usnic Acid

Usniacin,松萝酸,地衣酸

Antibacterial; Autophagy Autophagy; Microbiology/Virology
Usnic Acid (Usniacin) 是地衣次生代谢产物,具有独特的二苯并呋喃骨架。它是一种抗菌剂、抗肿瘤剂和酶抑制剂。
T5267 N-Acetyl-L-glutamic acid

Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid

Others; Endogenous Metabolite Metabolism; Others
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸,是动物细胞培养基的组成成分,是一种酿酒酵母和人类的代谢物。
T4924 α-D-Glucose-1-phosphate disodium

A-D-葡萄糖-1-磷酸-二钠盐,α-D-Glucose 1-phosphate disodium salt hy,α-D-Glucopyranose 1-phosphate

Others; Endogenous Metabolite Metabolism; Others
α-D-Glucose 1-phosphate disodium salt hydrate 是合成葡萄糖醛酸的起始原料。它可用作心脏病研究所必需的细胞抑制剂、抗生素、免疫抑制剂和循环系统研究材料。
T4887 3-Amino-2-methylpropanoic acid

DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine

Endogenous Metabolite Metabolism
3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) 是 N-carbamyl-beta-aminoisobutyric acid 经 enzyme Beta-ureidopropionase (EC 3.5.1.6)转化后的产物,是嘧啶降解的最后一步。-尿嘧啶丙酸酶缺乏症是一种与神经异常相关的嘧啶降解的先天性错误。
T37177 Norcholic Acid

Others Others
Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4
T19808 5-Bromo-5-nitro-1,3-dioxane

Bronidox,5-溴-5-硝基-1,3-二噁烷,5-溴-5-硝基-1,3-二恶烷

Others; Antibacterial; Antifungal Microbiology/Virology; Others
5-Bromo-5-nitro-1,3-dioxane (Bronidox) 是一种抗菌化合物,可通过必需蛋白硫醇的氧化抑制酶活性并随后抑制微生物的生长。它有抗革兰氏阳性和革兰氏阴性细菌,以及抗真菌活性。
T5755 Aloesin

Tyrosinase Proteases/Proteasome
Aloesin 是芦荟的活性成分之一,能够通过 MAPK 信号通路发挥抗癌作用,并具有抗炎、紫外线保护和抗菌作用。
T19229 Catalase

Others Others
Catalase 是重要的抗氧化酶,在清除 ROS 及维持氧化还原状态的平衡方面发挥着重要作用。Catalase 与肿瘤的发生,发展关系密切。有潜力用于肿瘤的预防研究。
T3016 D-(+)-Melezitose hydrate

D-Melezitose,melicitose,Melezitose,松三糖

Others; Antibacterial Microbiology/Virology; Others
D-(+)-Melezitose hydrate (melicitose) 是由许多以植物汁液为食的昆虫通过酶反应产生的一种非还原性三糖,能鉴定吲哚阳性和吲哚阴性克雷伯菌属的临床分离株。
T6S0923 Hypericin

Hypericine,金丝桃素,Cyclosan

Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
Hypericin (Cyclosan) 是贯叶连翘的提取物,有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
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天然产物

Hinokiflavone
Cat.No: T4S0181
Synonym: 日本扁柏黄酮,扁柏双黄酮
Target: MMP, BCL, E1/E2/E3 Enzyme
hydrocotarnine
Cat.No: T9352
Synonym:
Target: Others
Solasodine
Cat.No: T4036
Synonym: Solancarpidine,Purapuridine,澳洲茄铵,Solasodin
Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal
Ginkgolic Acid
Cat.No: T6S2123
Synonym: Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1
Target: Others, E1/E2/E3 Enzyme
Indole-3-carbinol
Cat.No: T2947
Synonym: 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol
Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53
Amylase
Cat.No: T1136
Synonym: Diastase,淀粉酶
Target: Others
Alkaline Phosphatase
Cat.No: T35951
Synonym:
Target: Others
Peimisine
Cat.No: T5S0106
Synonym: 贝母辛,Ebeiensine
Target: RAAS, AChR
Vicenin 3
Cat.No: T13299
Synonym: 维采宁-3,维采宁 3
Target: RAAS
Deserpidine
Cat.No: T8270
Synonym: 地舍平,Harmonyl
Target: RAAS
L-Dihydroorotic acid
Cat.No: T4880
Synonym:
Target: Others, Endogenous Metabolite
Plantainoside D
Cat.No: T5796
Synonym: Isoplantamajoside,车前草苷D
Target: RAAS, PKC
Lisinopril
Cat.No: T21418
Synonym: Linopril,赖诺普利,Zestril,Prinivil,Lisipril
Target: RAAS
Vicenin 2
Cat.No: T3851
Synonym: Vicenin -2,维采宁 2,新西兰牡荆苷
Target: RAAS
Sinapinic Acid
Cat.No: T3753
Synonym: Sinapic acid,芥子酸,Synapoic acid
Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC
Toyocamycin
Cat.No: T17143
Synonym: 丰加霉素,Vengicide
Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal
Phosphoramidon Disodium
Cat.No: T6627
Synonym: Phosphoramidon Disodium Salt,磷酰胺二钠
Target: RAAS, Neprilysin, Others
Coenzyme Q10
Cat.No: T2796
Synonym: Ubiquinone-10,辅酶Q10,CoQ10
Target: Ferroptosis, Reactive Oxygen Species, Endogenous Metabolite
Coenzyme A
Cat.No: T10857
Synonym:
Target: Endogenous Metabolite
Coenzyme Q9
Cat.No: T5573
Synonym: 辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9
Target: Apoptosis, Endogenous Metabolite
Coenzyme Q6
Cat.No: T75699
Synonym:
Target: Others
Helicin
Cat.No: T5546
Synonym: 绣线菊苷,Helecin
Target: Others
Cellulase
Cat.No: T19231
Synonym:
Target: Others
Cyclo(Ile-Ala)
Cat.No: TMA1403
Synonym:
Target: Others
N-Acetyl-L-phenylalanine
Cat.No: T4781
Synonym: N-Ac-Phenylalanine,N-乙酰-L-苯丙氨酸
Target: Others, Endogenous Metabolite
Humantenmine
Cat.No: T2S0663
Synonym:
Target: P450
Solanesol
Cat.No: T3236
Synonym: Betulanonaprenol,茄尼醇,Nonaisoprenol
Target: Others, Endogenous Metabolite, Antibacterial
D-Xylulose
Cat.No: TQ0190
Synonym:
Target: Others, Endogenous Metabolite
Iberverin
Cat.No: T7873
Synonym:
Target: Others
Ureidopropionic acid
Cat.No: T4919
Synonym: Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid
Target: Endogenous Metabolite
Bergaptol
Cat.No: T2S1434
Synonym: 5-Hydroxyfuranocoumarin,4-Hydroxybergapten,5-羟基-6,7-呋喃并香豆素,5-Hydroxypsoralen
Target: P450
2,3-Diaminopropanoic acid hydrochloride
Cat.No: T4755
Synonym: DL-2,3-Diaminopropionic acid monohydroch,3-Amino-DL-alanine monohydrochloride,DL-2,3-二胺基丙酸盐酸盐
Target: Others, Endogenous Metabolite
Hyaluronidase
Cat.No: T19357
Synonym: Hyaluronate 4-glycanohydrolase,Hyaluronoglucosaminidase,透明质酸酶
Target: Others
α-Amylase
Cat.No: T19615
Synonym:
Target: Amylase
Kojic acid
Cat.No: T5889
Synonym:
Target: Tyrosinase, Parasite
Pelargonidin chloride
Cat.No: TN1058
Synonym:
Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase
Methyl gallate
Cat.No: T3730
Synonym: NSC 363001,Gallicin,Gallic acid methyl ester,Gallincin,没食子酸甲酯
Target: Reactive Oxygen Species, HIV Protease, Reverse Transcriptase, Antibacterial
β-LactaMase
Cat.No: TN7257
Synonym:
Target: Antibiotic
2,4-Dihydroxypyrimidine-5-carboxylic acid
Cat.No: T4711
Synonym: 脲嘧啶-5-羧酸,Isoorotic acid,Uracil-5-carboxylic acid
Target: Others, Endogenous Metabolite
1,4-D-Gulonolactone
Cat.No: T4719
Synonym: D-Gulonic acid γ-lactone,D-(-)-古洛糖酸-1,4-内酯
Target: Others, Endogenous Metabolite
Usnic Acid
Cat.No: T2731
Synonym: Usniacin,松萝酸,地衣酸
Target: Antibacterial, Autophagy
N-Acetyl-L-glutamic acid
Cat.No: T5267
Synonym: Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid
Target: Others, Endogenous Metabolite
α-D-Glucose-1-phosphate disodium
Cat.No: T4924
Synonym: A-D-葡萄糖-1-磷酸-二钠盐,α-D-Glucose 1-phosphate disodium salt hy,α-D-Glucopyranose 1-phosphate
Target: Others, Endogenous Metabolite
3-Amino-2-methylpropanoic acid
Cat.No: T4887
Synonym: DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine
Target: Endogenous Metabolite
Norcholic Acid
Cat.No: T37177
Synonym:
Target: Others
5-Bromo-5-nitro-1,3-dioxane
Cat.No: T19808
Synonym: Bronidox,5-溴-5-硝基-1,3-二噁烷,5-溴-5-硝基-1,3-二恶烷
Target: Others, Antibacterial, Antifungal
Aloesin
Cat.No: T5755
Synonym:
Target: Tyrosinase
Catalase
Cat.No: T19229
Synonym:
Target: Others
D-(+)-Melezitose hydrate
Cat.No: T3016
Synonym: D-Melezitose,melicitose,Melezitose,松三糖
Target: Others, Antibacterial
Hypericin
Cat.No: T6S0923
Synonym: Hypericine,金丝桃素,Cyclosan
Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC
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Cat. No. Product Name Species Expression System
TMPH-00038 Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc)

Snake venom serine protease,Thrombin-like enzyme co...

Agkistrodon contortrix E. coli
Thrombin-like snake venom serine protease that cleaves beta chain of fibrinogen (FGB), releasing fibrinopeptide B. Has a coagulant activity activating blood coagulation factors V (F5) and XIII (F13A1). Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.4 kDa and the accession number is P82981.
TMPY-03441 SAE1 Protein, Human, Recombinant

SUA1,SUMO1 activating enzyme subunit 1,HSPC140,UBLE...

Human Baculovirus Insect Cells
SAE1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 38.6 kDa and the accession number is Q9UBE0.
TMPJ-01405 Kallikrein 5/KLK5 Protein, Human, Recombinant (His)

Stratum Corneum Tryptic Enzyme,Kallikrein-Like Prot...

Human HEK293 Cells
Kallikrein 5/KLK5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40 KDa and the accession number is Q9Y337.
TMPY-02840 Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)

UBE1,ubiquitin-like modifier activating enzyme 1,UB...

Human Baculovirus Insect Cells
UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It also catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation by first adenylating its C-terminal glycine residue w...
TMPY-02207 ACE2/ACEH Protein, Rat, Recombinant (His)

angiotensin I converting enzyme 2

Rat HEK293 Cells
ACE2/ACEH Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85 kDa and the accession number is Q5EGZ1.
TMPJ-01324 UBA5 Protein, Human, Recombinant (His)

Ubiquitin-like modifier-activating enzyme 5,UBE1DC1...

Human E. coli
UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy th...
TMPY-01838 ACE2/ACEH Protein, Mouse, Recombinant (His)

angiotensin I converting enzyme 2,2010305L05Rik

Mouse HEK293 Cells
ACE2/ACEH Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85 kDa and the accession number is Q8R0I0-1.
TMPH-01743 NADP-ME Protein, Human, Recombinant (His)

NADP-dependent malic enzyme, mitochondrial,ME3,Mali...

Human E. coli
NADP-ME Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 67.2 kDa and the accession number is Q16798.
TMPY-03561 ACE2/ACEH Protein, Rhesus, Recombinant (hFc)

angiotensin I converting enzyme 2

Rhesus HEK293 Cells
ACE2/ACEH Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110.7kDa and the accession number is B6DUF3.
TMPY-03830 ACE2/ACEH Protein, Rhesus, Recombinant (His)

angiotensin I converting enzyme 2

Rhesus HEK293 Cells
ACE2/ACEH Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.1 kDa and the accession number is B6DUF3.
TMPY-01839 ACE2/ACEH Protein, Mouse, Recombinant (His & hFc)

2010305L05Rik,angiotensin I converting enzyme 2

Mouse HEK293 Cells
ACE2/ACEH Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 112 kDa and the accession number is Q8R0I0-1.
TMPY-00678 BACE1 Protein, Mouse, Recombinant (His)

beta-site APP-cleaving enzyme 1,C76936,β-site APP-c...

Mouse HEK293 Cells
BACE1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.8 kDa and the accession number is P56818.
TMPH-03163 SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc)

Habutobin,Snake venom serine protease 1,Fibrinogen-clotting ...

Protobothrops flavoviridis E. coli
SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.1 kDa and the accession number is P05620.
TMPY-05725 ACE2/ACEH Protein, Human, Recombinant (His & Avi), Biotinylated

angiotensin I converting enzyme 2,ACEH

Human Baculovirus Insect Cells
ACE2/ACEH Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in Baculovirus insect cells with His and Avi tag. The predicted molecular weight is 86.86 kDa and the accession number is Q9BYF1-1.
TMPY-06334 ACE2/ACEH Protein, Human, Recombinant (hFc), Biotinylated

ACEH,angiotensin I converting enzyme 2

Human HEK293 Cells
ACE2/ACEH Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110.3 kDa and the accession number is NP_068576.1.
TMPY-00652 BACE1 Protein, Human, Recombinant

BACE,HSPC104,β-site APP-cleaving enzyme 1,beta-site...

Human HEK293 Cells
BACE1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 49 kDa and the accession number is A0A024R3D7.
TMPY-04312 ACE2/ACEH Protein, Human, Recombinant (mFc)

angiotensin I converting enzyme 2,ACEH

Human HEK293 Cells
ACE2/ACEH Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 110 kDa and the accession number is Q9BYF1-1.
TMPY-05266 ACE2/ACEH Protein, Human, Recombinant (His)

ACEH,angiotensin I converting enzyme 2

Human HEK293 Cells
ACE2/ACEH Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.1 kDa and the accession number is Q9BYF1-1.
TMPJ-01039 UBE2K Protein, Human, Recombinant (His & SUMO)

Ubiquitin-Conjugating Enzyme E2-25 kDa,Huntingtin-I...

Human E. coli
UBE2K Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis and SUMO tag. The predicted molecular weight is 38 KDa and the accession number is P61086.
TMPJ-00386 ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated

Metalloprotease MPROT15,ACEH,Angiotensin-Converting Enzy...

Human HEK293 Cells
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate...
TMPH-00324 SVTLE Protein, Calloselasma rhodostoma, Recombinant (His)

Thrombin-like enzyme ancrod,Snake venom serine prot...

Calloselasma rhodostoma P. pastoris (Yeast)
SVTLE Protein, Calloselasma rhodostoma, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 28.6 kDa and the accession number is P26324.
TMPY-00651 BACE1 Protein, Human, Recombinant (hFc)

HSPC104,β-site APP-cleaving enzyme 1,ASP2,beta-site...

Human HEK293 Cells
BACE1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75 kDa and the accession number is A0A024R3D7.
TMPY-00752 BACE1 Protein, Human, Recombinant (His)

β-site APP-cleaving enzyme 1,BACE,beta-site APP-cle...

Human HEK293 Cells
BACE1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.9 kDa and the accession number is A0A024R3D7.
TMPH-02288 UBE2D3 Protein, Human, Recombinant (His & SUMO)

(E3-independent) E2 ubiquitin-conjugating enzyme D3...

Human E. coli
UBE2D3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.7 kDa and the accession number is P61077.
TMPH-00768 SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc)

Calobin I,Snake venom serine protease,Fibrinogen-clotting

Gloydius ussuriensis E. coli
Thrombin-like snake venom serine protease. Has a coagulant activity. Acts on alpha-chains of fibrinogen (FGA) generating fibrinopeptide A. SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.7 kDa and the accession number is Q91053.
TMPY-02605 UBE2F Protein, Human, Recombinant (His)

ubiquitin-conjugating enzyme E2F (putative),NCE2

Human E. coli
UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d...
TMPY-05696 ACE2/ACEH Protein, Human, Recombinant (His), Biotinylated

ACEH,angiotensin I converting enzyme 2

Human HEK293 Cells
ACE2/ACEH Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.1 kDa and the accession number is Q9BYF1-1.
TMPY-00655 ACE2/ACEH Protein, Human, Recombinant (hFc)

angiotensin I converting enzyme 2,ACEH

Human HEK293 Cells
ACE2/ACEH Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110.3 kDa and the accession number is Q9BYF1-1.
TMPH-00108 UBC11 Protein, Arabidopsis thaliana, Recombinant (His)

Ubiquitin-conjugating enzyme E2-17 kDa 11,Ubiquitin...

Arabidopsis thaliana E. coli
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC11 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P35134.
TMPJ-01138 UBE2S Protein, Human, Recombinant (GST)

UBE2S,Ubiquitin-Conjugating Enzyme E2-24 kDa,E2-EPF...

Human E. coli
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiqui...
TMPY-01929 ECE1 Protein, Human, Recombinant (His)

RP3-329E20.1,endothelin converting enzyme 1,ECE

Human HEK293 Cells
Endothelin-converting enzyme 1, also known as ECE-1, is a single-pass type II membrane protein which belongs to thepeptidase M13 family. ECE-1 converts big endothelin-1 to endothelin-1. ECE-1 is a membrane metalloprotease that generates endothelin from its direct precursor big endothelin. Four isoforms of ECE-1 are produced from a single gene through the use of alternate promoters. These isoforms share the same extracellular catalytic domain and contain unique cytosolic tails, which resul...
TMPJ-01221 UBE2J2 Protein, Human, Recombinant (GST)

NCUBE-2,UBE2J2,Ubiquitin-Conjugating Enzyme E2 J2,N...

Human E. coli
Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalent attachment of ubiquitin to other proteins. UBE2J2 may play a important role in the selective degradation of misfolded membrane protein from the endoplasmic reticulum.
TMPY-02604 UBE2D4 Protein, Human, Recombinant (His)

HBUCE1,ubiquitin-conjugating enzyme E2D 4 (putative...

Human E. coli
UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To ...
TMPH-00215 SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc)

Venombin A,Fibrinogen-clotting enzyme,Snake venom s...

Bothrops jararaca E. coli
Thrombin-like snake venom serine protease that clots fibrinogen by releasing fibrinopeptide A from the alpha chain of fibrinogen (FGA), induces platelet aggregation through its interaction with GPIb (GP1BA/GP1BB), and activates factor VIII (F8). SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.0 kDa and the accession number is P81661.
TMPJ-00571 UBE2D3 Protein, Human, Recombinant

Ubiquitin-protein ligase D3,Ubiquitin-conjugating enzyme...

Human E. coli
UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.
TMPJ-01038 UBE2K Protein, Human, Recombinant (GST)

Ubiquitin-Conjugating Enzyme E2(25K),Ubiquitin Carr...

Human E. coli
UBE2K Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 45 KDa and the accession number is P61086.
TMPH-00395 Autolysin Protein, Chlamydomonas reinhardtii, Recombinant (His & SUMO)

Autolysin,GLE,Gametolysin,Gamete lytic enzyme

Chlamydomonas reinhardtii E. coli
Mediates digestion of the cell walls of the 2 mating type gametes during mating as a necessary prelude to cell fusion. This enzyme acts specifically on the framework proteins (inner wall) of the cell wall, cleaving several model peptides at specific sites. Autolysin Protein, Chlamydomonas reinhardtii, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.6 kDa and the accession number is P31178.
TMPY-02609 UBE2M Protein, Human, Recombinant

UBC12,UBC-RS2,ubiquitin-conjugating enzyme E2M,hUbc...

Human E. coli
UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d...
TMPH-00107 UBC10 Protein, Arabidopsis thaliana, Recombinant (His)

Ubiquitin carrier protein 10/12,Ubiquitin-conjugating en...

Arabidopsis thaliana E. coli
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC10 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P35133.
TMPH-00109 UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc)

E2 ubiquitin-conjugating enzyme 8,Ubiquitin carrier...

Arabidopsis thaliana E. coli
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.0 kDa and the accession number is P35131.
TMPY-01891 ECE2 Protein, Human, Recombinant (His)

endothelin converting enzyme 2,UNQ403/PRO740,KIAA06...

Human HEK293 Cells
ECE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.2 kDa and the accession number is P0DPD8.
TMPY-00782 ECE2 Protein, Human, Recombinant (hFc)

endothelin converting enzyme 2,KIAA0604,UNQ403/PRO7...

Human HEK293 Cells
ECE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 105 kDa and the accession number is P0DPD8.
TMPY-02642 UBE2W Protein, Human, Recombinant (His)

UBC16,UBC-16,ubiquitin-conjugating enzyme E2W (puta...

Human E. coli
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2W is a member of th...
TMPJ-01047 UBE2H Protein, Human, Recombinant (GST)

UBE2H,UbcH2,Ubiquitin-Conjugating Enzyme E2 H,Ubiqu...

Human E. coli
Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in ...
TMPY-02842 UBE2L6 Protein, Human, Recombinant (His)

UBCH8,ubiquitin-conjugating enzyme E2L 6,RIG-B

Human E. coli
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain. These domains accommodate the ATP-activated ubiquitin (Ub) or ubiquitin-like (UBL) protein via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the E1 and E3 enzymes and connect activation to covalent modi...
TMPY-02606 UBE2G1 Protein, Human, Recombinant

E217K,UBC7,ubiquitin-conjugating enzyme E2G 1,UBE2G

Human E. coli
UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To ...
TMPJ-01229 SUMF1 Protein, Human, Recombinant (His)

C-Alpha-Formylglycine-Generating Enzyme 1,FGE,C-α-F...

Human HEK293 Cells
Human Sulfatase Modifying Factor 1 (SUMF1) is a 42kDa protein. SUMF1 is a Ca2+-binging member of the sulfatase-modifying factor family. SUMF1 is a soluble ER lumenal glycoprotein, it converts inactive sulfatases into an active form by transforming a catalytic site cysteine into a formylglycine residue. In the ER, SUMF1 can exist as either a monomer, or a disulfide-linked homodimer or a heterodimer with SUMF2. Three splice isoforms are known.
TMPY-04263 UBE2T Protein, Human, Recombinant (His)

FANCT,PIG50,ubiquitin-conjugating enzyme E2T,HSPC15...

Human E. coli
Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers, representing an attractive target for the development of inhibitors. Notably, UBE2T locates at 1q32.1, and the gain of 1q is frequently observed in a variety of cancers. For instance, UBE2T serves an important role in the growth of bladder cancer cells, and may be considered as a potential biomarker and therapeutic target for bladder cancer.
TMPY-02608 UBC9/UBE2I Protein, Human, Recombinant

UBC9,ubiquitin-conjugating enzyme E2I,C358B7.1,P18

Human E. coli
UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d...
TMPH-02245 HADHB Protein, Human, Recombinant (GST)

HADHB,TP-beta,Trifunctional enzyme subunit beta, mi...

Human E. coli
Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex compo...
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重组蛋白

Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc)
Cat.No: TMPH-00038
Species: Agkistrodon contortrix
Expression System: E. coli
SAE1 Protein, Human, Recombinant
Cat.No: TMPY-03441
Species: Human
Expression System: Baculovirus Insect Cells
Kallikrein 5/KLK5 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01405
Species: Human
Expression System: HEK293 Cells
Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-02840
Species: Human
Expression System: Baculovirus Insect Cells
ACE2/ACEH Protein, Rat, Recombinant (His)
Cat.No: TMPY-02207
Species: Rat
Expression System: HEK293 Cells
UBA5 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01324
Species: Human
Expression System: E. coli
ACE2/ACEH Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01838
Species: Mouse
Expression System: HEK293 Cells
NADP-ME Protein, Human, Recombinant (His)
Cat.No: TMPH-01743
Species: Human
Expression System: E. coli
ACE2/ACEH Protein, Rhesus, Recombinant (hFc)
Cat.No: TMPY-03561
Species: Rhesus
Expression System: HEK293 Cells
ACE2/ACEH Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-03830
Species: Rhesus
Expression System: HEK293 Cells
ACE2/ACEH Protein, Mouse, Recombinant (His & hFc)
Cat.No: TMPY-01839
Species: Mouse
Expression System: HEK293 Cells
BACE1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00678
Species: Mouse
Expression System: HEK293 Cells
SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc)
Cat.No: TMPH-03163
Species: Protobothrops flavoviridis
Expression System: E. coli
ACE2/ACEH Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-05725
Species: Human
Expression System: Baculovirus Insect Cells
ACE2/ACEH Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-06334
Species: Human
Expression System: HEK293 Cells
BACE1 Protein, Human, Recombinant
Cat.No: TMPY-00652
Species: Human
Expression System: HEK293 Cells
ACE2/ACEH Protein, Human, Recombinant (mFc)
Cat.No: TMPY-04312
Species: Human
Expression System: HEK293 Cells
ACE2/ACEH Protein, Human, Recombinant (His)
Cat.No: TMPY-05266
Species: Human
Expression System: HEK293 Cells
UBE2K Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPJ-01039
Species: Human
Expression System: E. coli
ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated
Cat.No: TMPJ-00386
Species: Human
Expression System: HEK293 Cells
SVTLE Protein, Calloselasma rhodostoma, Recombinant (His)
Cat.No: TMPH-00324
Species: Calloselasma rhodostoma
Expression System: P. pastoris (Yeast)
BACE1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00651
Species: Human
Expression System: HEK293 Cells
BACE1 Protein, Human, Recombinant (His)
Cat.No: TMPY-00752
Species: Human
Expression System: HEK293 Cells
UBE2D3 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-02288
Species: Human
Expression System: E. coli
SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc)
Cat.No: TMPH-00768
Species: Gloydius ussuriensis
Expression System: E. coli
UBE2F Protein, Human, Recombinant (His)
Cat.No: TMPY-02605
Species: Human
Expression System: E. coli
ACE2/ACEH Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-05696
Species: Human
Expression System: HEK293 Cells
ACE2/ACEH Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00655
Species: Human
Expression System: HEK293 Cells
UBC11 Protein, Arabidopsis thaliana, Recombinant (His)
Cat.No: TMPH-00108
Species: Arabidopsis thaliana
Expression System: E. coli
UBE2S Protein, Human, Recombinant (GST)
Cat.No: TMPJ-01138
Species: Human
Expression System: E. coli
ECE1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01929
Species: Human
Expression System: HEK293 Cells
UBE2J2 Protein, Human, Recombinant (GST)
Cat.No: TMPJ-01221
Species: Human
Expression System: E. coli
UBE2D4 Protein, Human, Recombinant (His)
Cat.No: TMPY-02604
Species: Human
Expression System: E. coli
SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc)
Cat.No: TMPH-00215
Species: Bothrops jararaca
Expression System: E. coli
UBE2D3 Protein, Human, Recombinant
Cat.No: TMPJ-00571
Species: Human
Expression System: E. coli
UBE2K Protein, Human, Recombinant (GST)
Cat.No: TMPJ-01038
Species: Human
Expression System: E. coli
Autolysin Protein, Chlamydomonas reinhardtii, Recombinant (His & SUMO)
Cat.No: TMPH-00395
Species: Chlamydomonas reinhardtii
Expression System: E. coli
UBE2M Protein, Human, Recombinant
Cat.No: TMPY-02609
Species: Human
Expression System: E. coli
UBC10 Protein, Arabidopsis thaliana, Recombinant (His)
Cat.No: TMPH-00107
Species: Arabidopsis thaliana
Expression System: E. coli
UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
Cat.No: TMPH-00109
Species: Arabidopsis thaliana
Expression System: E. coli
ECE2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01891
Species: Human
Expression System: HEK293 Cells
ECE2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00782
Species: Human
Expression System: HEK293 Cells
UBE2W Protein, Human, Recombinant (His)
Cat.No: TMPY-02642
Species: Human
Expression System: E. coli
UBE2H Protein, Human, Recombinant (GST)
Cat.No: TMPJ-01047
Species: Human
Expression System: E. coli
UBE2L6 Protein, Human, Recombinant (His)
Cat.No: TMPY-02842
Species: Human
Expression System: E. coli
UBE2G1 Protein, Human, Recombinant
Cat.No: TMPY-02606
Species: Human
Expression System: E. coli
SUMF1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01229
Species: Human
Expression System: HEK293 Cells
UBE2T Protein, Human, Recombinant (His)
Cat.No: TMPY-04263
Species: Human
Expression System: E. coli
UBC9/UBE2I Protein, Human, Recombinant
Cat.No: TMPY-02608
Species: Human
Expression System: E. coli
HADHB Protein, Human, Recombinant (GST)
Cat.No: TMPH-02245
Species: Human
Expression System: E. coli
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Cat. No. Product Name Target Signaling Pathways
TMIJ-0444 Coenzyme Q10-d6

Coenzyme Q10-d6 是 Coenzyme Q10 的氘代化合物。Coenzyme Q10 的 CAS 号为 303-98-0。Coenzyme Q10是来自藤仓赤霉菌的一种天然产物,在线粒体呼吸链中充当电子载体。
T11193 Enalaprilat-d5 sodium

MK-422 D5 Sodium Salt,依那普利拉钠 D5,Enalaprilat D5 Sodium Salt

Others Others
Enalaprilat D5 Sodium Salt is the deuterium labeled Enalaprilat, which is an angiotensin-converting enzyme (ACE) inhibitor.
T11192 Enalapril D5 maleate

MK-421 D5 maleate,马来酸依那普利D5

Others Others
Enalapril D5 maleate is deuterium labeled Enalapril, which is an angiotensin converting enzyme (ACE) inhibitor.
T11194 Enalaprilat D5

MK-422 D5,依那普利拉 D5

Others Others
Enalaprilat D5 is the deuterium labeled Enalaprilat, which is an angiotensin-converting enzyme (ACE) inhibitor.
T13196 Trandolaprilate D5

Trandolaprilat D5,RU 44403 D5

Others Others
Trandolaprilate D5 is a deuterium-labeled Trandolaprilate. Trandolaprilate is an inhibitor of angiotensin-converting enzyme (ACE).
T13195 Trandolapril D5

RU44570 D5

Others Others
Trandolapril D5 is a deuterium labeled Trandolapril. Trandolapril is an orally active inhibitor of angiotensin converting enzyme (ACE) for hypertension and congestive heart failure (CHF).
T10661 Calcifediol-D6

骨化二醇 D6

Others Others
Calcifediol-D6 is the deuterated form of Calcifediol, which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 by the enzyme cholecalciferol 25-hydroxylase.
TMIJ-0176 Perindopril-d4

Perindopril-d4 是 Perindopril 的氘代化合物。Perindopril 的 CAS 号为 95153-31-4。Perindoprilat 是一种血管紧张素转换酶抑制剂。
T70883 Moexipril-d5

Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) ...
TMIJ-0177 Perindoprilat-d4

Perindoprilat-d4 是 Perindoprilat 的氘代化合物。Perindoprilat 的 CAS 号为 95153-31-4。Perindoprilat 是一种血管紧张素转换酶抑制剂。
TMIH-0530 Sulbactam-d2

Sulbactam-d2 是 Sulbactam 的氘代化合物。Sulbactam 的 CAS 号为 68373-14-8。Sulbactam是一种竞争性、不可逆的 β-内酰胺酶抑制剂,抑制耐多药不动杆菌-鲍曼不动杆菌复合物。它具有抗菌活性。
T71065 Quinapril-d5

Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
TMIJ-0253 Benazepril-d5 HCl

Benazepril-d5 HCl 是 Benazepril HCl 的氘代化合物。Benazepril HCl 的 CAS 号为 86541-74-4。Benazepril hydrochloride 是一种血管紧张素转化酶(ACE)抑制剂,能够作用于高血压。
T36903 Rasagiline-13C3 (mesylate)

Rasagiline-13C3 (mesylate)

Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede...
T71205 Fosinopril-d7 sodium salt

Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti...
TMIH-0096 Apigenin-d6

Apigenin-d6 是 Apigenin 的氘代化合物。Apigenin 的 CAS 号为 520-36-5。Apigenin 是从韩信草中提取的一种天然产物,是一种竞争性CYP2C9抑制剂,Ki为 2 μM。它被用作镇静剂、温和的镇痛剂和安眠药。
TMIH-0095 Apigenin-d4

Apigenin-d4 是 Apigenin 的氘代化合物。Apigenin 的 CAS 号为 520-36-5。Apigenin 是从韩信草中提取的一种天然产物,是一种竞争性CYP2C9抑制剂,Ki为 2 μM。它被用作镇静剂、温和的镇痛剂和安眠药。
TMIJ-0274 Sulindac-d3

Sulindac-d3 是 Sulindac 的氘代化合物。Sulindac 的 CAS 号为 38194-50-2。Sulindac 是一种非甾体类抗炎剂,可抑制COX-2的活性,也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药,具有潜在的抗肿瘤活性。
TMIH-0512 Salbutamol-d3

Salbutamol-d3 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。
TMID-0233 Salbutamol-d9

Salbutamol-d9 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。
TMID-0078 Irinotecan-d10 Hydrochloride

Irinotecan-d10 Hydrochloride 是 Irinotecan Hydrochloride 的氘代化合物。Irinotecan Hydrochloride 的 CAS 号为 100286-90-6。Irinotecan Hydrochloride 是喜树碱半合成衍生物的盐酸盐,是一种拓扑异构酶 I 抑制剂,可研究结肠癌和直肠癌。
T70882 Orlistat-d3

Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit...
TMIJ-0114 Vardenafil-d5

Vardenafil-d5 是 Vardenafil 的氘代化合物。Vardenafil 的 CAS 号为 224785-90-4。Vardenafil 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂,IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解,从而提高 cGMP 水平。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。

同位素标记化合物

Coenzyme Q10-d6
Cat.No: TMIJ-0444
Synonym:
Target:
Enalaprilat-d5 sodium
Cat.No: T11193
Synonym: MK-422 D5 Sodium Salt,依那普利拉钠 D5,Enalaprilat D5 Sodium Salt
Target: Others
Enalapril D5 maleate
Cat.No: T11192
Synonym: MK-421 D5 maleate,马来酸依那普利D5
Target: Others
Enalaprilat D5
Cat.No: T11194
Synonym: MK-422 D5,依那普利拉 D5
Target: Others
Trandolaprilate D5
Cat.No: T13196
Synonym: Trandolaprilat D5,RU 44403 D5
Target: Others
Trandolapril D5
Cat.No: T13195
Synonym: RU44570 D5
Target: Others
Calcifediol-D6
Cat.No: T10661
Synonym: 骨化二醇 D6
Target: Others
Perindopril-d4
Cat.No: TMIJ-0176
Synonym:
Target:
Moexipril-d5
Cat.No: T70883
Synonym:
Target:
Perindoprilat-d4
Cat.No: TMIJ-0177
Synonym:
Target:
Sulbactam-d2
Cat.No: TMIH-0530
Synonym:
Target:
Quinapril-d5
Cat.No: T71065
Synonym:
Target:
Benazepril-d5 HCl
Cat.No: TMIJ-0253
Synonym:
Target:
Rasagiline-13C3 (mesylate)
Cat.No: T36903
Synonym: Rasagiline-13C3 (mesylate)
Target:
Fosinopril-d7 sodium salt
Cat.No: T71205
Synonym:
Target:
Apigenin-d6
Cat.No: TMIH-0096
Synonym:
Target:
Apigenin-d4
Cat.No: TMIH-0095
Synonym:
Target:
Sulindac-d3
Cat.No: TMIJ-0274
Synonym:
Target:
Salbutamol-d3
Cat.No: TMIH-0512
Synonym:
Target:
Salbutamol-d9
Cat.No: TMID-0233
Synonym:
Target:
Irinotecan-d10 Hydrochloride
Cat.No: TMID-0078
Synonym:
Target:
Orlistat-d3
Cat.No: T70882
Synonym:
Target:
Vardenafil-d5
Cat.No: TMIJ-0114
Synonym:
Target:
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