Transglutaminase (TG) is a thiolase that induces intermolecular cross-linking of proteins, by catalysing the formation of isopeptide bonds between the γ-carboxamide group of glutamine residues and the primary ε-amine group of other compounds. The enzyme plays a role in a variety of physiological processes including coagulation, antimicrobial immune responses and photosynthesis.

Transglutaminase的活性可通过Co 2+、Ba 2+ 和 K+ 增强[1]。而微生物源Transglutaminase受到Zn 2+、Cu 2+、Hg 2+ 以及Pb 2+ 离子的抑制，这些离子与活性中心的半胱氨酸的硫醇基团结合[1]。