Lipoprotein lipase (LPL) is an enzyme, mainly involved in lipid metabolism, that hydrolyzes triglycerides in lipoproteins.LPL can be a target for obesity/diabetes-related cardiovascular diseases and has an important role in lowering triglyceride levels and improving cardiovascular.

采用小鼠/人类巨噬细胞系（如RAW264.7、THP-1），通过添加脂蛋白脂肪酶（Lipoprotein lipase）并结合流式细胞术、免疫荧光及荧光标记脂质检测，结果显示，脂蛋白脂肪酶显著诱导巨噬细胞向M2型（抗炎型）极化。M2型标志物（如CD206、CD163）在脂蛋白脂肪酶处理的巨噬细胞中高表达，同时，这些细胞对荧光标记脂质的摄取能力也显著增强[1]。