WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1. Moreover, WRR139 amplifies the cytotoxic effects of Carfilzomib on cancer cells [1].

WRR139（0.01-100 μM；1小时）能够抑制体外NGLY1并干扰HEK293细胞Nrf1的加工[1]。同一化合物以5 μM浓度作用18小时，可干扰HEK293细胞内Nrf1的加工、定位及激活[1]。此外，WRR139在1 μM浓度下，经过24小时处理，能NGLY1依赖性地提高Carfilzomib对U266、H929和Jurkat细胞的细胞毒性[1]。