OGT 2115

Name: OGT 2115
Brand: TargetMol
SKU: T16380
Price: 283 USD
Availability: InStock
Rating: 5 (10 reviews)

很棒

产品编号 T16380Cas号 853929-59-6

OGT 2115是一种肝素酶(IC50 = 0.4µM)抑制剂，肝素酶是一种将硫酸肝素分解成葡萄糖醛酸(GlcUA)和 n -乙酰氨基葡萄糖(GlcNAc)的酶。同时，OGT 2115也具有抗血管生成性能(IC50=1 μM)。

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很棒

纯度: 97.21%

产品编号 T16380Cas号 853929-59-6

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"OGT 2115"的相关化合物库

Bioactive Compound Library

L400017100 化合物

Covalent Inhibitor Library

L94102400 化合物

Bioactive Compounds Library Max

L401025682 化合物

Inhibitor Library

L20009730 化合物

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纯度:97.21%

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生物活性

产品描述	OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 µM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). OGT 2115 also showed antiangiogenic properties (IC50=1 μM).
靶点活性	Heparanase:0.4 μM
体外活性	OGT 2115 obviously inhibits the invasion and migration induced by Adriamycin. Furthermore, the MTT assay results display that OGT 2115 does not decrease the anti-proliferative effect of Adriamycin. Heparanase InhibitorOGT 2115 can inhibit metastasis induced by endoplasmic reticulum (ER) stress in breast cancer cells, although not significantly. The number and rate of migrated cells are significantly reduced following the exposure of the cells to Tunicamycin + OGT 2115, compared with the control group [2].
体内活性	OGT 2115 displays a plasma concentration of ~10x the heparanase IC50 following oral dosing at 20 mg/kg when administered to mice[1].

化学信息

分子量	495.3
分子式	C₂₄H₁₆BrFN₂O₄
CAS No.	853929-59-6
Smiles	OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2ccc(Br)cc2)c(F)c1
密度	1.574 g/cm3 (Predicted)