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Fomepizole (4-Methylpyrazole) 是细胞色素 P450 (CYP2E1) 抑制剂。它是乙醇脱氢酶 (alcohol dehydrogenase) 竞争性抑制剂。它能够阻断甲醇和乙二醇进一步转化为有毒代谢产物。它具有成为乙二醇或甲醇中毒的解毒剂的潜力。
Fomepizole (4-Methylpyrazole) 是细胞色素 P450 (CYP2E1) 抑制剂。它是乙醇脱氢酶 (alcohol dehydrogenase) 竞争性抑制剂。它能够阻断甲醇和乙二醇进一步转化为有毒代谢产物。它具有成为乙二醇或甲醇中毒的解毒剂的潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 mg | ¥ 350 | 现货 | |
1 g | ¥ 494 | 现货 | |
5 g | ¥ 1,580 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 418 | 现货 |
产品描述 | Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. |
别名 | 甲吡唑, Antizol-Vet, Antizol, 4-甲基吡唑, 4-Methylpyrazole |
分子量 | 82.1 |
分子式 | C4H6N2 |
CAS No. | 7554-65-6 |
Smiles | CC1=CNN=C1 |
密度 | 1.015 g/cm3. Temperature:20 °C. |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 100 mg/mL (1218.03 mM), Sonication is recommended. DMSO: 60 mg/mL (730.82 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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