规格

价格

库存

数量

2 mg

¥ 740

现货

5 mg

¥ 1,230

5日内发货

25 mg

¥ 4,480

6-8周

50 mg

¥ 5,820

6-8周

100 mg

¥ 8,730

6-8周

1 mL x 10 mM (in DMSO)

¥ 1,370

5日内发货

生物活性

产品描述	GSK180 is a selective, competitive, and highly potent inhibitor of kynurenine-3-monooxygenase (KMO), a critical enzyme in the tryptophan metabolic pathway, with an IC50 value of approximately 6 nM, displaying minimal off-target activity against other tryptophan pathway enzymes, rapidly altering kynurenine metabolite profiles, GSK180 serves as a powerful research tool for probing the biological and therapeutic implications of KMO inhibition in metabolic, neurological, and inflammatory disease models.
靶点活性	KMO:6 nM
体外活性	GSK180 inhibits endogenous KMO activity in primary human hepatocytes (IC50=2.6 μM) and it also inhibits rat KMO slightly less potently than the human enzyme (IC50=7 μM).
体内活性	GSK180 is fit for i.v. management [1].
别名	GSK-180, GSK180, GSK 180

化学信息

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 200 mg/mL (724.45 mM), Sonication is recommended.

溶液配制表

DMSO