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DEC-RVRK-CMK TFA为一种肽类CMK(氯甲基酮)抑制剂,它专门针对并使分泌性可溶性蛋白酶kexin(Kex2,Ki=8.45 μM)失活.kexin(EC 3.4.21.61),一种酵母酶,是蛋白酶K家族内的一员,为钙依赖性跨膜丝氨酸蛋白酶.Kex2与不同CMK抑制剂之间的相互作用机制主要依赖于其对亚基的选择性,尤其是在P1位点上赖氨酸与精氨酸的选择性不同,这影响了其结合强度.
DEC-RVRK-CMK TFA为一种肽类CMK(氯甲基酮)抑制剂,它专门针对并使分泌性可溶性蛋白酶kexin(Kex2,Ki=8.45 μM)失活.kexin(EC 3.4.21.61),一种酵母酶,是蛋白酶K家族内的一员,为钙依赖性跨膜丝氨酸蛋白酶.Kex2与不同CMK抑制剂之间的相互作用机制主要依赖于其对亚基的选择性,尤其是在P1位点上赖氨酸与精氨酸的选择性不同,这影响了其结合强度.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) with a Ki value of 8.45 μM. Kex2, a yeast enzyme and a member of the mammalian subtilisin-like proprotein convertase family within the serine protease class, is a calcium-dependent transmembrane protease. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly noting the differences in selectivity between lysine and arginine at the P1 position, which influences their varying binding affinities. |
别名 | Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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