TNF Protease Inhibitor 2

Name: TNF Protease Inhibitor 2
Brand: TargetMol
SKU: TQ0129
Price: 346 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 TQ0129Cas号 187034-31-7

别名 TAPI-2

TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).

TNF Protease Inhibitor 2

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产品编号 TQ0129 别名 TAPI-2Cas号 187034-31-7

TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).

规格	价格	库存
5 mg	询价	期货
50 mg	询价	期货
100 mg	询价	期货

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产品介绍

生物活性

产品描述	TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).
靶点活性	MMP:1.5 nM (Ki), MMP:20 μM
体外活性	TAPI-2 bounds to h-meprin with IC50 20 μM for h-meprin β subunit and 1.5 nM for h-meprin α subunit. Generally, h-meprin α is inhibited more strongly than the β subunit [1]. Without affecting ADAM17 expression, TAPI-2 dramatically decreases the protein levels of NICD and its downstream target HES-1 in both HCP-1 and HT29 cells. Moreover, treating cells with TAPI-2 significantly decreases the CSC phenotype by -50% in both CRC cell lines. The dose-dependent effects of TAPI-2 on the sphere formation and protein levels of NICD and HES-1 confirm that the concentration used (20 μM) is within the effective dose range of TAPI-2 (5–40 μM) [2].
别名	TAPI-2

化学信息

分子量	415.53
分子式	C₁₉H₃₇N₅O₅
CAS No.	187034-31-7

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 20 mg/mL (48.13 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4066 mL	12.0328 mL	24.0657 mL	120.3283 mL
5 mM	0.4813 mL	2.4066 mL	4.8131 mL	24.0657 mL
10 mM	0.2407 mL	1.2033 mL	2.4066 mL	12.0328 mL
20 mM	0.1203 mL	0.6016 mL	1.2033 mL	6.0164 mL