Loxosceles Spiniceps Venom, derived from Loxosceles Spiniceps, is a complex venom composed of proteins, glycoproteins, and low molecular mass peptides. This venom contains various protein classes such as astacin-like metalloprotease, insecticidal peptides of low molecular mass, inhibitor cysine knot peptides (ICK), and phospholipase-D. The presence of the enzyme sphingomyelinase D in the venom is responsible for inducing necrosis [1].