Loxosceles Bergeri venom, derived from Loxosceles Bergeri, comprises a sophisticated blend of toxins featuring proteins, glycoproteins, and low molecular mass peptides. Identified protein classes within this venom include astacin-like metalloprotease, insecticidal peptides of low molecular mass, inhibitor cystine knot peptides (ICK), and phospholipase-D, with the enzyme sphingomyelinase D playing a pivotal role in necrosis development [1].