MF63

Name: MF63
Brand: TargetMol
SKU: T16070
Price: 378 CNY
Availability: InStock
Rating: 5 (10 reviews)

很棒

产品编号 T16070Cas号 892549-43-8

MF63 is a selective mPGES-1 inhibitor (IC50: 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively).

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MF63

很棒

产品编号 T16070Cas号 892549-43-8

MF63 is a selective mPGES-1 inhibitor (IC50: 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively).

规格	价格	库存
1 mg	¥ 378	现货
5 mg	¥ 892	现货
10 mg	¥ 1,490	现货
25 mg	¥ 2,520	现货
50 mg	¥ 3,690	现货
100 mg	¥ 5,290	现货
200 mg	¥ 7,230	现货
1 mL x 10 mM (in DMSO)	¥ 981	现货

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产品介绍

生物活性

产品描述

MF63 is a selective mPGES-1 inhibitor (IC50: 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively).

体外活性

MF63 strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme, in rodent species. mPGES-1 MF63 potently inhibited the human mPGES-1 enzyme with a high degree (>1000-fold) of selectivity over other prostanoid synthases. The compound selectively inhibited the synthesis of PGE(2) when tested in the guinea pig and a knock-in (KI) mouse expressing human mPGES-1, but not other prostaglandins inhibitable by nonsteroidal anti-inflammatory drugs (NSAIDs), yet retained NSAID-like efficacy at inhibiting lipopolysaccharide-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain.

化学信息

分子量	378.81
分子式	C₂₃H₁₁ClN₄
CAS No.	892549-43-8
Smiles	Clc1ccc2c3[nH]c(nc3c3ccccc3c2c1)-c1c(cccc1C#N)C#N
密度	1.49 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 43 mg/mL (113.51 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6398 mL	13.1992 mL	26.3985 mL	131.9923 mL
5 mM	0.5280 mL	2.6398 mL	5.2797 mL	26.3985 mL
10 mM	0.2640 mL	1.3199 mL	2.6398 mL	13.1992 mL
20 mM	0.1320 mL	0.6600 mL	1.3199 mL	6.5996 mL
50 mM	0.0528 mL	0.2640 mL	0.5280 mL	2.6398 mL
100 mM	0.0264 mL	0.1320 mL	0.2640 mL	1.3199 mL