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Pralnacasan
还可以产品编号 T16570Cas号 192755-52-5
别名 VX-740, HMR 3480
Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment.
Pralnacasan
还可以产品编号 T16570 别名 VX-740, HMR 3480Cas号 192755-52-5
Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 6,520 | 期货 |
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生物活性
化学信息
| 产品描述 | Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment. |
| 靶点活性 | IL-1β converting enzyme:1.4 nM （ki） |
| 体内活性 | Pralnacasan treatment does not appear to affect the weight of the animals. Pralnacasan (0 -50 mg/kg; oral gavage; twice a day; for 6 weeks; female Balb/c mice) treatment decreases joint damage [1]. |
| 别名 | VX-740, HMR 3480 |
| 分子量 | 523.54 |
| 分子式 | C26H29N5O7 |
| CAS No. | 192755-52-5 |
| 密度 | 1.44 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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