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TMPY-02127
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DUSP3 Protein, Human, Recombinant (His & GST)
VHR,dual specificity phosphatase 3
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Human
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Baculovirus Insect Cells
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DUSP3 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 48.3 kDa and the accession number is P51452. |
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TMPY-03482
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DUSP3 Protein, Human, Recombinant
dual specificity phosphatase 3,VHR
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Human
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Baculovirus Insect Cells
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DUSP3 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 20.6 kDa and the accession number is P51452. |
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TMPY-02595
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DUSP14 Protein, Human, Recombinant (His & MBP)
MKP6,MKP-L,dual specificity phosphatase 14
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Human
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E. coli
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Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (... |
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TMPJ-00996
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VHR Protein, Human, Recombinant (His)
DUSP3,VHR,Dual specificity protein phosphatase VHR,...
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Human
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E. coli
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Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively ... |
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TMPY-04380
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DYRK3 Protein, Human, Recombinant (His & GST)
REDK,RED,DYRK5,dual-specificity tyrosine-(Y)-phosph...
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Human
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Baculovirus Insect Cells
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Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains oneprotein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hemat... |
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TMPH-01703
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CDC25C Protein, Human, Recombinant (His)
Dual specificity phosphatase Cdc25C,M-phase inducer...
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Human
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E. coli
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Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. CDC25C Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.4 kDa and the accession number is P30307. |
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TMPH-03254
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PDE1C Protein, Rat, Recombinant (His)
Dual specificity calcium/calmodulin-dependent 3',5'...
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Rat
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E. coli
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PDE1C Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 92.6 kDa and the accession number is Q63421. |
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TMPH-01251
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DUSP26 Protein, Human, Recombinant (His & SUMO)
MKP-8,NATA1,DSP-4,SKRP3,DUSP26,MKP8,LDP-4,LDP4,DUSP24,Du...
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Human
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E. coli
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Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). |
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TMPH-01250
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MAP2K3 Protein, Human, Recombinant (His & SUMO)
MAP2K3,MAPK/ERK kinase 3,Dual specificity mitogen-a...
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Human
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E. coli
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Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. MAP2K3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.3 kDa and the accession numbe... |
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TMPY-04544
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MEK2 Protein, Human, Recombinant (GST)
mitogen-activated protein kinase kinase 2,FLJ26075,MKK2,CFC4...
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Human
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Baculovirus Insect Cells
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Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ... |
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TMPY-04572
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MKK4 Protein, Mouse, Recombinant (His & GST)
MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated protein ...
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Mouse
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Baculovirus Insect Cells
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Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ... |
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TMPY-04552
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AKT1 Protein, Human, Recombinant (His)
RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,...
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Human
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Baculovirus Insect Cells
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v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac... |
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TMPH-02271
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BTK Protein, Human, Recombinant (His)
BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine-protein kina...
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Human
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Baculovirus Insect Cells
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Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in... |
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TMPK-00798
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IGSF11 Protein, Mouse, Recombinant (His)
Bt-IGSF,BtIGSF,IgSF11,VSIG3,Bt IGSF,CXADRL1,CT119
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Mouse
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HEK293 Cells
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Immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially expressed in the brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors (AMPARs). |
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TMPK-00634
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MSPR/Ron Protein, Human, Recombinant (His)
MST1R,RON,MSP R,CD136,PTK8,p185-Ron,MSPR,CDw136,MSP receptor
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Human
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HEK293 Cells
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Macrophage-stimulating protein (MSP) is a serum protein belonging to the plasminogen-related growth factor family. The specific receptor for MSP is the RON (recepteur d'origine nantais) receptor tyrosine kinase - a member of the MET proto-oncogene family. Activation of RON by MSP exerts dual functions on macrophages. |
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TMPY-04546
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CLK3 Protein, Human, Recombinant (GST)
PHCLK3,CDC-like kinase 3,PHCLK3/152
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Human
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Baculovirus Insect Cells
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Dual specificity protein kinase CLK3, also known as CDC-like kinase 3, and CLK3, is a member of CMGC Ser/Thr protein kinase family and Lammer subfamily. Mammalian CLK is the prototype for a family of dual specificity kinases (termed Lammer kinases) that have been conserved in evolution. CLK family members have shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR prote... |
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TMPK-00806
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GHR/Growth Hormone R Protein, Human, Recombinant (His)
GHR/BP,GH receptor,GHBP,GHR
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Human
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HEK293 Cells
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Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual functions based on its localization in the plasma membrane and nucleus. |
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TMPH-00433
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Ex-FABP Protein, Coturnix coturnix japonica, Recombinant (His & Myc)
Extracellular fatty acid-binding protein,Lipocalin Q83
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Coturnix coturnix japonica
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E. coli
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Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor. Ex-FABP Protein, Coturnix coturnix japonica, Recombinant (His & Myc) is expr... |
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TMPY-03672
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Survivin Protein, Human, Recombinant
BIRC5,IAP4,API4,baculoviral IAP repeat containing 5,EPR-1
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Human
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E. coli
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BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation... |
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TMPY-05095
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RAF1 Protein, Human, Recombinant (His & GST)
Raf-1 proto-oncogene, serine/threonine kinase,CRAF,NS5,CMD1N...
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Human
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Baculovirus Insect Cells
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RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell p... |
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TMPY-02977
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PDE1C Protein, Human, Recombinant (His & GST)
hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-...
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Human
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Baculovirus Insect Cells
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PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s... |
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TMPY-02704
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PTMA Protein, Human, Recombinant (GST)
prothymosin, α,prothymosin, alpha,TMSA
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Human
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E. coli
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PTMA (prothymosin, alpha, N-GST chimera) is a small, 12.4 kDa protein. It is a 109-111 amino acid long polypeptide as the precursor of thymosin a1. Thymosins are named becaues they were originally isolated from the thymus. But now in many other tissues, thymosins also can be detected. Thymosins have diverse biological activities, and two in particular, thymosins a1 and _4, have potentially important uses in medicine, some of which have already progressed from the laboratory to the clinic. In gen... |
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TMPY-01819
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PDE1B Protein, Human, Recombinant (His & GST)
PDES1B,phosphodiesterase 1B, calmodulin-dependent,PDE1B1
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Human
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Baculovirus Insect Cells
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Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-1A (PDE1A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It b... |
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TMPY-02081
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PDE2A Protein, Human, Recombinant (aa 215-900, His)
phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4,PDE2A1,C...
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Human
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Baculovirus Insect Cells
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cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ... |
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TMPY-02010
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DMP1 Protein, Human, Recombinant (His)
ARHR,dentin matrix acidic phosphoprotein 1,ARHP,DMP-1
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Human
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HEK293 Cells
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Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. DMP1 contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nu... |
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TMPY-04547
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PBK/TOPK Protein, Human, Recombinant (His)
HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK
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Human
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Baculovirus Insect Cells
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PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun... |
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TMPY-02519
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BLVRB Protein, Human, Recombinant (His)
HEL-S-10,biliverdin reductase B,FLR,BVRB,SDR43U1
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Human
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E. coli
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Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i... |
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TMPY-02213
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RAIDD Protein, Human, Recombinant (His)
RAIDD,MRT34,CASP2 and RIPK1 domain containing adaptor with d...
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Human
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E. coli
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Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the ... |
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